公开(公告)号：US11510627B2

公开(公告)日：2022-11-29

申请号：US16743432

申请日：2020-01-15

申请人： APN Health, LLC

发明人： Xuyong Yu ,  Stephen J. Merrill ,  Jasbir Sra

IPC分类号： A61B5/00 ,  A61B6/00 ,  A61B5/0536 ,  A61B5/352

摘要： An automatic method of categorizing the contact force of a catheter tip against a portion of a patient's heart based on motion of the catheter tip, the method comprising (a) capturing a series of 3D-coordinate data points of the catheter tip as a function of discrete times with a 3D medical imaging system, the 3D coordinates corresponding to an orthogonal 3-axis spatial coordinate system, (b) using a programmable computing system, computing a set of measures based on the series of 3D-coordinate data points, (c) categorizing each measure by a respective set of predetermined threshold values; and (d) combining the categorized measures to yield a relative quality of the contact force.

公开(公告)号：US20160089048A1

公开(公告)日：2016-03-31

申请号：US14497162

申请日：2014-09-25

申请人： APN HEALTH, LLC

发明人： Donald Brodnick ,  Jasbir Sra

IPC分类号： A61B5/04 ,  A61B5/00 ,  A61B5/0408 ,  A61B5/0452 ,  A61B5/0432 ,  A61B5/0464

CPC分类号： A61B5/04015 ,  A61B5/04011 ,  A61B5/04018 ,  A61B5/0408 ,  A61B5/0432 ,  A61B5/0452 ,  A61B5/04525 ,  A61B5/0464 ,  A61B5/7221 ,  A61B5/7246 ,  A61B5/725 ,  A61B5/7257

摘要： An automatic method of determining local activation time (LAT) from at least four multi-channel cardiac electrogram signals including a ventricular channel, a mapping channel and a plurality of reference channels. The method comprises (a) storing the cardiac channel signals, (b) using the ventricular and mapping channel signals and a first reference channel signal to compute LAT values at a plurality of mapping-channel locations, (c) monitoring the timing stability of the first reference channel signal, and (d) if the timing stability of the monitored signal falls below a stability standard, using the signal of a second reference channel to determine LAT values. Substantial loss of LAT values is avoided in spite of loss of timing stability.

摘要翻译： 一种用于从包括心室通道，映射通道和多个参考通道的至少四个多通道心电图信号确定局部激活时间（LAT）的自动方法。 该方法包括：（a）存储心脏信道信号，（b）使用心室和映射信道信号和第一参考信道信号来计算多个映射信道位置处的LAT值，（c）监测 第一参考信道信号，以及（d）如果所监视信号的定时稳定性低于稳定性标准，则使用第二参考信道的信号来确定LAT值。 尽管时间稳定性的损失也避免了LAT值的显着损失。

公开(公告)号：US09078575B2

公开(公告)日：2015-07-14

申请号：US14219826

申请日：2014-03-19

申请人： APN Health, LLC

发明人： Donald Brodnick

IPC分类号： A61B5/04 ,  A61B5/0456 ,  A61B5/0452

CPC分类号： A61B5/04014 ,  A61B5/04011 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/04525 ,  A61B5/0456 ,  A61B5/7239 ,  A61B5/7246 ,  A61B5/7264

摘要： An automatic method for categorizing heartbeats using two or more selected ECG signals, the method comprising, when a heartbeat has been detected, the steps of: (a) determining a signal velocity for each selected signal at a categorization fiducial time tC within the detected heartbeat; (b) forming a vector F(tC) having as its components the velocities of each of the selected signals at time tC; (c) determining the angle between the vector F(tC) and a previously-stored template vector; (d) comparing the angle with a threshold angle; and (e) if the angle is less than the threshold angle, categorizing the heartbeat as similar to a heartbeat which corresponds to the template vector.

摘要翻译： 一种用于使用两个或更多个所选择的ECG信号对心跳进行分类的自动方法，所述方法包括：当检测到心跳时，步骤：（a）在检测到的心跳中的分类基准时间t C下确定每个选定信号的信号速度 ; （b）在时刻tC形成具有各选择信号的速度的矢量F（tC）; （c）确定矢量F（tC）和先前存储的模板矢量之间的角度; （d）将角度与阈值角度进行比较; 和（e）如果角度小于阈值角度，将心跳分类为类似于对应于模板向量的心跳。

公开(公告)号：US20130245477A1

公开(公告)日：2013-09-19

申请号：US13607185

申请日：2012-09-07

申请人： Donald Brodnick ,  David G. Jansson

发明人： Donald Brodnick ,  David G. Jansson

IPC分类号： A61B5/0456

CPC分类号： A61B5/0456 ,  A61B5/061 ,  A61B5/7289 ,  A61B6/022 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/463 ,  A61B6/485 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5264 ,  A61B6/5288 ,  A61B6/582 ,  A61B2034/2065 ,  A61B2090/367 ,  A61B2090/376

摘要： A method for detecting an R-wave from an ECG signal (x(t)) derived from a living body, the method comprising the steps of (a) acquiring the ECG signal from the living body, (b) digitizing the ECG signal into a digital ECG signal (x(ti)), (c) filtering the digital ECG signal with a bandpass filter (53) and applying an absolute value filter (55) thereto to create a filtered ECG signal (g(ti)), (d) for each sequential value of the filtered ECG signal, comparing (57) the filtered ECG signal to an ECG tracking threshold (TT), (e) if the filtered ECG signal is no greater than TT, incrementing a counter (59), but if greater than TT, setting the counter to zero; and (f) comparing (63) the counter to a predetermined refractory count RC and, if the count is equal to RC, outputting an R-wave trigger indicating that an R-wave has been detected.

