公开(公告)号：US5869268A

公开(公告)日：1999-02-09

申请号：US815953

申请日：1997-03-13

申请人： Toshio Kudo ,  Shuichi Hiyamuta ,  Toshiyuki Tanedani ,  Akihiko Kadota

发明人： Toshio Kudo ,  Shuichi Hiyamuta ,  Toshiyuki Tanedani ,  Akihiko Kadota

IPC分类号： A01K67/027 ,  A61K38/00 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30 ,  C12N5/08 ,  C12N5/28 ,  C12N15/85 ,  C12P21/08 ,  G01N33/574

CPC分类号： A01K67/0271 ,  C07K16/00 ,  C07K16/18 ,  C07K16/30 ,  C12N15/8509 ,  A01K2217/05 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/0381 ,  A61K38/00 ,  C07K2317/21

摘要： A method for producing a human lymphocyte producing an antibody specific to a desired antigen, a method for producing a monoclonal antibody, as well as monoclonal antibodies produced by the method, are described. The present invention provides a method for producing a human lymphocyte producing an antibody comprising, in the order mentioned, the steps of: transplanting human lymphocytes into an immunodeficient animal so that the human lymphocytes take in the animal body; immunizing the animal with a desired antigen so as to generate human lymphocytes producing an antibody specific to the antigen; and recovering the human lymphocytes producing the antibody from the animal. The present invention also provides a method for producing a monoclonal antibody comprising, in the order mentioned, the steps of: immortalizing the human lymphocytes producing the antibody which were obtained by the above-mentioned method of the present invention; cloning the obtained immortalized human-derived lymphocytes producing the antibody; and recovering a monoclonal antibody specific to the desired antigen from the cloned immortalized human-derived lymphocytes.

摘要翻译： 对生产对所需抗原特异性抗体的人淋巴细胞的制造方法，单克隆抗体的制造方法以及由该方法制造的单克隆抗体进行说明。 本发明提供了产生抗体的人淋巴细胞的制备方法，其特征在于，按照以下顺序，将人淋巴细胞移植到免疫缺陷型动物中，使人体淋巴细胞摄入动物体内; 用所需抗原免疫动物，以产生产生抗原特异性抗体的人淋巴细胞; 以及从动物中回收产生抗体的人淋巴细胞。 本发明还提供一种单克隆抗体的制备方法，其特征在于，按照上述顺序，通过上述本发明方法获得的产生抗体的人淋巴细胞的永生化步骤; 克隆获得的产生抗体的永生化的人源性淋巴细胞; 并从克隆的永生化人源性淋巴细胞中回收对所需抗原特异性的单克隆抗体。

公开(公告)号：US5344900A

公开(公告)日：1994-09-06

申请号：US56587

申请日：1993-04-30

申请人： Hiroshi Maezawa ,  Junichi Matsumoto ,  Hideki Aiura ,  Satoshi Asahi

发明人： Hiroshi Maezawa ,  Junichi Matsumoto ,  Hideki Aiura ,  Satoshi Asahi

IPC分类号： C08F4/602 ,  C08F4/60 ,  C08F4/6192 ,  C08F4/80 ,  C08F32/00 ,  C08F32/08 ,  C08G61/08 ,  C08F4/42 ,  C08F132/00

CPC分类号： C08G61/08 ,  Y10S526/943

摘要： A process for producing a norbornene polymer consisting essentially of a repeating unit of the formula (I) ##STR1## wherein R.sup.1 to R.sup.12 are the same or different and are hydrogen, C.sub.1 -C.sub.20 hydrocarbon, or a group having a halogen, oxygen or nitrogen, R.sup.5 and R.sup.7 may combine to form a ring, and n is an integer of 0 or more; and having a weight average molecular weight as determined by GPC of 1.times.10.sup.5 to 1.times.10.sup.7. The process comprises polymerizing a norbornene monomer of the formula (II) ##STR2## wherein R.sup.1 to R.sup.12 are the same or different and are independently hydrogen, C.sub.1 -C.sub.20 hydrocarbon, or a substituent containing a halogen atom, an oxygen atom or a nitrogen atom; R.sup.5 and R.sup.7 may combine together to form a ring; and n is an integer of 0 or more, in the presence of a catalyst containing a transition metal compound component containing a transition metal belonging to Group VB, VIB, VIIB or VIII of the Periodic Table, and an aluminoxane components.

