公开(公告)号：US08663701B2

公开(公告)日：2014-03-04

申请号：US13925435

申请日：2013-06-24

申请人： Epitech Group S.r.l.

发明人： Francesco Della Valle ,  Gabriele Marcolongo ,  Maria Federica Della Valle

IPC分类号： A61K9/14

CPC分类号： A61K9/14 ,  A61K9/0056 ,  A61K9/0095 ,  A61K9/2013 ,  A61K9/209 ,  A61K9/4858 ,  A61K31/05 ,  A61K31/16 ,  A61K31/164 ,  A61K31/352 ,  Y02A50/40 ,  A61K2300/00

摘要： The present invention relates to a composition for pharmaceutical or veterinary use, comprising palmitoylethanolamide. In particular, the present invention relates to a pharmaceutical composition for human or veterinary use, containing a therapeutically efficient amount of palmitoylethanolamide in the ultra-micronized form, wherein more than 90% by weight of palmitoylethanolamide has particle sizes lower than 6 microns, together with pharmaceutically acceptable excipients.

摘要翻译： 本发明涉及用于药物或兽医用途的组合物，其包含棕榈酰乙醇酰胺。 特别地，本发明涉及一种用于人或兽用药物的药物组合物，其含有超微粉化形式的治疗有效量的棕榈酰乙醇酰胺，其中超过90重量％的棕榈酰乙醇酰胺具有小于6微米的粒度，以及 药学上可接受的赋形剂。

公开(公告)号：US08465576B2

公开(公告)日：2013-06-18

申请号：US12565656

申请日：2009-09-23

申请人： Francesco Della Valle ,  Michela Rampazzo ,  Vanni Canton

发明人： Francesco Della Valle ,  Michela Rampazzo ,  Vanni Canton

IPC分类号： B01D46/00

CPC分类号： A61G13/108 ,  A61G15/10

摘要： A mobile laminar flow hood specifically devised for use in podiatry and a podiatric apparatus to which such hood is associated are described. The hood is adapted to generate a laminar flow of sterile air. In particular, an apparatus comprises a system for the generation and treatment of a laminar air flow in an intervention zone is described, together with means to support the system for the generation and treatment of a laminar air flow. The system has a blowing hood adapted to generate a laminar flow of sterile air towards the intervention zone, and a suction hood adapted to suck the laminar flow of sterile air from the intervention zone.

摘要翻译： 描述了专门设计用于足弓的移动层流罩和与其相关联的足底器具。 罩适于产生无菌空气的层流。 特别地，描述了一种装置，其包括用于产生和处理介入区中的层流空气流的系统，以及用于支撑用于产生和处理层流空气流的系统的装置。 该系统具有适于产生朝向介入区域的无菌空气层流的吹风罩，以及适于从干涉区域抽吸无菌空气的层流的抽吸罩。

公开(公告)号：US09801836B2

公开(公告)日：2017-10-31

申请号：US14711112

申请日：2015-05-13

申请人： Epitech Group S.r.l.

发明人： Francesco Della Valle ,  Maria Federica Della Valle ,  Lorenzo Di Cesare Manelli ,  Carla Ghelardini

IPC分类号： A61K31/164 ,  A61K9/14 ,  A61K31/4468 ,  A61K31/485 ,  A61K45/06

CPC分类号： A61K31/164 ,  A61K9/14 ,  A61K31/4468 ,  A61K31/485 ,  A61K45/06 ,  A61K2300/00

摘要： Described herein are pharmaceutical compositions for human or animal use containing N-palmitoylethanolamide as an analgesic in combination with opioids. In particular, the compositions include palmitoylethanolamide in non-micronized form, in micronized form (PEA-m), in ultra-micronized form (PEAum) or mixtures thereof, for use in humans or animals in combination with an opioid in the treatment of pain conditions, wherein said palmitoylethanolamide is administered separately, sequentially, or in combination with said opioid.

公开(公告)号：US20150057269A1

公开(公告)日：2015-02-26

申请号：US14378185

申请日：2012-02-17

申请人： Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo ,  Vincenzo Di Marzo ,  Salvatore Cuzzocrea

发明人： Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo ,  Vincenzo Di Marzo ,  Salvatore Cuzzocrea

IPC分类号： C07D263/12 ,  A61K31/164 ,  C07D263/14 ,  C07D263/32 ,  A61K31/535 ,  C07D277/10 ,  A61K31/426 ,  A61K31/421 ,  C07D265/06

