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公开(公告)号：US20170218345A1
公开(公告)日：2017-08-03
申请号：US15305870
申请日：2015-04-17
申请人： C-LEcta GmbH
发明人： Ramona Schmiedel , Andreas Vogel , Sabrina Koepke , Rico Czaja , Claudia Feller , Hedda Merkens , Kamila Rzeznicka , Daniel Schwarze , Thomas Greiner-Stoeffele , Andreas Petri , Marc Struhalla
CPC分类号： C12N9/0006 , C12P7/02 , C12P7/24 , C12P7/26 , C12P7/40 , C12Y101/01001 , C12Y101/01184
摘要： The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral secondary alcohols.
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公开(公告)号：US20230193220A1
公开(公告)日：2023-06-22
申请号：US17811933
申请日：2022-07-12
申请人： C-Lecta GmbH , New Matterhorn, LLC
CPC分类号： C12N9/1051 , C12N9/92 , C12P19/12 , C12P19/18 , C12P19/24 , C12Y204/01007 , C12Y204/01064
摘要： The present invention relates to a method for producing trehalose, comprising the steps of mixing and reacting, in any order, (i) at least one alpha-phosphorylase capable of catalyzing the production of alpha-D-glucose 1-phosphate intermediate from a saccharide raw material, and from at least one phosphorus source; (ii) at least one trehalose phosphorylase capable of catalyzing the production of trehalose from an alpha-D-glucose 1-phosphate intermediate and a glucose substrate, wherein the trehalose phosphorylase is a trehalose phosphorylase variant with an amino acid sequence which differs from the amino acid sequence of a wild type trehalose phosphorylase in at least one amino acid position, (iii) at least one saccharide raw material which produces an alpha-D-glucose 1-phosphate intermediate and a co-product by catalytic action of the alpha-phosphorylase; and (iv) at least one phosphorus source selected from the group consisting of a phosphoric acids and an inorganic salt thereof.
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公开(公告)号：US10724008B2
公开(公告)日：2020-07-28
申请号：US16117296
申请日：2018-08-30
申请人： C-LEcta GmbH
发明人： Ramona Schmiedel , Andreas Vogel , Sabrina Koepke , Rico Czaja , Claudia Feller , Hedda Merkens , Kamila Rzeznicka , Daniel Schwarze , Thomas Greiner-Stoeffele , Andreas Petri , Marc Struhalla
摘要： The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral secondary alcohols.
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4.发明申请Method for Producing Nucleases of a Gram Negative Bacterium While Using a Gram Positive Expression Host 有权使用革兰氏阳性表达宿主产生革兰氏阴性细菌核苷酸的方法公开(公告)号：US20120135498A1
公开(公告)日：2012-05-31
申请号：US13364889
申请日：2012-02-02
CPC分类号： C12P21/02 , C07K2319/036 , C07K2319/21 , C07K2319/22 , C07K2319/24 , C12N9/22
摘要： A method for producing a nuclease of a gram negative bacterium or a nuclease preparation containing a nuclease of a gram negative bacterium including expression of the nuclease in a gram positive bacterium and subsequent secretion of the nuclease, as well as a nuclease or a nuclease preparation that can be obtained by this method.
摘要翻译： 一种生产革兰氏阴性细菌的核酸酶或含有革兰氏阴性细菌的核酸酶的核酸酶的方法，包括在革兰氏阳性菌中表达核酸酶，随后分泌核酸酶，以及核酸酶或核酸酶制剂， 可以通过这种方法获得。
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公开(公告)号：US20230304055A1
公开(公告)日：2023-09-28
申请号：US18011258
申请日：2021-06-29
申请人： C-LEcta GmbH
摘要： The invention relates to a process for the preparation of a glycosylated organic compound by in vitro glycosylation of an organic compound having a nucleophilic group with a saccharide under catalysis of a Leloir glycosyltrans-ferase system comprising at least a first glycosyl transferase and a second glycosyl transferase. The invention further relates to a composition comprising a glycosylated organic compound that is obtainable by the process according to the invention.