摘要翻译： 一种制备降冰片烯聚合物的方法，该降冰片烯聚合物主要由式（I）的重复单元组成，其中R 1至R 12相同或不同，为氢，C 1 -C 20烃或具有卤素的基团， 氧或氮，R5和R7可以结合形成环，n是0以上的整数; 并且通过GPC测定的重均分子量为1×10 5至1×10 7。 该方法包括使式（II）的降冰片烯单体（II）聚合，其中R 1至R 12相同或不同，并且独立地为氢，C 1 -C 20烃或含有卤素原子，氧原子或 氮原子; R5和R7可以结合在一起形成环; 在含有含有属于元素周期表第VB族，VIB族，VIIB或VIII族的过渡金属的过渡金属化合物组分的催化剂和铝氧烷组分的存在下，n为0以上的整数。

公开(公告)号：US5344809A

公开(公告)日：1994-09-06

申请号：US70550

申请日：1993-06-01

申请人： Toshihiro Hirata ,  Shin-ichiro Ogawa

发明人： Toshihiro Hirata ,  Shin-ichiro Ogawa

IPC分类号： A01N47/36 ,  A01N43/68

CPC分类号： A01N43/68

摘要： A herbicidal composition comprising, as active ingredients, a triazine compound of the formula (I): ##STR1## wherein Z is oxygen, sulfur or ##STR2## X.sup.2 is methyl or fluorine, n is 0 to 2,R.sup.1 is hydrogen or methyl, andX.sup.1 is fluorine or chlorine,and a sulfonylurea herbicide of the formula (II): ##STR3## wherein the ratio of the triazine compound to the sulfonylurea herbicide is 100/1 to 1/10 by weight. The herbicidal composition provides a synergistic herbicidal effect against a wide spectrum of weeds, without causing crop injury.

摘要翻译： 作为活性成分的包含式（I）的三嗪化合物的除草组合物：X2是甲基或氟，n是0-2，R1是氢或甲基，X1是氟或氯，磺酰脲 式（II）的除草剂：其中三嗪化合物与磺酰脲除草剂的比例为100/1至1/10（重量比）。 除草组合物对广泛的杂草提供协同的除草效果，而不引起作物损伤。

公开(公告)号：US5312608A

公开(公告)日：1994-05-17

申请号：US58425

申请日：1993-05-07

申请人： Toshiaki Hayasaka ,  Takuma Kimura

发明人： Toshiaki Hayasaka ,  Takuma Kimura

IPC分类号： B01D53/94 ,  B01J29/87 ,  B01D53/34 ,  B01J8/02

CPC分类号： B01D53/945 ,  B01J29/87 ,  Y02C20/10 ,  Y02T10/22

摘要： The catalyst for purifying an exhaust gas has at least gallium and a zeolite and an exhaust gas purifying method using the catalyst. Nitrogen oxides in the exhaust gas are reduced and eliminated by the catalyst in an oxidative atmosphere at a reaction temperature of 200.degree. to 800.degree. C. and under the presence of a hydrocarbon at the total THC concentration/NO.sub.x concentration of from 0.5 to 50.

