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公开(公告)号：US20240262825A1
公开(公告)日：2024-08-08
申请号：US18602482
申请日：2024-03-12
申请人： BIONOMICS LIMITED
发明人： Belinda HUFF , Courtney HOLLIS , Hamish TOOP , Nathan KUCHEL , Lorna Helen MITCHELL , Rajinder SINGH , Thomas AVERY , Celine MICHAUT-SIMON , Jean-Marie CONTRERAS , Christophe MORICE
IPC分类号： C07D471/04 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/34 , C07D241/24 , C07D249/10 , C07D271/06 , C07D277/56 , C07D487/04
CPC分类号： C07D471/04 , C07D213/81 , C07D213/82 , C07D231/14 , C07D239/34 , C07D241/24 , C07D249/10 , C07D271/06 , C07D277/56 , C07D487/04
摘要： The present invention relates to compounds useful in the modulation of ion channel activity in cells. The invention also relates to use of these compounds in the treatment of pain, and pharmaceutical compositions containing these compounds and methods for their preparation.
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公开(公告)号：US11478445B2
公开(公告)日：2022-10-25
申请号：US16758787
申请日：2018-10-17
申请人： Bionomics Limited
发明人： Tina Lavranos
IPC分类号： A61K31/343 , A61P35/02 , A61K31/665
摘要： The present invention relates to a method for the treatment of acute myeloid leukemia (AML) with medicaments useful for same. The medicaments can be pharmaceutical compositions or kits comprising compounds of the presently-described formula (I) or a salt, solvate or prodrug thereof. Specific compounds of the invention include 2-methyl-7-hydroxy-3-(3,4,5-trimethoxybenzoyl)-6-methoxybenzofuran which is also known as BNC105 and disodium 6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzofuran-7-yl phosphate which is also known as BNC105P.
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公开(公告)号：US20220112176A1
公开(公告)日：2022-04-14
申请号：US17441637
申请日：2019-10-30
申请人： Bionomics Limited
发明人： Hamish Toop , Dharam Paul , Rajinder Singh , Erin Smith , Patrick Bazzini , Jean-Marie Contreras , Christophe Morice , Laurent Schaeffer , Celine Michaut-Simon , Florence Chery , Fabrice Garrido
IPC分类号： C07D403/04 , C07D401/14 , C07D405/14
摘要： The present disclosure relates generally to compounds useful for the treatment and/or enhancement of cognitive function and negative symptoms associated with central nervous system disorders where the circuitry involving fast spiking PV+ interneurons and the production of cortical gamma oscillations is disrupted. The subject disclosure enables the manufacture of medicaments as well as compositions containing same for use in methods of therapy and prophylaxis of cognitive dysfunction and negative symptoms.
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公开(公告)号：US20210148894A1
公开(公告)日：2021-05-20
申请号：US17046719
申请日：2019-04-12
申请人： Bionomics Limited
发明人： Tina LAVRANOS , Kristen GEORGIOU
IPC分类号： G01N33/50 , G01N33/574
摘要： The present invention relates to the field of pharmacogenomics. In particular, provided herein is the use of pharmacodynamics markers in a method of monitoring the response of a subject to cancer treatment, wherein the cancer treatment comprises a Wnt/β-catenin signalling modulator (preferably an allosteric modulator of LGR5 receptor) and the monitoring comprises determining the ratio of Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitor of Metalloproteinases 1 (TIMP-1) expression levels in a sample obtained from the subject.
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公开(公告)号：US10213409B2
公开(公告)日：2019-02-26
申请号：US15141170
申请日：2016-04-28
申请人： Bionomics Limited
发明人： Jason Hugh Chaplin , Gurmit Sing Gill , Damian Wojciech Grobelny , Bernard Luke Flynn , Gabriel Kremmidiotis
IPC分类号： A61K31/343 , C07D209/12 , C07D307/80 , C07D307/81 , C07D307/82 , C07D307/83 , C07D307/84 , C07D307/85 , C07D307/86 , C07D333/56 , C07D405/06 , C07D407/06 , C07D407/12 , C07D405/12 , C07F9/655 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/4178 , A61K31/443 , A61K31/496 , A61K31/665 , A61K39/395 , A61K45/06 , A61K51/00 , C07K16/22
摘要： The present invention relates generally to substituted benzofurans, benzothiophenes, and indoles and their use as tubulin polymerization inhibitors.
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公开(公告)号：US10159659B2
公开(公告)日：2018-12-25
申请号：US15322647
申请日：2015-03-18
申请人： BIONOMICS LIMITED
发明人： Jose Iglesias
IPC分类号： A61K31/34 , A61K31/343 , C12Q1/48 , A61K31/439
摘要： The present invention relates to cancer markers that are predictive for cancer patent response to treatment with an m TOR inhibitor and a vascular disrupting agent. The present invention further relates to methods of treating a cancer patient subpopulation with a combination of an m TOR inhibitor and a vascular disrupting agent.
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公开(公告)号：US10137105B2
公开(公告)日：2018-11-27
申请号：US15554917
申请日：2016-03-02
申请人： Bionomics Limited
IPC分类号： A61K31/343 , A61K31/519 , A61K45/06
摘要： The present disclosure provides a combination and a method for treating chronic lymphocytic leukemia (CLL).
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公开(公告)号：US20180196048A1
公开(公告)日：2018-07-12
申请号：US15322845
申请日：2015-07-02
申请人： BIONOMICS LIMITED
IPC分类号： G01N33/574 , A61K31/343 , A61K45/06 , A61P35/00
CPC分类号： G01N33/574 , A61K31/343 , A61K31/436 , A61K45/06 , A61P35/00 , G01N2333/475 , G01N2333/805 , G01N2333/96494 , G01N2800/52 , A61K2300/00
摘要： The present disclosure relates to the biological markers SAP, SHBG, Myoglobin, MMP-9, and SCF that are predictive for patient response to treatment with a vascular disrupting agent. In particular, the present disclosure relates to biological markers predictive for cancer patient response to treatment with a vascular disrupting agent, as well as methods of treating a cancer patient with a vascular disrupting agent.
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公开(公告)号：US09758516B2
公开(公告)日：2017-09-12
申请号：US14776595
申请日：2013-05-14
申请人： Bionomics Limited
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07B2200/13
摘要： A crystalline Form B of compound 1 can be used in pharmaceutically compositions. The pharmaceutical compositions can be used in methods of treating a disease (e.g., a disease of the central nervous system).
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公开(公告)号：US20160039810A1
公开(公告)日：2016-02-11
申请号：US14776595
申请日：2013-05-14
申请人： BIONOMICS LIMITED
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C07B2200/13
摘要： A crystalline Form B of compound 1 can be used in pharmaceutically compositions. The pharmaceutical compositions can be used in methods of treating a disease (e.g., a disease of the central nervous system).
摘要翻译： 化合物1的晶型B可用于药物组合物中。 药物组合物可用于治疗疾病（例如中枢神经系统疾病）的方法。
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