CPC分类号： C07D263/12 ,  A61K31/164 ,  A61K31/421 ,  A61K31/426 ,  A61K31/535 ,  A61K45/06 ,  C07D263/10 ,  C07D263/14 ,  C07D263/32 ,  C07D265/06 ,  C07D277/10 ,  A61K2300/00

摘要： The present invention regards compositions and methods for the modulation of amidases capable of hydrolysing N-acylethanolamines useable in the therapy of inflammatory diseases. In particular, the present invention regards a compound of general formula (I): enantiomers, diastereoisomers, racemes and mixtures, polymorphs, salts, solvates thereof, wherein: (a) R is a linear alkyl radical having 13 to 19 carbon atoms or alkenyl radical having 13 to 19 carbon atoms carrying a double bond; (b) X is 0 or S; (c) Y is a 2 or 3 carbon atom alkylene residue, optionally substituted with one or two groups equal or different from each other and selected from among the group consisting of: —CH3, —CH2OH, —COOCH3, —COOH. Y may preferably be: —CH2—CH2—, —CH2—CH2—CH2—, CH(CH3)—CH2—, —CH2—CH(CH3)—, —CH2—C(CH3)2—, —CH2—CH(CH2OH)—, —CH2—C((CH2OH)2)—, —CH═CH—, —CH2—CH(COOCH3)—, —CH2—CH(COOH)—, for use as a medicine.

摘要翻译： 本发明涉及调节能够水解可用于治疗炎性疾病的N-酰基乙醇胺的酰胺酶的组合物和方法。 特别地，本发明涉及通式（I）的化合物：对映异构体，非对映异构体，总状体和混合物，多晶型物，盐，溶剂合物，其中：（a）R是具有13至19个碳原子的直链烷基或链烯基 具有13至19个具有双键的碳原子的基团; （b）X为0或S; （c）Y是2或3个碳原子的亚烷基，任选地被一个或两个彼此相同或不同的基团取代，并且选自：-CH 3，-CH 2 OH，-COOCH 3，-COOH。 Y可优选为：-CH 2 -CH 2 - ， - CH 2 -CH 2 -CH 2 - ，CH（CH 3）-CH 2 - ， - CH 2 -CH（CH 3） - ， - CH 2 -C（CH 3）2 - ， - CH 2 -CH （CH 2 OH） - ， - CH 2 -C（（CH 2 OH）2） - ， - CH = CH - ， - CH 2 -CH（COOCH 3） - ， - CH 2 -CH（COOH）

公开(公告)号：US08546352B2

公开(公告)日：2013-10-01

申请号：US13291294

申请日：2011-11-08

申请人： Francesco Della Valle ,  Luciano De Petrocellis ,  Sabatino Maione ,  Vincenzo Di Marzo ,  Maria Federica Della Valle

发明人： Francesco Della Valle ,  Luciano De Petrocellis ,  Sabatino Maione ,  Vincenzo Di Marzo ,  Maria Federica Della Valle

IPC分类号： A61K31/165

CPC分类号： A61K31/165 ,  A61K9/0014 ,  A61K9/0031 ,  A61K9/0034 ,  A61K9/0048 ,  A61K9/006 ,  A61K9/0095 ,  A61K9/06 ,  A61K9/7038 ,  A61K31/07 ,  A61K31/194 ,  A61K31/728 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to topical preparations containing N-palmitoyl-vanillamide having hyperalgesic activity. In particular, the invention relates to N-palmitoyl-vanillamide for use in the treatment of pathologies selected from: post-herpetic neuralgia, neuralgia of trigeminus, occipital neuralgia, dental neuralgia, glottopharyngeal neuralgia, uremic neuralgia, diabetic neuralgia, headache of different origin, neuropathic itch, neurogenic itch, uremic itch, vulvodinia, vulvar vestibulitis, ano-rectal pain and itch, balano-preputial pain and itch, painful urogenital disorders of dogs and cats, psoriasis-associated pruritus and pain, itching skin diseases (e.g. atopic dermatitis) in the human and veterinary field, muscular pain, pain of the tendon, osteoarthritis associated pain in humans, dogs and cats; painful eye diseases in the human and veterinary field, inflammatory pathologies of the oral cavity in the human and veterinary field.