摘要翻译： 一种用于从源自生物体的ECG信号（x（t））检测R波的方法，所述方法包括以下步骤：（a）从活体获取ECG信号，（b）将ECG信号数字化为 数字ECG信号（x（ti）），（c）用带通滤波器（53）对数字ECG信号进行滤波，并向其施加绝对值滤波器（55）以产生滤波后的ECG信号（g（ti）），（ d）对于经滤波的ECG信号的每个顺序值，将经滤波的ECG信号与ECG跟踪阈值（TT）进行比较（e）如果滤波的ECG信号不大于TT，增加计数器（59） 但如果大于TT，则将计数器设置为零; 和（f）将计数器与预定难治性计数RC进行比较（63），并且如果计数等于RC，则输出指示已经检测到R波的R波触发。

公开(公告)号：US20200222006A1

公开(公告)日：2020-07-16

申请号：US16743432

申请日：2020-01-15

申请人： APN Health, LLC

发明人： Xuyong Yu ,  Stephen J. Merrill ,  Jasbir Sra

IPC分类号： A61B5/00 ,  A61B5/0456 ,  A61B6/00 ,  A61B5/053

摘要： An automatic method of categorizing the contact force of a catheter tip against a portion of a patient's heart based on motion of the catheter tip, the method comprising (a) capturing a series of 3D-coordinate data points of the catheter tip as a function of discrete times with a 3D medical imaging system, the 3D coordinates corresponding to an orthogonal 3-axis spatial coordinate system, (b) using a programmable computing system, computing a set of measures based on the series of 3D-coordinate data points, (c) categorizing each measure by a respective set of predetermined threshold values; and (d) combining the categorized measures to yield a relative quality of the contact force.

公开(公告)号：US20180296117A1

公开(公告)日：2018-10-18

申请号：US15924761

申请日：2018-03-19

申请人： Jasbir Sra ,  Barry Belanger ,  Mark Paulma ,  Donald Brodnick ,  Bruce Langenbach

发明人： Jasbir Sra ,  Barry Belanger ,  Mark Paulma ,  Donald Brodnick ,  Bruce Langenbach

IPC分类号： A61B5/0456 ,  A61B6/00 ,  A61B5/06 ,  A61B5/00 ,  A61B6/12 ,  A61B6/02 ,  A61B90/00 ,  A61B34/20

摘要： A method for automatically determining the 3D position and orientation of a radio-opaque medical object in a living body using single-plane fluoroscopy comprising: (a) capturing a stream of digitized 2D images from a single-plane fluoroscope; (b) detecting an image of the medical object in a subset of the digital 2D images; (c) applying to the digital 2D images calculations which preserve original pixel intensity values and permit statistical calculations thereon, using (i) multiple sequential determinations of a midline of the medical object image, (ii) a plurality of unfiltered raw-data cross-sectional intensity profiles perpendicular to each sequentially-determined midline, (iii) removal of outlier profiles from each plurality of profiles, and (iv) statistically combining each plurality of profiles to estimate image dimensions, thereby to measure the medical-object image from a final estimation of image dimensions; (d) applying conical projection and radial elongation corrections to the image measurements; and (e) calculating the 3D position and orientation of the medical object from the corrected 2D image measurements.

公开(公告)号：US20170251942A1

公开(公告)日：2017-09-07

申请号：US15062697

申请日：2016-03-07

申请人： APN Health, LLC

发明人： Donald Brodnick ,  Jasbir Sra

IPC分类号： A61B5/04 ,  A61B5/0408 ,  A61B5/0468

CPC分类号： A61B5/04012 ,  A61B5/04017 ,  A61B5/04085 ,  A61B5/0468 ,  A61B5/7221

摘要： An automatic method of determining local activation time (LAT) from at least three multi-channel cardiac electrogram signals including a mapping channel and a plurality of reference channels. The method comprises (a) storing the cardiac channel signals, (b) using the mapping-channel signal and a first reference-channel signal to compute LAT values at a plurality of mapping-channel locations, (c) monitoring the timing stability of the first reference-channel signal, and (d) if the timing stability of the monitored signal falls below a stability standard, using the signal of a second reference channel to determine LAT values. Substantial loss of LAT values is avoided in spite of loss of timing stability.

