利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

584 条记录 (耗时 0.023 秒)

    .beta.-Lactams
    81.
    发明授权
    .beta.-Lactams 失效
    β-内酰胺

    公开(公告)号：US4576751A

    公开(公告)日：1986-03-18

    申请号：US407027

    申请日：1982-08-11

    申请人： Christian N. Hubschwerlen ,  Gerard Schmid

    发明人： Christian N. Hubschwerlen ,  Gerard Schmid

    IPC分类号： C07D205/08 ,  C07D205/085 ,  C07D277/40 ,  C07D317/28 ,  C07D317/36 ,  C07D317/72 ,  C07D319/12 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D493/14

    CPC分类号： C07D317/72 ,  C07D205/085 ,  C07D277/40 ,  C07D317/28 ,  C07D403/04 ,  C07D405/14 ,  C07D493/14 ,  Y02P20/55

    摘要： There is presented optically uniform .beta.-lactams of the formulae ##STR1## wherein Z is a readily cleavable acyl group, R.sup.1 is amino or a group convertible into amino, R.sup.2 is hydrogen or a readily cleavable protecting group and R.sup.3 and R.sup.4 each are a lower hydrocarbon group which optionally contains oxygen and which is attached via a carbon atom, whereby these groups can also be joined with one another to form a ring, with the proviso that R.sup.1 is a readily cleavable acylamino when R.sup.2 is hydrogen,and the corresponding optical antipodes, their manufacture and use in the manufacture of antimicrobially-active .beta.-lactams as well as novel intermediates usable in their manufacture.

    摘要翻译： 呈现光学上均匀的β-内酰胺，其中Z是易裂解的酰基，R 1是氨基或可转化成氨基的基团，R 2是氢或易裂解的保护基，并且R 3和R 4各自是低级 烃基，其任选地含有氧并且经由碳原子连接，由此这些基团也可以彼此连接形成环，条件是当R 2是氢时，R 1是易裂解的酰氨基，并且相应的光学对映体 ，其制造和用于制造抗微生物活性β-内酰胺以及可用于其制造的新型中间体。

    2-Amino-4-(4-benzyloxyphenyl)thiazoles, and their use in hyperlipemia
    86.
    发明授权
    2-Amino-4-(4-benzyloxyphenyl)thiazoles, and their use in hyperlipemia 失效
    2-氨基-4-（4-苄氧基苯基）噻唑，以及它们在高脂血症中的应用

    公开(公告)号：US4348403A

    公开(公告)日：1982-09-07

    申请号：US197755

    申请日：1980-10-16

    申请人： Yutaka Kawamatsu ,  Takashi Sohda ,  Yoshio Imai

    发明人： Yutaka Kawamatsu ,  Takashi Sohda ,  Yoshio Imai

    IPC分类号： C07D277/20 ,  A61K31/425 ,  A61K31/426 ,  A61P3/06 ,  C07D277/38 ,  C07D277/40 ,  C07D277/42 ,  C07D277/46

    CPC分类号： C07D277/46 ,  C07D277/40 ,  C07D277/42

    摘要： 2-Amino-4-(4-benzyloxyphenyl)thiazole compounds of the formula: ##STR1## wherein X is hydrogen, a halogen, a lower alkyl having 1 to 4 carbon atoms or trifluoromethyl; R is hydrogen, a lower alkyl having 1 to 4 carbon atoms, a lower alkenyl having 2 to 4 carbon atoms or a carboxylic acyl having 1 to 6 carbon atoms; and n is 1 or 2, or pharmaceutically acceptable salts thereof, are novel compounds and are useful as a prophylactic agent or therapeutic agent against hyperlipemia in mammals including human beings.

    摘要翻译： 下式的2-氨基-4-（4-苄氧基苯基）噻唑化合物：其中X是氢，卤素，具有1至4个碳原子的低级烷基或三氟甲基; R是氢，具有1至4个碳原子的低级烷基，具有2至4个碳原子的低级链烯基或具有1至6个碳原子的羧基酰基; 并且n为1或2或其药学上可接受的盐是新化合物，并且可用作预防剂或治疗剂，用于包括人在内的哺乳动物中的高脂血症。

    Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides
    87.
    发明授权
    Antiulcer thiazol-2-ylcarbamoyl-carboxylic acids, esters and amides 失效
    抗溃疡噻唑-2-基氨基甲酰基 - 羧酸，酯和酰胺

    公开(公告)号：US4321372A

    公开(公告)日：1982-03-23

    申请号：US160046

    申请日：1980-06-16

    申请人： Saul B. Kadin

    发明人： Saul B. Kadin

    IPC分类号： C07D277/40 ,  C07D277/46 ,  C07D277/60 ,  C07D277/82 ,  C07D277/20

    CPC分类号： C07D277/60 ,  C07D277/40 ,  C07D277/46 ,  C07D277/82 ,  Y10S514/925

    摘要： This invention encompasses orally effective antiulcer agents of the formula ##STR1## wherein X is hydroxy, (C.sub.1 -C.sub.5)-alkoxy, phenoxy, benzyloxy, or --NH(CH.sub.2).sub.n Y wherein n is an integer of value 2 to 4 and Y is di-(C.sub.1 -C.sub.3)-alkylamino, 1-pyrrolidinyl, 1-piperidinyl or 4-morpholinyl;R' and R" when taken together are (C.sub.3 -C.sub.8)-alkylene, with the proviso that the ring so formed is 5- to 8-membered;R' and R" when taken separately are each independently hydrogen, (C.sub.1 -C.sub.6)-alkyl or (C.sub.5 -C.sub.6)-cycloalkyl, with the proviso that when X is other than --NH(CH.sub.2).sub.n Y, at least one of R' and R" is other than hydrogen;the pharmaceutically acceptable cationic salts thereof when X is hydroxyl, and the pharmaceutically acceptable anionic salts thereof when X is --NH(CH.sub.2).sub.n Y.