摘要翻译： 本发明涉及具有过敏反应活性的N-棕榈酰 - 香草酰胺的局部制剂。 特别地，本发明涉及用于治疗选自以下的病理学的N-棕榈酰基 - 香草酰胺：疱疹后神经痛，三叉神经痛神经痛，枕骨神经痛，牙齿神经痛，咽喉神经痛，尿毒症神经痛，糖尿病性神经痛，不同来源的头痛 ，神经性瘙痒，神经源性瘙痒，尿毒症瘙痒，外阴阴道炎，外阴前庭炎，直肠疼痛和瘙痒，巴拉阴性疼痛和瘙痒，狗和猫的疼痛性泌尿生殖器疾病，牛皮癣相关性瘙痒和疼痛，瘙痒性皮肤病 人类和兽医领域的肌肉炎，肌肉疼痛，肌腱疼痛，人类，狗和猫中的骨关节炎相关疼痛; 人类和兽医领域的痛苦的眼睛疾病，人类和兽医领域的口腔炎症病理。

公开(公告)号：US09522192B2

公开(公告)日：2016-12-20

申请号：US14103463

申请日：2013-12-11

申请人： EPITECH GROUP S.r.l.

发明人： Antonio Calignano ,  Giuseppe D'Agostino ,  Sonia Laneri ,  Rosaria Meli ,  Carmine Ostacolo ,  Roberto Russo ,  Antonia Sacchi ,  Diana Tronino ,  Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo

IPC分类号： A61K31/164 ,  C07C235/08 ,  A61K47/48 ,  C07C231/12 ,  C07C235/20 ,  C08G59/00

CPC分类号： A61K47/48215 ,  A61K31/164 ,  A61K47/60 ,  C07C231/12 ,  C07C235/20 ,  C08G65/332 ,  C08G65/33324 ,  C08L2203/02

摘要： The synthesis of a series of Polyethylene glycol conjugates (esters and carbonates) of PEA and its analogous acylethanolamides, have higher water solubility and good hydrophilic/lipophilic balance, resulting in (i) improved accumulation in tissues (particularly skin and mucosae), (ii) prolonged release, and (iii) increased bioavailability. Improvement of PEA and analogous acylethanolamides levels in the tissues—particularly in the skin and mucosae—and their prolonged release is due to the improved bioavailability of related conjugates. Conjugates are able to extend the time frame in which PEA and analogous acylethanolamides exert their pharmacological effects.

摘要翻译： 一系列聚乙二醇共轭物（酯和碳酸酯）的一系列PEA及其类似的酰基乙醇酰胺的合成具有较高的水溶性和良好的亲水/亲油平衡，导致（i）改善组织（特别是皮肤和粘膜）中的积累，（ii ）延长释放，和（iii）增加的生物利用度。 组织中特别是皮肤和粘膜中PEA和类似的乙酰乙酰胺水平的改善及其延长的释放是由于相关缀合物的生物利用度得到改善。 共轭物能够延长PEA和类似的乙酰乙酰胺发挥其药理作用的时间框架。

公开(公告)号：US20160045529A1

公开(公告)日：2016-02-18

申请号：US14824389

申请日：2015-08-12

申请人： EPITECH GROUP S.R.L.

发明人： Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo ,  Salvatore Cuzzocrea

IPC分类号： A61K31/7068 ,  A61K9/20 ,  A61K9/00 ,  A61K31/16

CPC分类号： A61K31/7068 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/006 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2054 ,  A61K31/05 ,  A61K31/16 ,  A61K31/164 ,  A61K31/352 ,  A61K31/7048 ,  A61K45/06 ,  A61K2300/00

摘要： The described herein is a pharmaceutical composition for use in humans or animals containing N-palmitoylethanolamide and Cytidinediphosphocholine for the treatment of pathologies of the Central Nervous System of a traumatic, vascular, degenerative nature associated with neurodegeneration. The pharmaceutical composition containing palmitoylethanolamide (PEA) and Cytidinediphosphocholine (CDP-Choline or Citicoline), possibly with the addition of an antioxidant compound such as for example a polyphenol, alpha-lipoic acid or L-acetylcysteine.

摘要翻译： 本文描述的是用于人或动物的药物组合物，其含有N-棕榈酰乙醇酰胺和Cytidinediphosphocholine用于治疗与神经变性相关的创伤，血管，退行性质的中枢神经系统的病理学。 含有棕榈酰乙醇酰胺（PEA）和Cytidinediphosphocholine（CDP-Choline或Citicoline）的药物组合物，可能加入抗氧化剂化合物，例如多酚，α-硫辛酸或L-乙酰半胱氨酸。

公开(公告)号：US20160008301A1

公开(公告)日：2016-01-14

申请号：US14793165

申请日：2015-07-07

申请人： Epitech Group S.r.l.

