摘要:
The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要:
Described herein are compositions and methods of treating and/or preventing inner ear conditions by administering to a patient in need thereof a modulator of a metabotropic glutamate receptor.
摘要:
A decorrelation method for improving feedback cancellation utilizes a small frequency shifting ratio, on the order of 0.3 percent. Frequency shifting is applied only to the high frequency portion of the signal, which is shifted alternately upward and downward.
摘要:
The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof.
摘要:
Disclosed herein is a composition and a method for the treatment of otitis media and paranasal sinusitis using human defensins, lysozyme and/or lactoferrin as a new class of non-antibiotic antimicrobials. From studies of otitis media and paranasal sinusitis, it was observed that certain innate immune modulators were important in the bodies response to the infection. Therefore, these innate immune modulators, lysozyme, lactoferrin, and defensins were tested for use as a non-antibiotic treatment for infection, particularly infections such as otitis media and sinusitis.
摘要:
An improved method for adaptively cancelling acoustic feedback in hearing aids and other audio amplification devices. Feedback cancellation is limited to a frequency band that encompasses all unstable frequencies. By limiting the bandwidth of the feedback cancellation signal, the distortion due to the adaptive filter is minimized and limited only to the unstable feedback regions. A relatively simple signal processing algorithm is used to produce highly effective results with minimal signal distortion.
摘要:
A pressure regulating ear plug for regulating the rate of change of pressure inside an ear to minimize the pressure differential between the middle ear and a volume of the external ear cavity adjacent the ear drum is made of an ear plug adapted to fit tightly within the external ear cavity with no or minimal air leakage, and disposed within the ear plug is a pressure regulator with a slow leak rate. The pressure regulator is preferably made of a porous ceramic material.
摘要:
A low-cost, multichannel cochlear stimulation system utilizes a passive, non-hermetically sealed, implantable receiver/electrode array and an external wearable processor. At one end of the receiver/electrode array, positioned subcutaneously near the surface of skin above the ear, multiple receiving coils are arranged in an appropriate pattern. At the other end, which is adapted for insertion into the spiral-shaped cochlea, electrodes are spaced apart along the spiral. Each electrode is electrically connected to a respective receiving coil in a monopolar or bipolar fashion. The wearable processor senses audible sounds, converts the sensed sounds to corresponding electrical signals, and divides the electrical signals into multiple frequency bands or channels. A continuous interleaved sampling (CIS) speech processing strategy applies the processed signals of each channel to each of multiple external coils, one coil for each channel, as a series of narrow, rapid, biphasic current pulses. The external coils are aligned, using a suitable headpiece, with corresponding coils of the receiver/electrode array. The narrow CIS pulses contain sufficiently high frequency components to inductively couple the biphasic current pulses directly to the aligned implanted coils without having to modulate a high frequency carrier signal with the biphasic pulses. The induced voltage at the implanted coils causes the biphasic current pulse to appear at a respective electrode of the implanted electrode array, thereby providing electrical stimulation at the cochlea as a function of sensed audible sounds.
摘要:
A procedure for diagnosing cochlear hydrops is based, in part, on an analysis of the patient's auditory brainstem response (ABR) to stimuli. The patient's ABR to a broadband click stimulus is recorded. A plurality of masked ABR's are also recorded, wherein the stimulus is masked by high-pass noise with a plurality of high-pass cut-off frequencies. The latency difference between the wave V component in the unmasked click alone response and the undermasked wave V component of a low cut-off frequency high-pass response is then calculated. If an undermasked component is not present, the normal wave V component is used. The measured latency difference is combined with another measure, such as the wave V amplitude ratio. A distribution of the combined measure is then plotted for the population and a threshold established for diagnosing cochlear hydrops. Alternatively, the joint distribution of the individual measures may be used in situations where the individual measures are known to be independent.
摘要:
In a diagnostic system wherein a patient's auditory brainstem response (ABR) to each of a plurality of auditory stimuli is recorded and wherein a plurality of derived-band ABRs representing cochlear responses in a plurality of respective frequency bands are constructed, the derived-band ABRs are temporarily aligned based on observable peaks in integrated, detrended derived-band waveforms.