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公开(公告)号：US08362011B2
公开(公告)日：2013-01-29
申请号：US12746635
申请日：2008-12-05
申请人： Miguel Angel Pericas-Brondo , Antoni Torrens-Jover , Félix Cuevas-Cordobes , Susana Yenes-Minguez
发明人： Miguel Angel Pericas-Brondo , Antoni Torrens-Jover , Félix Cuevas-Cordobes , Susana Yenes-Minguez
IPC分类号： C07D498/14 , A61K31/5383
CPC分类号： C07D498/14
摘要： The present invention relates to new tricyclic triazolic compounds having a high affinity for sigma-1 receptor as well as to the process for the preparation thereof, to composition comprising them and to their use as medicaments according to compounds of formula (I), Wherein R1 and R2 are as defined in the description.
摘要翻译： 本发明涉及对σ-1受体具有高亲和力的新型三环三唑化合物及其制备方法，包含它们的组合物及其作为根据式（I）化合物的药物的用途，其中R1 和R2如说明书中所定义。
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2.发明授权Sulfonamide substituted pyrazoline compounds, their preparation and use as CB1 modulators 失效磺酰胺取代的吡唑啉化合物，其制备和用作CB1调节剂公开(公告)号：US08044053B2
公开(公告)日：2011-10-25
申请号：US12445260
申请日：2007-10-10
IPC分类号： A61K31/501 , A61K31/496 , A61K31/497 , A61K31/437 , A61K31/4523 , A61K31/415 , A61K31/4178 , A61K31/4245 , A61K31/426 , A61K31/433 , C07D237/02 , C07D239/02 , C07D241/02 , C07D221/02 , C07D221/00 , C07D401/02 , C07D277/20 , C07D263/30 , C07D271/08 , C07D285/10 , C07D233/54 , C07D231/10
CPC分类号： C07D231/06 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D513/04
摘要： The present invention relates to substituted pyrazoline compounds of general formula (I), methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans and animals.
摘要翻译： 本发明涉及通式（I）的取代吡唑啉化合物，其制备方法，包含这些化合物的药物及其制备用于治疗人和动物的药物的用途。
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3.发明申请SUBSTITUTED TETRAHYDRO-QUINOLINE-SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS 失效取代的四氢喹啉磺酰胺化合物，其制备和用作药物公开(公告)号：US20090030013A1
公开(公告)日：2009-01-29
申请号：US12175660
申请日：2008-07-18
IPC分类号： A61K31/496 , C07D401/02 , A61P3/00 , A61P25/00
CPC分类号： A61K31/4709 , C07D215/38 , C07D215/58
摘要： The present invention refers to substituted tetrahydro-quinoline-sulfonamide compounds of general formula (I): a method for their preparation, a medicament comprising these compounds and the use of substituted tetrahydro-quinoline-sulfonamide compounds for the preparation of medicaments for 5-HT6 receptor regulation as well as for the treatment of disorders related thereto.
摘要翻译： 本发明涉及通式（I）的取代的四氢 - 喹啉 - 磺酰胺化合物：其制备方法，包含这些化合物的药物以及取代的四氢 - 喹啉 - 磺酰胺化合物用于制备5-HT6的药物 受体调节以及与之相关的疾病的治疗。
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公开(公告)号：US20080280942A1
公开(公告)日：2008-11-13
申请号：US11997136
申请日：2006-07-26
IPC分类号： A61K31/437 , C07D471/14 , A61P3/00 , A61P25/22 , A61P25/28 , A61P25/18
CPC分类号： C07D471/04
摘要： The present invention relates to new tetrahydro-β-carbolin-sulfonamide derivatives of general formula (I), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemates or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or corresponding physiologically acceptable salts or corresponding solvates. These compounds are suitable as pharmacologically active agents in a medicament for the prophylaxis and/or treatment of disorders or diseases related to 5-HT6 receptors. The invention also relates to two different methods for obtaining the mentioned compounds and to pharmaceutical compositions containing them.
