公开(公告)号：US12078619B2

公开(公告)日：2024-09-03

申请号：US17288478

申请日：2018-10-26

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann

IPC分类号： G01N30/20 ,  B01D15/18 ,  G01N30/22 ,  G01N30/46 ,  G01N30/60

CPC分类号： G01N30/20 ,  B01D15/1885 ,  G01N30/22 ,  G01N30/466 ,  G01N30/6043 ,  G01N2030/202 ,  G01N2030/207

摘要： An injector, for injecting a fluidic sample in at least one selected one of a first sample separation apparatus and a second sample separation apparatus, includes a valve arrangement fluidically connectable to the first sample separation apparatus and the second sample separation apparatus, a sample accommodation volume for accommodating the fluidic sample, and a control unit configured for controlling the valve arrangement so that fluidic sample in the sample accommodation volume is selectively injectable into the selected first sample separation apparatus and/or second sample separation apparatus.

公开(公告)号：US11946913B2

公开(公告)日：2024-04-02

申请号：US17730553

申请日：2022-04-27

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Martin Seifried ,  Sam Wouters ,  Irina Spuling

IPC分类号： G01N30/20 ,  G01N30/14 ,  G01N30/32 ,  G01N30/02

CPC分类号： G01N30/20 ,  G01N30/14 ,  G01N30/32 ,  G01N2030/027 ,  G01N2030/326

摘要： An injector is configured for injecting a fluidic sample from an injector path into a mobile phase in a separation path between a fluid drive and a sample separation unit of a sample separation device. The injector includes a control unit configured for generating a first overpressure in a blocked first partial path of the injector path by a first pressure source, for generating a second overpressure in a blocked second partial path of the injector path by a second pressure source, for subsequently fluidically coupling the first partial path with the second partial path for generating an expansion stroke for releasing a gas bubble in the injector path, and for rinsing the released gas bubble from the injector path.

公开(公告)号：US20230210420A1

公开(公告)日：2023-07-06

申请号：US18011127

申请日：2021-06-22

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Michael Lang

IPC分类号： A61B5/15 ,  A61B5/145

CPC分类号： A61B5/15 ,  A61B5/14

摘要： A sampling unit includes a needle for aspirating a sample fluid, a housing, and a fitting. The needle includes a needle tip and a needle channel through the needle for guiding the aspirated sample fluid. The needle channel opens at the needle tip. The housing includes a housing cavity and a housing channel opening into the housing cavity. The fitting includes a fitting cavity and a fitting channel. The fitting is configured for sealingly receiving the needle tip into the fitting cavity and for being inserted into the housing cavity, so that the fitting channel on one side fluidically couples to the needle channel and on another side couples to the housing channel.

公开(公告)号：US20200276728A1

公开(公告)日：2020-09-03

申请号：US16765452

申请日：2018-11-19

申请人： Agilent Technologies, Inc.

发明人： Darijo Zeko ,  Tony Ziegler ,  Thomas Ortmann

IPC分类号： B28B1/00 ,  G01N30/60 ,  G01N30/20 ,  B33Y80/00 ,  B33Y10/00 ,  B33Y70/00 ,  C04B35/10 ,  C04B35/48 ,  B01L3/00

摘要： A microfluidic component for a sample separation apparatus includes a component body including ceramic and at least one microfluidic structure in the component body. The component body is manufactured by additive manufacturing, in particular by three-dimensional printing.

公开(公告)号：US20190390788A1

公开(公告)日：2019-12-26

申请号：US16480600

申请日：2018-01-23

申请人： Agilent Technologies, Inc.

发明人： Tony Ziegler ,  Darijo Zeko ,  Thomas Ortmann

IPC分类号： F16K25/00 ,  F16K11/074 ,  F16K3/04 ,  G01N30/20

摘要： A fluid valve for a sample separation apparatus includes a first valve component and a second valve component, which are adjacent to one another and movable relative to one another. The valve components are configured such that, in at least one switching state, at least one switchable fluid channel is formed between the valve components, and at least one part of a surface of at least one of the first valve component and the second valve component is provided with a coating containing gold and/or platinum.