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公开(公告)号：US10774356B2
公开(公告)日：2020-09-15
申请号：US15735170
申请日：2016-06-10
申请人： C-LEcta GmbH
发明人： Andreas Vogel , Daniel Schwarze , Rico Czaja , Sally Bayer , Sebastian Bartsch
摘要： The invention relates to transaminases and their use. The ATAs according to the invention are particularly useful for catalyzing the conversion of amines to ketones and/or vice versa. Preferably, the transaminase (ATA) according to the invention comprises an amino acid sequence with at least 80% homology to SEQ ID NO:1, wherein the amino acid sequence is engineered compared to SEQ ID NO:1 such that it comprises at least a substitution selected from the group consisting of F255L, F255A, F255C, F255D, F255E, F255G, F255H, F255K, F255M, F255N, F255P, F255Q, F255R, F255S, F255T, F255V, F255W, and F255Y.
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公开(公告)号：US20190078130A1
公开(公告)日：2019-03-14
申请号：US15735170
申请日：2016-06-10
申请人： C-LEcta GmbH
发明人： Andreas Vogel , Daniel Schwarze , Rico Czaja , Sally Bayer , Sebastian Bartsch
摘要： The invention relates to transaminases and their use. The ATAs according to the invention are particularly useful for catalyzing the conversion of amines to ketones and/or vice versa. Preferably, the transaminase (ATA) according to the invention comprises an amino acid sequence with at least 80% homology to SEQ ID NO:1, wherein the amino acid sequence is engineered compared to SEQ ID NO:1 such that it comprises at least a substitution selected from the group consisting of F255L, F255A, F255C, F255D, F255E, F255G, F255H, F255K, F255M, F255N, F255P, F255Q, F255R, F255S, F255T, F255V, F255W, and F255Y.
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公开(公告)号：US20190062714A1
公开(公告)日：2019-02-28
申请号：US16117296
申请日：2018-08-30
申请人： C-LEcta GmbH
发明人： Ramona Schmiedel , Andreas Vogel , Sabrina Koepke , Rico Czaja , Claudia Feller , Hedda Merkens , Kamila Rzeznicka , Daniel Schwarze , Thomas Greiner-Stoeffele , Andreas Petri , Marc Struhalla
CPC分类号： C12N9/0006 , C12P7/02 , C12P7/24 , C12P7/26 , C12P7/40 , C12Y101/01001 , C12Y101/01184
摘要： The invention relates to ketoreductases and the use thereof. The ketoreductases of the invention are particularly useful for enzymatically catalyzing the reduction of ketones to chiral secondary alcohols.
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公开(公告)号：US11421207B2
公开(公告)日：2022-08-23
申请号：US16761735
申请日：2018-11-28
申请人： C-Lecta GmbH , New Matterhorn, LLC
摘要： The present invention relates to a method for producing trehalose, comprising the steps of mixing and reacting, in any order, (i) at least one alpha-phosphorylase capable of catalyzing the production of alpha-D-glucose 1-phosphate intermediate from a saccharide raw material, and from at least one phosphorus source; (ii) at least one trehalose phosphorylase capable of catalyzing the production of trehalose from an alpha-D-glucose 1-phosphate intermediate and a glucose substrate, wherein the trehalose phosphorylase is a trehalose phosphorylase variant with an amino acid sequence which differs from the amino acid sequence of a wild type trehalose phosphorylase in at least one amino acid position, (iii) at least one saccharide raw material which produces an alpha-D-glucose 1-phosphate intermediate and a co-product by catalytic action of the alpha-phosphorylase; and (iv) at least one phosphorus source selected from the group consisting of a phosphoric acids and an inorganic salt thereof.
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公开(公告)号：US20210380954A1
公开(公告)日：2021-12-09
申请号：US17303916
申请日：2021-06-10
申请人： C-Lecta GmbH , New Matterhorn, LLC
发明人： Birgit Brucher , Andreas Vogel
摘要： The present invention is related to a trehalose phosphorylase comprising an amino acid sequence, wherein the amino acid sequence of the trehalose phosphorylase is at least 80% identical to and/or at least 80% homologous to an amino acid sequence of SEQ ID NO: 1, wherein the amino acid sequence of the trehalose phosphorylase comprises an amino acid substitution at one or more amino acid positions, wherein the one or more amino acid positions is/are selected from the group consisting of amino acid positions of SEQ ID NO: 1712, 383, 10, 114, 118, 192, 197, 220, 225, 304, 306, 318, 323, 339, 349, 357, 459, 476, 481, 484, 487, 488, 506, 511, 526, 530, 532, 533, 537, 550, 556, 564, 590, 649, 667, 703 and 705.
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