公开(公告)号：US11098054B2

公开(公告)日：2021-08-24

申请号：US16628768

申请日：2018-07-05

Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services ,  Fundacio Institut Catala D'Investigacio Quimica ,  University of Delaware ,  University of Leeds ,  Universitat Rovira I Virgili

Inventor： John A. Beutler ,  Antonio Echavarren ,  William Chain ,  David Beech ,  Zhenhua Wu ,  Jean-Simon Suppo ,  Fernando Bravo ,  Hussein Rubaiy

IPC: C07D493/08 ,  A61P35/00 ,  C07D495/08 ,  C07D471/08

Abstract: Disclosed is a compound of formula (I) in which a, R1-R5 and X1 are as described herein. Also disclosed are a pharmaceutical composition containing the compound and a method of using the compound for treating cancer, such as renal cancer.

公开(公告)号：US10591493B2

公开(公告)日：2020-03-17

申请号：US15543151

申请日：2015-07-28

Applicant: FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA (ICIQ) ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ,  UNIVERSITAT ROVIRA I VIRGILI

Inventor： Louis Adriaenssens ,  Pau Ballester ,  Francisco Javier Andrade ,  Pascal Blondeau ,  Francesc Xavier Rius ,  Tomas De Aquino Guinovart Pavon ,  Daniel Hernandez Alonso

IPC: G01N33/00 ,  G01N33/70 ,  C07D403/14 ,  C07D487/22 ,  B01J39/16 ,  C07D491/22 ,  C07F9/6571 ,  C08J5/22 ,  C08K5/32 ,  C08K5/5373 ,  C08K5/55 ,  G01N27/40

Abstract: Compounds are of the formula (Ia), (Ib), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3 C20)alkynyl; (C1-C6)alkyl-O—; (C3-C20)cycloalkyl; (C1 C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted; R2 and R2′ are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O—; (C1-C6)haloalkyl; halogen; cyano; and nitro; Z1 to Z4 are diradicals of formula (III) wherein A1 and A2 are O— or NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1-C20)alkyl; and G is (C1-C6)alkyl; —P(═S)R5-; —P(═O)R4; —P(═O)(OR4)-; —P(═O)(NR6R7)-; —S(═O)2-; S(═O)—; or —C(═O)—; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8.

公开(公告)号：US09676795B2

公开(公告)日：2017-06-13

申请号：US14000116

申请日：2012-02-17

Applicant: Vladimir Grushin ,  Alessandro Zanardi

Inventor： Vladimir Grushin ,  Alessandro Zanardi

IPC: C07F1/08 ,  C07B39/00 ,  C07C17/32 ,  C07C201/12 ,  C07F1/00 ,  C07C41/30 ,  C07C45/45 ,  C07C45/68

CPC classification number: C07F1/08 ,  C07B39/00 ,  C07C17/32 ,  C07C41/30 ,  C07C45/455 ,  C07C45/68 ,  C07C201/12 ,  C07F1/005 ,  C07C22/08 ,  C07C205/11 ,  C07C43/225 ,  C07C49/80

Abstract: Process to obtain a trifluoromethylating composition which comprises the reaction between a copper (I) source and a base in the presence of a solvent and between the resulting cuprating reagent with fluoroform.

公开(公告)号：US10604469B2

公开(公告)日：2020-03-31

申请号：US16320691

申请日：2017-01-13

Applicant: Fundacio Institut Catala D'Investigacio Quimica ,  Universitat Rovira I Virgili

Inventor： Antonio M. Echavarren ,  Ruth Dorel ,  Paul McGonigal

IPC: C07C43/166 ,  C07D333/16 ,  C07D333/56 ,  C07F7/08 ,  C07C41/18 ,  C07C25/22 ,  C07C47/546 ,  C07C49/84 ,  C07C43/215 ,  C07C43/176 ,  C07C17/361 ,  C07C45/68 ,  C07C41/30 ,  C07C45/64 ,  C07C45/65 ,  C07C47/575 ,  C07C43/21 ,  C07C13/66 ,  C07C1/20 ,  C07C49/792 ,  C07C13/62 ,  C07D333/50 ,  C07C15/38

Abstract: The present invention relates to a process for preparing a partially hydrogenated polyacene, and a novel intermediate used in such process; also the present invention relates to a process for preparing the corresponding conjugated polyacenes.

公开(公告)号：US20170370948A1

公开(公告)日：2017-12-28

申请号：US15543151

申请日：2015-07-28

Applicant: FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA (ICIQ) ,  INSTITUCIO CATALANA DE RECERCA I ESTUDIS AVANCATS ,  UNIVERSITAT ROVIRA I VIRGILI

Inventor： Louis ADRIAENSSENS ,  Pau BALLESTER ,  Francisco Javier ANDRADE ,  Pascal BLONDEAU ,  Francesc Xavier RIUS ,  Tomas De Aquino GUINOVART PAVON ,  Daniel HERNANDEZ ALONSO

IPC: G01N33/70 ,  C08K5/55 ,  C08K5/5373 ,  C07D491/22 ,  B01J39/16 ,  C08J5/22 ,  C07F9/6571 ,  G01N27/40 ,  C08K5/32

CPC classification number: G01N33/70 ,  B01J39/16 ,  C07D403/14 ,  C07D487/22 ,  C07D491/22 ,  C07F9/657181 ,  C08J5/22 ,  C08J2327/06 ,  C08K5/32 ,  C08K5/5373 ,  C08K5/55 ,  G01N27/40

Abstract: Compounds are of the formula (Ia), (Ib), (Ic), or are stereoisomers thereof, wherein: R1 is hydrogen, (C1-C20)alkyl; (C3-C20)alkenyl; (C3 C20)alkynyl; (C1-C6)alkyl-O—; (C3-C20)cycloalkyl; (C1 C20)haloalkyl; (C6-C20)aryl optionally substituted; (C6-C20)heteroaryl optionally substituted; R2 and R2′ are hydrogen; (C1-C20)alkyl; (C1-C6)alkyl-O—; (C1-C6)haloalkyl; halogen;cyano; and nitro; Z1 to Z4 are diradicals of formula (III) wherein Al and A2 are O—or —NR3-, wherein R3 is selected from the group consisting of hydrogen and (C1-C20)alkyl; and G is (C1-C6)alkyl; —P(═S)R5-; —P(═O)R4; P(═O)(OR4)-; —P(═O)(NR6R7)-; —S(=0)2-; S(═O)—; or —C(═O)—; and Y1 to Y4 are (C1-C8)alkyl; (C3-C7)cycloalkyl; (C6-C20)aryl optionally substituted; or (C6-C20)heteroaryl optionally substituted; and FG1 and FG2 are H, OH, or NHR8.