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公开(公告)号：US11060914B2
公开(公告)日：2021-07-13
申请号：US16147826
申请日：2018-09-30
IPC分类号： G01J3/42 , G01J3/02 , G01J3/06 , G01N21/552 , G01J3/28
摘要： An ATR scanner and method for calibrating the same are disclosed. The scanner includes an ATR objective having a reflecting face and an optical port adapted to receive a first light beam, and to focus the first light beam to a point, at a location on the reflecting face such that the first light beam is reflected by the reflecting face and no portion of the first light beam strikes the reflecting face at an angle greater than the critical angle. A detector measures an intensity of light reflected from the reflecting face. A controller controls the location of the focal point and determines an intensity of light that was incident on the reflecting face as a function of the position on the reflecting face and an intensity of light that was reflected from the reflecting face as a function of position on the reflecting face.
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公开(公告)号：US20030108181A1
公开(公告)日：2003-06-12
申请号：US10266878
申请日：2002-10-08
IPC分类号： H04M007/00
CPC分类号： H04Q3/0087
摘要： In a communications network, it is necessary for client software applications to monitor detail records constructed from messages transmitted in a signalling network (100) associated with the communications network. Prior techniques for delivery of the detail records to the client software applications included separate generation of the detail records for each client software application resulting in duplication of effort in the collection and dissemination of the detail records as well as the prolific number of detail record generation tasks required. The present invention overcomes these disadvantages by having a single generator (200, 410) of detail records per site in the signalling network (100), the delivery of the detail records to the client software applications (400, 402, 710, 712, 718) involving a point-to-multipoint communication.
摘要翻译： 在通信网络中，客户软件应用程序需要监视由与通信网络相关联的信令网络（100）中发送的消息构建的详细记录。 将详细记录传送到客户端软件应用程序的先前技术包括为每个客户端软件应用程序单独生成详细记录，导致在收集和传播详细记录以及多个细节记录生成任务的重复工作 需要。 本发明通过在信令网络（100）中具有每个站点的详细记录单个发生器（200,410）来克服这些缺点，将详细记录传送到客户端软件应用程序（400,402,710,712,718） ）涉及点对多点通信。
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公开(公告)号：US20230122968A1
公开(公告)日：2023-04-20
申请号：US17986361
申请日：2022-11-14
发明人： Douglas J. DELLINGER , Joel MYERSON , Brian SMART
IPC分类号： C07D405/12 , C07D317/34 , C07D403/06 , C07H21/02
摘要： Compounds and methods for purifying oligonucleotides such as RNA and DNA. A target oligonucleotide is reacted with an orthoester linker comprising an affinity tag to form an orthoester oligonucleotide-orthoester linker conjugate which is subjected to a purification technique to separate the target oligonucleotide from impurities such as truncated oligonucleotides. The orthoester linker can he then removed under mild conditions to generate the target oligonucleotide in high purity.
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4.发明申请公开(公告)号：US20230100871A1
公开(公告)日：2023-03-30
申请号：US17953246
申请日：2022-09-26
摘要： A flow cell, for detecting a fluidic sample separated by a sample separation apparatus, includes a cuvette, a flow channel formed at least partially in the cuvette and configured to enable a flow of the separated fluidic sample through the flow channel, an electromagnetic radiation inlet at which an excitation electromagnetic radiation beam is couplable into the cuvette, and an electromagnetic radiation outlet at which an emission electromagnetic radiation beam, generated by an interaction between the excitation electromagnetic radiation beam and the separated fluidic sample, is couplable out of the cuvette. A geometry of the cuvette is configured so that at least one point at the excitation backside surface of the cuvette is outside of a direct field of view of the electromagnetic radiation outlet.
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公开(公告)号：US11579459B2
公开(公告)日：2023-02-14
申请号：US16768506
申请日：2018-05-02
发明人： Sean M. Kent , Lindsay Buck
IPC分类号： G01J3/12 , G02B27/42 , G01J3/02 , G01J3/18 , G01J3/26 , G02B17/06 , G02B27/00 , G02B27/10 , G02B27/30
摘要： A polychromator system comprising: an optical element defining an aperture; a collimation mirror for receiving light via the aperture and reflecting substantially collimated light; at least a first dispersive optical component and a second dispersive optical component, each configured to disperse the substantially collimated light received from the collimation mirror by different amounts for different wavelengths and to provide cross-dispersed light having different wavelengths of light spaced along a first and second axis; and a focus mirror positioned to focus the cross-dispersed light onto a 2-D array detector to provide a plurality of aperture images of the aperture at a respective plurality of regions of the detector, each of the plurality of aperture images associated with a respective wavelength of the cross-dispersed light. Either one or both of the collimation mirror and the focus mirror is a freeform mirror having a reflective surface configured to mitigate effects of optical aberrations of the polychromator system over a plurality of the wavelengths of the cross-dispersed light along the first axis and the second axis and thereby optimise the resolution of the plurality of aperture images associated with the plurality of the wavelengths along the first axis and the second axis.