发明人： Maria Federica DELLA VALLE ,  Francesco DELLA VALLE ,  Vincenzo DI MARZO ,  Stefania PETROSINO ,  Barbara COSTA ,  Gabriele MARCOLONGO ,  Daniele GRASSI

IPC分类号： A61K31/16 ,  A61K36/062 ,  A61K31/201 ,  A61K36/28 ,  A61K31/421 ,  A61K31/728

CPC分类号： A61K31/16 ,  A61K31/164 ,  A61K31/201 ,  A61K31/421 ,  A61K31/728 ,  A61K36/062 ,  A61K36/28 ,  A61K45/06

摘要： The described herein is the use of Adelmidrol in the treatment of epithelial dysfunctions. In particular, described herein is Adelmidrol for use in the treatment of epithelial tissue dysfunctions in a human being or animal, wherein said Adelmidrol causes an increase of the endogenous levels of Palmitoylethanolamide without inhibiting the activity of the Palmitoylethanolamide-degrading FAAH and NAAA enzymes.

摘要翻译： 本文描述的是使用Adelmidrol治疗上皮功能障碍。 特别地，本文描述了Adelmidrol用于治疗人或动物中的上皮组织功能障碍，其中所述Adelmidrol引起棕榈酰乙醇酰胺的内源水平的增加，而不抑制棕榈酰乙酰胺降解FAAH和NAAA酶的活性。

公开(公告)号：US09668986B2

公开(公告)日：2017-06-06

申请号：US14635278

申请日：2015-03-02

申请人： EPITECH GROUP S.R.I.

发明人： Francesco Della Valle ,  Sebastiano Mangiafico ,  Maria Federica Della Valle

IPC分类号： A61K31/133 ,  A61K31/728 ,  A61K47/48 ,  C08G83/00 ,  A61K9/00 ,  A61K31/164

CPC分类号： A61K31/133 ,  A61K9/0048 ,  A61K31/164 ,  A61K31/728 ,  A61K47/6951 ,  C08G83/007

摘要： It is the object of the present invention a composition containing an N-acyl-ethanolamine in a solubilized form, particularly a solution for ophthalmic, intra-articular or intravesical use.Particularly, the present invention relates to a water-soluble composition comprising one or more N-acylethanolamines (NAE) in the form of an inclusion complex in methyl-beta-cyclodextrin (MβCD).

公开(公告)号：US09399031B2

公开(公告)日：2016-07-26

申请号：US14323673

申请日：2014-07-03

申请人： Epitech Group S.r.l.

发明人： Francesco Della Valle ,  Maria Federica Della Valle ,  Gabriele Marcolongo ,  Salvatore Cuzzocrea

IPC分类号： A61K31/357 ,  A61K31/164 ,  A61K45/06 ,  A61K36/28 ,  A61K9/00

CPC分类号： A61K31/357 ,  A61K9/00 ,  A61K9/1623 ,  A61K9/2054 ,  A61K9/4858 ,  A61K31/164 ,  A61K36/28 ,  A61K45/06 ,  A61K2300/00

摘要： A therapy for renal diseases characterized by alterations of the kidney function, such as Chronic Kidney Disease (CKD), acute and chronic renal impairment, and renal diseases that develop in diabetic patients or in patients who underwent an anticancer chemotherapic treatment with a platinum derivative. The invention is a combination of compounds selected from mono- or diamide of a C12-C20 monocarboxylic acid, saturated or monounsaturated, or a C4-C14 dicarboxylic acid, saturated or monounsaturated, with an aminoalkanol, and compounds selected from Silymarin, derivatives thereof or conjugates or complexes thereof, for use in the treatment of renal diseases. The mono- or diamide of a C12-C20 monocarboxylic acid, saturated or monounsaturated, or of a C4-C14 dicarboxylic acid, saturated or monounsaturated, with an aminoalkanol and said Silymarin, derivatives thereof or conjugates or complexes thereof are formulated for a separate, sequential, concomitant administration or in admixture, also in a co-micronized or co-ultra-micronized form.

摘要翻译： 以肾功能改变为特征的肾脏疾病的治疗方法，如慢性肾脏疾病（CKD），急性和慢性肾损害以及在糖尿病患者或接受铂衍生物的抗癌化学疗法治疗的患者中发生的肾脏疾病。 本发明是选自饱和或单不饱和的C 12 -C 20单羧酸的一酰胺或二酰胺或与氨基链烷醇饱和或单不饱和的C 4 -C 14二羧酸的化合物，以及选自水飞蓟马，其衍生物或 缀合物或其复合物，用于治疗肾脏疾病。 饱和或不饱和的饱和或单不饱和的C 12 -C 20二羧酸与氨基链烷醇和所述水飞蓟素，其衍生物或其缀合物或配合物的单酰胺或二酰胺被配制成单独的， 顺序的，伴随的施用或混合，也以共微粉化或共超微粉化形式。