摘要翻译： 本发明涉及通式（I）的新的四氢-β-咔啉 - 磺酰胺衍生物，任选地以其立体异构体之一的形式，优选对映异构体或非对映异构体，其外消旋体或其至少两种立体异构体的混合物的形式 ，优选对映异构体或非对映体，以任何混合比例，或相应的生理上可接受的盐或相应的溶剂化物。 这些化合物在用于预防和/或治疗与5-HT 6受体相关的疾病或疾病的药物中适合作为药理学活性剂。 本发明还涉及获得所述化合物和含有它们的药物组合物的两种不同方法。
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公开(公告)号：US07105515B2
公开(公告)日：2006-09-12
申请号：US10293206
申请日：2002-11-13
IPC分类号： A61K31/5375 , A61K31/495 , A61K31/404 , C07D413/06 , C07D209/04
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
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6.发明授权Use of 1-[4-[4-aryl (or heteroaryl)-1-piperazinyl]-butyl)-1H-azole derivatives for the preparation of medicaments intended for the treatment of disorders of gastric secretion 失效1- [4- [4-芳基（或杂芳基）-1-哌嗪基] - 丁基）-1H-吡唑衍生物在制备用于治疗胃分泌紊乱的药物中的用途
公开(公告)号：US5532234A
公开(公告)日：1996-07-02
申请号：US344377
申请日：1994-11-23
IPC分类号： C07D249/08 , A61K31/495 , A61K31/505 , A61P1/04 , C07D207/325 , C07D231/16 , C07D233/68 , C07D403/12 , C07D417/12 , C07D471/04 , A61K31/54 , A61K31/535
CPC分类号： A61K31/505 , A61K31/495 , Y10S514/925
摘要： The present invention relates to the use of 1-{4-[4-aryl(or heteroaryl)-1-piperazinyl]butyl}-1H-azole derivatives and of their physiologically acceptable salts for the manufacture of medicaments intended for the treatment of disorders associated with gastric secretion.
摘要翻译： 本发明涉及1- {4- [4-芳基（或杂芳基）-1-哌嗪基]丁基} -1H-吡唑衍生物及其生理学上可接受的盐在制备用于治疗疾病的药物中的用途 与胃分泌相关。
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![Imidazo[2,1-b]thiazole derivatives, their preparation and use as medicaments](/abs-image/US/2017/04/11/US09617281B2/abs.jpg.150x150.jpg)
公开(公告)号：US09617281B2
公开(公告)日：2017-04-11
申请号：US14412257
申请日：2013-07-04
发明人： María de las Ermitas Alcalde-Pais , José Luís Diaz Fernández , María de les Neus Mesquida-Estevez , Laura Paloma-Romeu
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The present invention relates to new imidazo[2,1-b]thiazole derivatives having a great affinity for sigma receptors, especially sigma-1 receptors, as well as to the process for the preparation thereof, to compositions comprising them, and to their use as medicaments.
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公开(公告)号：US09241927B2
公开(公告)日：2016-01-26
申请号：US13511706
申请日：2010-11-25
IPC分类号： A61K31/4152 , A61K9/16
CPC分类号： A61K31/4152 , A61K9/1623 , A61K9/1652 , A61K9/1694
摘要： The present invention relates to a pharmaceutical composition that comprises a compound of formula (I) as active pharmaceutical ingredient: or a pharmaceutically acceptable salt, isomer, prodrug or solvate thereof; and at least a pharmaceutically acceptable excipient, wherein the active pharmaceutical ingredient is present in an amount of at least 80% of the total dry weight of the composition.
摘要翻译： 本发明涉及包含作为活性药物成分的式（I）化合物或其药学上可接受的盐，异构体，前药或溶剂合物的药物组合物; 和至少一种药学上可接受的赋形剂，其中活性药物成分的存在量为组合物总干重的至少80％。
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公开(公告)号：US08293740B2
公开(公告)日：2012-10-23
申请号：US12703114
申请日：2010-02-09
申请人： Christian Laggner , Maria Rosa Cuberes-Altisent , Joerg Holenz , Juana Maria Berrocal-Romero , Maria Montserrat Contijoch-Llobet
发明人： Christian Laggner , Maria Rosa Cuberes-Altisent , Joerg Holenz , Juana Maria Berrocal-Romero , Maria Montserrat Contijoch-Llobet
IPC分类号： A61K31/5377 , A61K31/4155 , C07D231/22 , C07D413/12
CPC分类号： A61K31/415 , A61K31/4178 , A61K31/437 , A61K31/454 , A61K31/4725 , A61K31/496 , A61K31/5377 , A61K31/541
摘要： The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
摘要翻译： 本发明涉及具有对σ受体的药理学活性的式（I）化合物，这些化合物的制备方法，包含它们的药物组合物及其用于治疗和/或预防其中σ受体 参与。
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公开(公告)号：US07452881B2
公开(公告)日：2008-11-18
申请号：US11707571
申请日：2007-02-16
IPC分类号： A61K31/5375 , A61K31/404 , C07D413/02 , C07D209/04
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
摘要翻译： 本发明涉及具有通式（I）的磺酰胺的新衍生物，以及它们的生理上可接受的盐，其制备方法，它们作为人和/或兽医治疗中的药物的用途，以及含有 他们。
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