公开(公告)号：US09078572B2

公开(公告)日：2015-07-14

申请号：US14067561

申请日：2013-10-30

申请人： APN Health, LLC

发明人： Donald Brodnick

IPC分类号： A61B5/04 ,  A61B5/044 ,  A61B5/0456

CPC分类号： A61B5/0456 ,  A61B5/04017 ,  A61B5/7239 ,  A61B5/7264

摘要： An automatic method for detecting heartbeats of a patient from two or more selected ECG signals, the method comprising: (a) determining a velocity for each of the selected signals; (b) summing together absolute values of each of the velocities; (c) comparing the sum with a threshold T having a value about one-half of an expected maximum value of the sum; and (d) if the sum is greater than the threshold T and if elapsed time since an immediately-previous heartbeat detection is greater than a preset refractory period tR, a heartbeat has been detected at a time tD of the velocity determinations. The method also further includes steps by which the detected heartbeats are categorized based on the velocities at the time of detection.

摘要翻译： 一种用于从两个或更多个选择的ECG信号中检测患者的心跳的自动方法，所述方法包括：（a）确定每个所选信号的速度; （b）将每个速度的绝对值相加; （c）将所述和与阈值T进行比较，所述阈值T大约为所述和的预期最大值的一半; 和（d）如果总和大于阈值T，并且如果从紧前一次心跳检测以来的经过时间大于预设的不良期tR，则在速度确定的时刻tD检测到心跳。 该方法还包括基于检测时的速度对检测到的心跳进行分类的步骤。

公开(公告)号：US09014794B2

公开(公告)日：2015-04-21

申请号：US14274078

申请日：2014-05-09

申请人： Donald Brodnick ,  David G. Jansson

发明人： Donald Brodnick ,  David G. Jansson

IPC分类号： A61B5/04 ,  A61B5/0456 ,  A61B5/06 ,  A61B6/12 ,  A61B6/00 ,  A61B6/02 ,  A61B19/00

CPC分类号： A61B5/0456 ,  A61B5/061 ,  A61B5/7289 ,  A61B6/022 ,  A61B6/12 ,  A61B6/4441 ,  A61B6/463 ,  A61B6/485 ,  A61B6/487 ,  A61B6/503 ,  A61B6/5264 ,  A61B6/5288 ,  A61B6/582 ,  A61B2034/2065 ,  A61B2090/367 ,  A61B2090/376

摘要： A method for detecting an R-wave from an ECG signal derived from a living body, the ECG signal including a plurality of ECG channel signals, the method comprising the steps of providing a plurality of channel R-wave detectors each processing a distinct signal of the plurality of channel ECG signals to generate a distinct channel trigger signal of a plurality of channel trigger signals, and inputting each channel trigger signal into a composite R-wave detector to generate a composite R-wave trigger, whereby the composite R-wave detector more accurately detects R-waves than each of the plurality of channel R-wave detectors.

摘要翻译： 一种用于从生物体获得的ECG信号中检测R波的方法，所述ECG信号包括多个ECG信道信号，所述方法包括以下步骤：提供多个信道R波检测器，每个信道R波检测器处理 多个信道ECG信号以产生多个信道触发信号的不同信道触发信号，并将每个信道触发信号输入到复合R波检测器中以产生复合R波触发，由此复合R波检测器 比每个多个通道R波检测器更精确地检测R波。

公开(公告)号：US08812091B1

公开(公告)日：2014-08-19

申请号：US13922953

申请日：2013-06-20

申请人： APN Health, LLC

发明人： Donald Brodnick

IPC分类号： A61B5/04

CPC分类号： A61B5/04017 ,  A61B5/02405 ,  A61B5/0245 ,  A61B5/04012 ,  A61B5/0422 ,  A61B5/0456 ,  A61B5/0468 ,  A61B5/7221 ,  A61B5/7239 ,  A61B5/7246 ,  A61B2505/05

摘要： An automatic method of determining local activation time (LAT) in multi-channel cardiac electrogram signals including a plurality of cardiac channels, the method comprising: (a) storing the cardiac channel signals; (b) selecting a mapping channel, a ventricular channel, and a reference channel from among the plurality of cardiac channels; (c) using the selected channels to compute first LAT values at a plurality of mapping-channel locations; (d) monitoring the quality of at least one selected channel; (e) if the quality of a monitored cardiac channel falls below a standard, replacing the sub-standard channel with another channel of the plurality of channels having an above-standard quality; and (f) computing second LAT values based on the replacement cardiac channel.

摘要翻译： 一种确定包括多个心脏通道的多通道心电图信号中的局部激活时间（LAT）的自动方法，所述方法包括：（a）存储心脏通道信号; （b）从所述多个心脏通道中选择映射信道，心室信道和参考信道; （c）使用所选择的信道来计算多个映射信道位置处的第一LAT值; （d）监测至少一个所选频道的质量; （e）如果所监视的心脏通道的质量低于标准，则用具有高于标准质量的多个通道中的另一个通道代替子标准通道; 和（f）基于替换心脏通道计算第二LAT值。