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公开(公告)号：US20240352542A1
公开(公告)日：2024-10-24
申请号：US18628273
申请日：2024-04-05
发明人： Julien Wist , Samuele Sala , Philipp Nitschke , Jeremy K. Nicholson , Elaine Holmes , Christoph Trautwein , Claire Cannet
IPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
CPC分类号： C12Q1/70 , C12Q1/6872 , C12Q1/6876
摘要： The invention relates to the field of viral diagnosis. In particular, it is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (a) determining in a sample of said subject the amount of at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (b) comparing the amount(s) of the at least one biomarkers determined in (a) with a reference, thereby diagnosing a viral infection.
Further, the invention is directed to a method for diagnosing a viral infection or a disease associated therewith in a subject comprising the steps of: (A) determining in a sample of said subject the amount of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC); and (B) comparing the amount of the ddhC determined in (A) with a reference, thereby diagnosing a viral infection; wherein the determination in (a) is done by NMR spectroscopy and the sample of the subject is a urine sample of said subject.
The invention is also related to a diagnostic means for use in diagnosing a viral infection or a disease associated therewith, said diagnostic means comprising at least one biomarker selected from the group of 3′(,5′-di)deoxy-3′,4′-didehydro furanose derivatives of formula (I) with the exception of 3′-deoxy-3′,4′-didehydro-cytidine (ddhC), but also to a diagnostic means comprising 3′-deoxy-3′,4′-didehydro-cytidine (ddhC) for use in diagnosing a viral infection or a disease associated therewith, wherein the amount of the biomarker is determined done by NMR spectroscopy in a urine sample of a subject.
Furthermore, the invention is directed to a device for diagnosing a viral infection or a disease associated therewith in a sample of a subject and to a kit for identifying a subject suffering from a viral infection or a disease associated therewith.-
公开(公告)号：US11874241B2
公开(公告)日：2024-01-16
申请号：US17847348
申请日：2022-06-23
申请人： Bruker BioSpin GmbH
发明人： Alexander Krahn , Franck Vincent
CPC分类号： G01N24/08 , G01N24/10 , G01R33/34092
摘要： The invention relates to a sample cell for performing DNP-NMR measurements, for interchangeable use in an EPR microwave resonator, with the sample cell comprising
a flat sample cavity for holding a liquid sample to be measured, wherein the flat sample cavity extends with a maximum length L and a maximum width W in a sample cavity plane, and extends with a maximum height H perpendicular to the sample cavity plane, with H≤ 1/15*L and H≤ 1/15*W, and
an NMR coil wound around the flat sample cavity for generating an RF magnetic field B2, wherein a coil axis of the NMR coil about which the NMR coil is wound is oriented perpendicular to the sample cavity plane. The invention provides a sample cell which is easy to handle and improves the quality and the reproducibility of DNP-NMR measurements.-
公开(公告)号：US11561274B1
公开(公告)日：2023-01-24
申请号：US17929488
申请日：2022-09-02
申请人： Bruker BioSpin GmbH
发明人： Michael Maixner
IPC分类号： G01R33/60
摘要： A microwave bridge circuit routes a transmission signal from a transmitter to a resonator and forwards the reception signal generated in the resonator to a receiver. It includes two electrical lines connected in parallel at a first circuit point TX, where the transmission signal is divided. The first electrical line has an attenuator for attenuating a first transmission signal portion. The second electrical line carries a second transmission signal portion and connects to the resonator at a second circuit point R, which divides it between section L1, which runs from TX to R, and section L2, which runs from R to a third circuit point RX. The length of the sections L1 and L2 corresponds to an odd integer multiple of one quarter of the wavelength of the transmission signal, and the divided transmission signal portions are combined at RX, where the reception signal is forwarded to the receiver.
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4.发明申请公开(公告)号：US20220196775A1
公开(公告)日：2022-06-23
申请号：US17537935
申请日：2021-11-30
申请人： Bruker BioSpin GmbH
发明人： Ion PRISECARU , Lukas HAENICHEN
摘要： An electron paramagnetic resonance (EPR) spectrometer includes a magnet system comprising at least one magnet and at least one pole piece for producing a magnetic field along a pole axis in a field of view in front of the at least one pole piece. A probe head comprising a microwave resonator and at least one modulation coil or rapid scan coil produces an additional, time-varying magnetic field aligned along the pole axis. The probe head is arranged in the field of view, and a respective modulation coil or rapid scan coil is arranged between the microwave resonator and a respective pole piece. For each pole piece, at least a part of said pole piece is made of a function material having an electric conductivity σf of 104 S/m or less, and having a saturation magnetic flux density BSf of 0.2 T or more.
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公开(公告)号：US20210262957A1
公开(公告)日：2021-08-26
申请号：US17248591
申请日：2021-01-29
申请人： Bruker BioSpin GmbH
IPC分类号： G01N24/08
摘要： A system, method and computer program product for detecting indicators for structural changes of NMR active test molecules in a test sample, or indicators for structural changes of the environment of said test molecules in relation to a reference molecule. Initial local similarity values are obtained, using a similarity function and representing a local similarity between a reference spectrum and a test spectrum within corresponding similarity regions (SRR, SRT). The initial local similarity values represent a similarity map (SM1) in which contours of a first shape type are indicators (I1) for structural changes of the test molecule, and in which contours of a second shape type are indicators (I2) for structural changes of the environment of said test molecule in relation to the reference molecule.