公开(公告)号：US10371671B2

公开(公告)日：2019-08-06

申请号：US15608888

申请日：2017-05-30

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Daniel Thielsch

IPC分类号： G01N30/20 ,  G01N30/04 ,  G01N30/10 ,  G01N30/36 ,  B01D15/14 ,  G01N30/32

摘要： A sample management device which comprises a source flow path in which a fluidic sample can flow, a volume flow adjustment unit configured to adjust a volume flow of the fluidic sample to be branched off from the source flow path at a fluidic coupling point, and a fluidic valve fluidically coupled with the source flow path and with the volume flow adjustment unit, wherein the fluidic valve is switchable into a branch off state in which the fluidic coupling point is established within the source flow path to branch off an adjustable volume of the fluidic sample from the source flow path via the fluidic coupling point while a flow of the fluidic sample in the source flow path continues.

公开(公告)号：US20240241086A1

公开(公告)日：2024-07-18

申请号：US18562216

申请日：2022-05-17

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Dominik Ruf

IPC分类号： G01N30/22 ,  G01N30/20

CPC分类号： G01N30/22 ,  G01N2030/201 ,  G01N2030/202 ,  G01N2030/204 ,  G01N2030/207

摘要： A switching unit is configured for selectively fluidically coupling a sampling volume, a sampling drive, a mobile phase drive, and a separating device. In a sample load configuration, the switching unit is configured for fluidically coupling the sampling volume and the sampling drive, for moving the fluidic sample into the sampling volume. In a decouple configuration, the switching unit is configured for fluidically coupling the sampling volume between the sampling drive and the separating device, while the mobile phase drive is fluidically decoupled from the separating device. In a sample introduction configuration, the switching unit is configured for fluidically coupling the mobile phase drive, the sampling volume, and the separating device for introducing at least an amount of the fluidic sample stored in the sampling volume into the mobile phase for fluid separation by the separating device.

公开(公告)号：US11931918B2

公开(公告)日：2024-03-19

申请号：US16765452

申请日：2018-11-19

申请人： Agilent Technologies, Inc.

发明人： Darijo Zeko ,  Tony Ziegler ,  Thomas Ortmann

IPC分类号： B28B1/00 ,  B01L3/00 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C04B35/10 ,  C04B35/48 ,  G01N30/20 ,  G01N30/60

CPC分类号： B28B1/001 ,  B01L3/502707 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  C04B35/10 ,  C04B35/48 ,  G01N30/20 ,  G01N30/6095 ,  C04B2235/666 ,  C04B2235/667 ,  G01N2030/202

摘要： A microfluidic component for a sample separation apparatus includes a component body including ceramic and at least one microfluidic structure in the component body. The component body is manufactured by additive manufacturing, in particular by three-dimensional printing.

公开(公告)号：US20230112993A1

公开(公告)日：2023-04-13

申请号：US17913313

申请日：2021-03-15

申请人： Agilent Technologies, Inc.

发明人： Dwight Robert Stoll ,  Stephan Buckenmaier ,  Sascha Lege ,  Thomas Ortmann ,  Konstantin Shoykhet

IPC分类号： G01N30/34 ,  B01D15/14 ,  B01D15/16 ,  G01N30/20 ,  G01N30/46

摘要： A sample separation device for separating a fluidic sample includes a fluid drive for driving a mobile phase and the fluidic sample when injected in the mobile phase, a sample separation unit for separating the fluidic sample in the mobile phase, and a control unit configured for bracketing the fluidic sample between two mobile phase portions of the mobile phase. At least one of the mobile phase portions is arranged directly next to the fluidic sample and has a higher solvent strength compared to a solvent of the fluidic sample.

公开(公告)号：US11519885B2

公开(公告)日：2022-12-06

申请号：US17239238

申请日：2021-04-23

申请人： Agilent Technologies, Inc.

发明人： Thomas Ortmann ,  Michael Lang ,  Blasius Nocon

IPC分类号： G01N30/22 ,  G01N30/02

摘要： A sample injector for a chromatography system is configured for injecting a sample fluid into a mobile phase, and includes a needle and a conduit. The needle is configured for aspirating the sample fluid and includes a needle tip, a needle channel through the needle for guiding the aspirated sample fluid, and a needle opening at the needle tip into which the needle channel opens. The conduit is configured for fluidically coupling with the needle and includes a conduit tip, and a conduit channel through the conduit for guiding fluid and having a conduit opening at the conduit tip. The conduit tip and the needle tip are configured to be pressed against each other for fluidically coupling the conduit channel with the needle channel, with at least a portion of the conduit tip penetrating into the needle opening for providing the fluidic coupling between the conduit and needle channels.