    摘要翻译： 本发明包括具有下式的口服有效的抗溃疡剂，其中X是羟基，（C1-C5） - 烷氧基，苯氧基，苄氧基或-NH（CH2）nY，其中n是2到4的整数，Y是 二 - （C 1 -C 3） - 烷基氨基，1-吡咯烷基，1-哌啶基或4-吗啉基; 当R'和R“合在一起时为（C 3 -C 8） - 亚烷基，条件是如此形成的环为5至8元; R'和R“分别独立地为氢，（C 1 -C 6） - 烷基或（C 5 -C 6） - 环烷基，条件是当X不是-NH（CH 2）n Y时， R'和R“不是氢; 当X为羟基时，其药学上可接受的阳离子盐及其药学上可接受的阴离子盐，当X为-NH（CH 2）n Y时。

    2-Acylaminothiazol-4-ylacetamides as post emergent selective herbicides
    89.
    发明授权
    2-Acylaminothiazol-4-ylacetamides as post emergent selective herbicides 失效
    2-酰基氨基噻唑-4-基乙酰胺作为出苗后选择性除草剂

    公开(公告)号：US4243407A

    公开(公告)日：1981-01-06

    申请号：US69026

    申请日：1979-08-23

    申请人： Roger P. Cahoy

    发明人： Roger P. Cahoy

    IPC分类号： A01N43/78 ,  A01N47/36 ,  A01N53/00 ,  C07D277/40 ,  C07D277/46 ,  C07D277/48

    CPC分类号： C07D277/48 ,  A01N43/78 ,  A01N47/36 ,  A01N53/00 ,  C07D277/40 ,  C07D277/46

    摘要： A class of amides disclosed to be useful as selective pre-emergent and post-emergent herbicides are those having the general structural formula ##STR1## in which R.sup.1 is hydrogen or methyl, R.sup.2 is ethyl, isopropyl, cyclopropyl, tert.butyl, methylamino, dimethylamino, ethylamino or methoxymethylamino, R.sup.3 is phenyl, 4-chlorophenyl, 3,4-dichlorophenyl, 4-methylphenyl or 4-methoxyphenyl, R.sup.4 is hydrogen or C.sub.1 to C.sub.3 lower alkyl, and R.sup.5 is hydrogen or methyl, with the further stipulation that either, but not both R.sup.4 and R.sup.5 may be hydrogen.

    摘要翻译： 一类被公开用作选择性出苗前和芽后除草剂的酰胺是具有通式结构式“IMAGE”的酰胺，其中R 1是氢或甲基，R 2是乙基，异丙基，环丙基，叔丁基，甲基氨基， 二甲基氨基，乙基氨基或甲氧基甲基氨基，R3是苯基，4-氯苯基，3,4-二氯苯基，4-甲基苯基或4-甲氧基苯基，R4是氢或C1-C3低级烷基，R5是氢或甲基，进一步规定 也可以是R4和R5都不是氢。

    Dichloroacetylimino herbicide antagonists as plant protection agents
    90.
    发明授权
    Dichloroacetylimino herbicide antagonists as plant protection agents 失效
    二氯乙酰亚氨基除草剂拮抗剂作为植物保护剂

    公开(公告)号：US4237302A

    公开(公告)日：1980-12-02

    申请号：US946975

    申请日：1978-09-29

    申请人： Otto L. Hoffman ,  Joel L. Kirkpatrick

    发明人： Otto L. Hoffman ,  Joel L. Kirkpatrick

    IPC分类号： A01N25/32 ,  A01N43/824 ,  C07D277/40 ,  C07D277/46 ,  C07D277/82 ,  C07D285/12 ,  C07D285/135 ,  A01N43/82 ,  C07D277/42

    CPC分类号： C07D285/135 ,  A01N25/32 ,  C07D277/40 ,  C07D277/46 ,  C07D277/82

    摘要： New compounds which are herbicide antagonists that are useful for protection of plants from various herbicides are members of the group having the general structural formulas: ##STR1## in which R is hydrogen or C.sub.1 to C.sub.4 alkyl, alkenyl or alkynyl, branched or straight chain, R.sup.1 is C.sub.1 to C.sub.3 alkyl, alkenyl or alkynyl, branched or straight chain, with the total number of carbon atoms in R and R.sup.1 being less than six, preferably less than four, on compounds with both R and R.sup.1 substituents. The novel plant protection agents may be applied both to seeds and to the soil.

    摘要翻译： 可用于保护来自各种除草剂的植物的除草剂拮抗剂的新化合物是具有以下结构式的基团的成员：其中R是氢或C1-C4烷基，烯基或炔基的一般结构式 ，支链或直链，R 1为C 1至C 3烷基，链烯基或炔基，支链或直链，其中R和R 1中的碳原子总数小于6，优选小于4，具有R和R 1的化合物 取代基。 新型植物保护剂可以应用于种子和土壤。