摘要翻译： 用于净化废气的催化剂至少具有镓和沸石以及使用该催化剂的废气净化方法。 废气中的氮氧化物在氧化气氛中在200-800℃的反应温度和在总氢氧化钠浓度/ NOx浓度为0.5至50℃的烃存在下被催化剂还原和消除。

公开(公告)号：US5290754A

公开(公告)日：1994-03-01

申请号：US582835

申请日：1990-10-05

申请人： Masahiro Nishii ,  Izumi Kobayashi ,  Masatoshi Uemura ,  Tetsuo Takematsu

发明人： Masahiro Nishii ,  Izumi Kobayashi ,  Masatoshi Uemura ,  Tetsuo Takematsu

IPC分类号： C07D405/12 ,  A01N43/68 ,  C07D251/18 ,  C07D407/12 ,  C07D409/12

CPC分类号： C07D405/12 ,  A01N43/68 ,  C07D251/18 ,  C07D409/12

摘要： The present invention relates to a novel triazine derivative represented by the general formula ##STR1## in the formula, A denotes ##STR2## (in which Y.sup.1 denotes a hydrogen atom or a methyl group and Z denotes an oxygen atom or a sulfur atom), ##STR3## (in which Y.sup.2 and Y.sup.3, which can be of the same kind or different kinds, each denote a methyl group or a methoxy group) or ##STR4## (in which Y.sup.4 denotes a methyl group, trifluoromethyl group, methoxy group or fluorine atom and n denotes an integer of 0 ro 2), X.sup.1 denotes a halogen atom and R.sup.1 denotes hydrogen, a methyl group or an ethyl group as well as a herbicide containing the triazine derivative represented by the general formula (I) as an effective ingredient.

摘要翻译： PCT No.PCT / JP90 / 00194 Sec。 371 1990年10月5日第 102（e）1990年10月5日日期PCT提交1990年2月19日PCT公布。 公开号WO90 / 09378 日本1990年8月23日。本发明涉及式中通式（* CHEMICAL STRUCTURE *）（I）表示的新型三嗪衍生物，A表示（*化学结构*）（其中Y1表示氢原子 或甲基，Z表示氧原子或硫原子），（*化学结构*）（其中Y2和Y3可以相同种类或不同，各自表示甲基或甲氧基） 或（*化学结构*）（其中Y4表示甲基，三氟甲基，甲氧基或氟原子，n表示0〜2的整数），X1表示卤素原子，R1表示氢，甲基或 乙基以及含有通式（I）表示的三嗪衍生物作为有效成分的除草剂。

公开(公告)号：US5272037A

公开(公告)日：1993-12-21

申请号：US726807

申请日：1991-07-08

申请人： Junji Ohtani ,  Junji Machida ,  Kazuo Ota ,  Satoshi Asahi ,  Hiroshi Hayashi ,  Kouichi Matono

发明人： Junji Ohtani ,  Junji Machida ,  Kazuo Ota ,  Satoshi Asahi ,  Hiroshi Hayashi ,  Kouichi Matono

IPC分类号： G03G9/113 ,  G03G9/00 ,  B32B5/16 ,  G03G5/00

CPC分类号： G03G9/1139 ,  G03G9/1131 ,  G03G9/1133 ,  Y10T428/2998

摘要： The present invention provides a polyolefinic resin-coated carrier having a rough surface and containing a core material in a quantity of 90 or more % by weight. Said resin-coated layer may contain fine particles having a charge-controlling function and/or electrically conductive fine particles as additives.

摘要翻译： 本发明提供一种具有粗糙表面并含有90重量％以上的芯材的聚烯烃树脂涂布载体。 所述树脂涂层可以含有具有电荷控制功能的微粒和/或导电细颗粒作为添加剂。

公开(公告)号：US5252398A

公开(公告)日：1993-10-12

申请号：US639540

申请日：1991-01-10

申请人： Junji Ohtani ,  Yoshihisa Terasaka ,  Junji Machida ,  Satoshi Asahi ,  Hiroshi Hayashi ,  Kouichi Matono

发明人： Junji Ohtani ,  Yoshihisa Terasaka ,  Junji Machida ,  Satoshi Asahi ,  Hiroshi Hayashi ,  Kouichi Matono

IPC分类号： G03G9/09 ,  G03G9/097 ,  G03G9/113 ,  B32B27/14 ,  G03G9/00

CPC分类号： G03G9/1133 ,  G03G9/1131 ,  Y10T428/2991 ,  Y10T428/2998

摘要： The present invention provides a carrier of a two component developer for developing electrostatic latent images comprising;a carrier core material comprising a magnetic particle,an irregular surface-coating layer formed by coating the carrier core material with polyolefinic resin, followed by heat treatment.