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公开(公告)号：US11567040B2
公开(公告)日：2023-01-31
申请号：US16760429
申请日：2018-10-26
摘要： Injector (40) for injecting a fluidic sample into a mobile phase in a sample separation apparatus (10), the injector (40) comprising a main flow path (100) between a fluid drive (20) and a sample separation device (30), wherein the fluid drive (20) is adapted to drive the mobile phase and the sample separation device (30) is adapted to separate the fluidic sample that is injected into the mobile phase, a discharge device (104) for discharging an, in particular predetermined, amount of the mobile phase from the main flow path (100), and a supply device (102) for supplying an, in particular predetermined, amount of the fluidic sample and/or of a solvent into the main flow path (100), wherein the discharged amount and the supplied amount compensate each other at least partially.
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公开(公告)号：US20230018079A1
公开(公告)日：2023-01-19
申请号：US17785300
申请日：2020-12-15
发明人： Jurgen DEL FAVERO , Joachim DE SCHRIJVER , Charlotte DE VOGELAERE , Lien HEYRMAN , Dirk GOOSSENS
IPC分类号： C12Q1/6827 , G16B20/00 , G16H50/20 , G16H50/30
摘要： The present disclosure provides methods for detecting or predicting genomic scarring, for use in the field of diagnostic assays and for selecting treatment regimens for human diseases such as cancer.
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公开(公告)号：US20230017417A1
公开(公告)日：2023-01-19
申请号：US17955440
申请日：2022-09-28
发明人： Alan D. LOUX
IPC分类号： B25B23/142 , B25G1/10 , H01J49/10
摘要： In some examples, a multi-device removal and installation tool may include a device removal tool including a first side having a first receiver with a first dimension that removably receives a first device, and a second side having a second receiver with a second dimension that removably receives a second device. The first dimension may be different from the second dimension. A torque limit tool may apply, in a first rotation direction of the torque limit tool and the device removal tool, a tightening torque to the first device. Further, the torque limit tool may apply, in a second rotation direction of the torque limit tool and the device removal tool, a loosening torque to the first device. The second rotation direction may be generally opposite to the first rotation direction.
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公开(公告)号：US20230013904A1
公开(公告)日：2023-01-19
申请号：US17379579
申请日：2021-07-19
发明人： James DELLIS , Lawrence MCCANNEY , Gareth PEARSON
摘要： A tip including an alloy of platinum and an alloying element chosen from gold, palladium, ruthenium, osmium, iron, cobalt, nickel, copper, zinc, silver, chromium, manganese, titanium, niobium, scandium, vanadium, yttrium, zirconium, molybdenum, tantalum, tungsten, technetium, cadmium, hafnium, rhenium, less than 5 wt. % of iridium, less than 5 wt. % of rhodium, greater than 20 wt. % iridium, greater than 20 wt. % rhodium, and a combination thereof, relative to the total weight of the alloy is disclosed. An interface cone can include a base and the tip.
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公开(公告)号：US11557974B2
公开(公告)日：2023-01-17
申请号：US17242077
申请日：2021-04-27
发明人： David Deford
摘要： A high-voltage (HV) power supply outputs an output voltage based on a control signal produced by a dual analog/digital feedback loop. The control signal is determined at least in part by an error amplifier that receives a measurement signal, proportionally attenuated from the output voltage, and a digital-to-analog converter (DAC) output signal. An analog-to-digital converter (ADC) also receives the measurement signal and transmits it in digitized form to a digital processor. The digital processor calculates a digital DAC data signal based on the measurement signal, and on a digital set-point input signal corresponding to a set-point voltage value of the output voltage desired to be outputted from the high-voltage source. A DAC receives the DAC data signal and converts it to the DAC output signal transmitted to the error amplifier.
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