公开(公告)号：US20230052697A1

公开(公告)日：2023-02-16

申请号：US17710756

申请日：2022-03-31

申请人： Progenity, Inc.

发明人： Pankaj OBEROI ,  Sharat SINGH ,  Amin MAZLOOM

IPC分类号： G01N33/537 ,  G01N33/68 ,  G01N33/74

摘要： Described herein are methods, compositions, kits, and systems for detecting free and bound PlGF, and using detection of such species to distinguish between pregnant women with or without preeclampsia or related conditions.

公开(公告)号：US20230041197A1

公开(公告)日：2023-02-09

申请号：US17253799

申请日：2019-06-19

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli ,  Kevin David Howe ,  Arana Perera

IPC分类号： A61M31/00 ,  A61K38/19

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immunomodulator.

公开(公告)号：US11363964B2

公开(公告)日：2022-06-21

申请号：US15940407

申请日：2018-03-29

申请人： Progenity Inc.

发明人： Mitchell Lawrence Jones ,  Yi Liu ,  Kate LeeAnn Bechtel ,  Christopher Loren Wahl

IPC分类号： A61B5/06 ,  A61B5/00 ,  A61B5/07 ,  G16H40/67 ,  A61B5/11 ,  A61B10/00

摘要： Ingestible devices are disclosed that provide very high localization accuracy for the devices when present in the GI tract of a body. Related systems and methods are also disclosed.

公开(公告)号：US20220135666A1

公开(公告)日：2022-05-05

申请号：US16769983

申请日：2018-12-13

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli ,  Kevin David Howe ,  Aruna Perera

IPC分类号： C07K16/24 ,  A61K31/4196 ,  A61K31/4245 ,  A61K31/428 ,  A61K31/436 ,  A61K31/519 ,  A61K31/606 ,  A61K38/08 ,  A61K38/13 ,  A61K9/48 ,  C07K16/28 ,  A61K9/19 ,  A61K31/573

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with a S1P modulator.

公开(公告)号：US11241562B2

公开(公告)日：2022-02-08

申请号：US16299537

申请日：2019-03-12

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Russell B. Ford ,  Edward G. Solomon ,  Jeffrey A. Shimizu

IPC分类号： A61M31/00 ,  A61B10/00 ,  A61B10/02 ,  A61B5/00 ,  A61K9/00 ,  A61B1/04 ,  A61B10/04

摘要： Ingestible devices with a relatively large payload volume or sample volume, as well as related components, systems and methods, are disclosed.

公开(公告)号：US20210373001A1

公开(公告)日：2021-12-02

申请号：US17393708

申请日：2021-08-04

申请人： Progenity, Inc.

发明人： Pankaj OBEROI ,  Sharat SINGH ,  Amin MAZLOOM

IPC分类号： G01N33/537 ,  G01N33/68 ,  G01N33/74

摘要： Described herein are methods, compositions, kits, and systems for detecting free and bound PlGF, and using detection of such species to distinguish between pregnant women with or without preeclampsia or related conditions.

公开(公告)号：US20210138213A1

公开(公告)日：2021-05-13

申请号：US16496791

申请日：2018-03-30

申请人： Progenity, Inc.

发明人： Mitchell Lawrence Jones ,  Sharat Singh ,  Christopher Loren Wahl ,  Harry Stylli

IPC分类号： A61M31/00 ,  A61K9/00 ,  A61P1/04 ,  C07K16/24 ,  A61K31/436 ,  A61K9/48 ,  C07K16/28 ,  A61K38/13 ,  C12N15/113

摘要： This disclosure features methods and compositions for treating diseases of the gastrointestinal tract with an immune modulatory agent (e.g., a CD40/CD40L inhibitor).

公开(公告)号：US10588608B2

公开(公告)日：2020-03-17

申请号：US15680430

申请日：2017-08-18

申请人： Progenity Inc.

发明人： Mitchell Lawrence Jones ,  Christopher Loren Wahl ,  Aaron Olafur Laurence Philippsen ,  Nicholas David Allan ,  Mark Sasha Drlik ,  Ryan Paul McGuinness ,  Sharat Singh ,  Robert S. Magyar

IPC分类号： A61B5/00 ,  A61B10/00 ,  B01L3/00 ,  G01N1/40 ,  G01N33/569 ,  A61B5/145 ,  A61B10/02

摘要： Sampling systems that include an absorbent material a preservative, such as an analyte preservative, as well as related materials and methods, are disclosed.

公开(公告)号：US20220282315A1

公开(公告)日：2022-09-08

申请号：US17500422

申请日：2021-10-13

申请人： Progenity, Inc.

发明人： Matthew SEKEDAT ,  Jeffrey BUIS ,  Ronald David BEAUBIEN, JR. ,  Sharat SINGH ,  Jeff PERRY ,  Steven LOCKTON ,  Chandni JAIN ,  Natalie Mae JAMESON-KIESLING

IPC分类号： C12Q1/6837 ,  C12Q1/6853

摘要： Compositions and methods, systems, and kits for detecting and quantifying variations in numbers of molecules, particularly variations in gene dosage, e.g., due to gene duplication, or to variations from the normal euploid complement of chromosomes, e.g., trisomy of one or more chromosomes that are normally found in diploid pairs, without digital sequencing.

公开(公告)号：US20220249814A1

公开(公告)日：2022-08-11

申请号：US17295277

申请日：2019-11-19

申请人： PROGENITY, INC.

发明人： Jeffrey A. Shimizu ,  Mitchell Lawrence Jones ,  Mark Sasha Drlik ,  Iman Niknia ,  Nathan John Muller ,  Tuyen Nguyen ,  Christopher Loren Wahl ,  Edward Mudge ,  Nicholas Mark Salt ,  Nia Eleri Stevens ,  Stuart Robert Abercrombie ,  Christopher Ian Bunce ,  Nelson Quintana

IPC分类号： A61M31/00 ,  A61M11/02

摘要： This disclosure features methods and devices for treating diseases with orally-delivered biotherapeutics.