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公开(公告)号：US11079457B2
公开(公告)日：2021-08-03
申请号：US16933222
申请日：2020-07-20
申请人： Bruker BioSpin GmbH
发明人： Ion Prisecaru , Peter Höfer
摘要： A microwave resonator for an electron paramagnetic resonance probehead comprises a cavity body supporting an electromagnetic microwave resonance mode, at least one sample opening for inserting a sample in a sample container, at least one microwave opening for transmitting microwave radiation into the resonator, and at least one access opening for inserting and removing a modifier in a modifier vessel into or out of the cavity body. The modifier vessel is fixed in the at least one access opening, the modifier is a fluid comprising attenuator fluid and/or marker fluid and/or adaptor fluid, and the modifier vessel has an insert opening for filling and discharging the modifier gradually into or out of the cavity body. This improves performance greatly, enabling a gradual modification of specific experimental conditions without moving any mechanical parts in the cavity body, and without changing other experimental conditions for Q- and/or M- and/or D-variation.
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公开(公告)号：US10976391B2
公开(公告)日：2021-04-13
申请号：US16693832
申请日：2019-11-25
申请人： Bruker BioSpin GmbH
发明人： Rainer Pietig , Volker Niemann , Lukas Haenichen
IPC分类号： G01R33/383 , H01F7/02 , G01R33/387
摘要： A magnet arrangement having a hollow-cylindrical magnet element that has an axial length Lz,M and an inner radius Rin, is constructed from magnet segments arranged concentrically around the z-axis, and has a Halbach magnetization. At least one ring-shaped magnet element has a notched, hollow-cylindrical cutout extending circumferentially around the z-axis symmetrically with respect to the plane z=0, the axial extent Lz,A of the cutout being less than the axial length Lz,M of the magnet element. The cutout has a radial depth TA and an axial length Lz,A
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公开(公告)号：US10578694B2
公开(公告)日：2020-03-03
申请号：US16444519
申请日：2019-06-18
申请人： Bruker BioSpin GmbH
发明人： Christian Fischer , Markus Lang , Martin Wyser , Klaus Peter Neidig , Michael Erich Wilhelm Fey
摘要： Systems and methods for improved NMR signal detection are described. The system receives NMR signal data produced by a sample over time in response to an excitation pulse and selects a predefined system function for application to the NMR signal data for systematic variation of signal properties The system function has a different influence on NMR signal components than on noise components of the sampled signal and has a variation parameter to control the systematic variation. A plurality of variation parameter values is provided with differing values to influence broad NMR signals as well as weak NMR signals. The system generates for each variation parameter value a corresponding intermediate data set by applying the system function with the respective variation parameter value to the NMR signal data. Further, from each intermediate data set, a respective base value centered spectrum is generated in the frequency-domain.
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公开(公告)号：US10203067B2
公开(公告)日：2019-02-12
申请号：US14849661
申请日：2015-09-10
申请人： Bruker BioSpin GmbH
发明人： Marco Strobel
摘要： A cryostat has a cooling arm with a first thermal contact surface which can be brought into thermal contact with a second thermal contact surface on an object to be cooled. A hollow volume (2) between the inner side of the neck tube, the cooling arm, and the object is filled with gas and the cooling arm is pressurized by the inner pressure of the gas and also by atmospheric pressure. A contact device brings the first and the second contact surfaces into thermal contact below a threshold gas pressure and moves them away from each other when the threshold pressure has been exceeded such that a gap (13) filled with gas thermally separates the first and second contact surfaces. Operationally safe and fully automatic reduction of the thermal load acting on the object to be cooled is thereby obtained in case the cooling machine fails.
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公开(公告)号：US10120044B2
公开(公告)日：2018-11-06
申请号：US14910706
申请日：2014-07-23
申请人： BRUKER BIOSPIN GMBH
发明人： Armin Purea , Frank Engelke , Alexander Krahn
IPC分类号： G01R33/345 , G01R33/28 , G01R33/30 , G01N24/08 , G01R33/62
摘要： An NMR DNP-MAS probe head (10) has an MAS stator (2) for receiving an MAS rotor (3) having a sample substance in a sample volume (4), and a hollow microwave waveguide (5)′ for feeding microwave radiation through an opening (5a) of the microwave waveguide into the sample volume, an axially expanded rod-shaped microwave coupler (6) located in the opening made of dielectric material, characterized in that the microwave waveguide has a conically tapered hollow transition piece for coupling in an HE 11 mode, into which the microwave coupler projects at an all-round radial distance to the opening of the microwave waveguide. It is thus possible, in a surprisingly simple manner and by means of readily available technical means, to irradiate a considerably higher microwave energy in the HE 11 mode into the NMR measuring sample than by means of the known arrangements.
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