公开(公告)号：US5238828A

公开(公告)日：1993-08-24

申请号：US760824

申请日：1991-09-17

申请人： Nobuo Murakami

发明人： Nobuo Murakami

IPC分类号： C12P7/40 ,  C12P41/00

CPC分类号： C12P7/40 ,  C12P41/006

摘要： An efficient microbiological or biochemical method is proposed for the preparation of an optically active 2-substituted carboxylic acid, e.g., 2-chloropropionic acid, 2-methyl butyric acid and the like, from the corresponding 2-substituted nitrile compound, e.g., 2-chloropropionitrile, 2-methyl butyronitrile and the like, in the form of a racemic body as the starting material The method comprises bringing the starting nitrile compound into contact with a microorganism, such as Pseudomonas sp. MY-1 (FERM BP-2541), Fusarium sp. MY-2 (FERM BP-2542) and the like, capable of converting the nitrile compound into the carboxylic acid in a buffered aqueous medium in which the microbial cells of the microorganism are suspended.

摘要翻译： 提出了从相应的2-取代腈化合物制备光学活性2-取代羧酸（例如2-氯丙酸，2-甲基丁酸等）的有效的微生物或生物化学方法，例如2- 氯丙腈，2-甲基丁腈等以外消旋体的形式作为起始原料。该方法包括使起始腈化合物与微生物例如假单胞菌属（Pseudomonas sp。）接触。 MY-1（FERM BP-2541），Fusarium sp。 MY-2（FERM BP-2542）等，能够在悬浮有微生物的微生物细胞的缓冲水性介质中将腈化合物转化成羧酸。

公开(公告)号：US5234893A

公开(公告)日：1993-08-10

申请号：US734215

申请日：1991-07-22

申请人： Toshihiro Hirata ,  Izumi Kobayashi ,  Nobuyuki Kikkawa ,  Tetsuo Takematsu

发明人： Toshihiro Hirata ,  Izumi Kobayashi ,  Nobuyuki Kikkawa ,  Tetsuo Takematsu

IPC分类号： A01N47/36 ,  A01N43/68

CPC分类号： A01N43/68

摘要： Herbicidal compositions comprising as active ingredient a triazine derivative represented by general formula [I]: ##STR1## and suIfonylurea type herbicides represented by general formula [II]: ##STR2## By synergistic effects of active ingredients, the herbicidal compositions show a high herbicidal effect at low dosage and have such a wide range of herbicidal spectrum that the compositions exhibit their high herbicidal effect not only against broad-leaved weeds but also against Gramineae weeds, etc. The compositions have flexibility of treatment to exhibit effectiveness as compared to known herbicides for field crops and crops are free from injury.

公开(公告)号：US5175345A

公开(公告)日：1992-12-29

申请号：US854734

申请日：1992-03-23

申请人： Izumi Terada ,  Masahiro Nishii ,  Kazufumi Nakamura

发明人： Izumi Terada ,  Masahiro Nishii ,  Kazufumi Nakamura

IPC分类号： C07C51/363 ,  C07C67/307

CPC分类号： C07C51/363 ,  C07C67/307

摘要： A 2-fluoroisobutyric acid ester can be obtained at a high yield in one pot by reacting a 2-hydroxyisobutyric acid ester with fluorosulfuric acid in the absence or presence of a hydrogen fluoride source, or by reacting a 2-hydroxyisobutyric acid ester with chlorosulfuric acid in the presence of a hydrogen fluoride source.

摘要翻译： 2-氟异丁酸酯可以通过在不存在或存在氟化氢源的情况下使2-羟基异丁酸酯与氟代硫酸反应，或通过使2-羟基异丁酸酯与氯硫酸反应， 在氟化氢源的存在下。