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公开(公告)号:US20240156584A1
公开(公告)日:2024-05-16
申请号:US18511782
申请日:2023-11-16
申请人: Pulmonx Corporation
发明人: Sri Radhakrishnan , Ryan Olivera
CPC分类号: A61F2/04 , A61M16/209 , A61F2002/043 , A61M2205/04
摘要: Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at higher than normal breathing pressures.
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公开(公告)号:US11931170B2
公开(公告)日:2024-03-19
申请号:US16706474
申请日:2019-12-06
申请人: Pulmonx Corporation
发明人: Ajit Nair , Son Gia , Roger Farhnoltz , Nikolai Aljuri
IPC分类号: A61B5/00 , A61B5/08 , A61B5/085 , A61B5/097 , A61B17/12 , A61F2/04 , A61M16/04 , A61M16/08 , A61M25/00 , A61M25/06
CPC分类号: A61B5/4836 , A61B5/08 , A61B5/085 , A61B5/097 , A61B5/6853 , A61B17/12104 , A61M16/04 , A61M16/0406 , A61M16/0866 , A61M25/0075 , A61M25/0662 , A61F2002/043 , A61M2025/0004 , A61M2025/0681
摘要: Lung conditions are diagnosed and optionally treated using a functional assessment catheter or a functional lung assessment and treatment catheter. A flow restrictive component is initially placed in a bronchus or lung passageway upstream from a diseased lung region. The isolated lung region is then functionally assessed through the catheter, while the flow restrictive component remains in place. If the patient is a good candidate for treatment by occlusive or restrictive treatment techniques, the flow resistive component may be left in place. If the patient is not suitable for such treatment, the flow resistive component may be removed.
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公开(公告)号:US20240032866A1
公开(公告)日:2024-02-01
申请号:US18485150
申请日:2023-10-11
申请人: Pulmonx Corporation
发明人: Lutz FREITAG
CPC分类号: A61B5/6852 , A61B5/08 , B21F45/008 , A61M16/0459 , A61M16/0445 , A61M16/0434 , A61B17/12104 , A61M16/0443 , A61M16/0463 , A61M16/0406 , A61B17/12136 , A61M16/0404 , A61B17/12036 , A61M16/0447 , A61M16/0429 , A61M25/0074 , A61M25/0082 , A61B17/221 , A61M25/00 , A61M2025/0096 , A61M2205/7536 , A61B2017/22068
摘要: Devices systems and methods are disclosed for removing secretions from the lumen of a functional assessment catheter for the lungs. The system comprises a flushing unit configured to deliver a clearing fluid to the lumen of the pulmonary catheter to remove debris, secretions, or moisture from the lumen or sensors.
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公开(公告)号:US11857406B2
公开(公告)日:2024-01-02
申请号:US18055729
申请日:2022-11-15
申请人: Pulmonx Corporation
发明人: Sri Radhakrishnan , Ryan Olivera
CPC分类号: A61F2/04 , A61M16/209 , A61F2002/043 , A61M2205/04
摘要: Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at higher than normal breathing pressures.
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公开(公告)号:US11083556B2
公开(公告)日:2021-08-10
申请号:US16436711
申请日:2019-06-10
申请人: Pulmonx Corporation
发明人: Ryan Olivera , Hoang Nguyen
摘要: Devices, methods, and systems are provided for loading an implantable device into a container. One aspect of the loading system contains a loader element with a loading tunnel that is configured to gradually contract an implantable device into a compressed state of reduced size relative to an expanded state as the implantable device travels through the loading tunnel.
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公开(公告)号:US10758333B2
公开(公告)日:2020-09-01
申请号:US15714868
申请日:2017-09-25
申请人: Pulmonx Corporation
发明人: Sri Radhakrishnan , Ryan Olivera
摘要: Disclosed are methods and devices for regulating fluid flow to and from a region of a patient's lung, such as to achieve a desired fluid flow dynamic to a lung region during respiration and/or to induce collapse in one or more lung regions. Pursuant to an exemplary procedure, an identified region of the lung is targeted for treatment. The targeted lung region is then bronchially isolated to regulate airflow into and/or out of the targeted lung region through one or more bronchial passageways that feed air to the targeted lung region. An exemplary flow control device is configured to block fluid flow in the inspiratory direction and the expiratory direction at normal breathing pressures and allow fluid flow in the expiratory direction at coughing pressures.
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公开(公告)号:US10478125B2
公开(公告)日:2019-11-19
申请号:US14195532
申请日:2014-03-03
申请人: Pulmonx Corporation
发明人: Lutz Freitag
摘要: Devices systems and methods are disclosed for removing secretions from the lumen of a functional assessment catheter for the lungs. The system comprises a flushing unit configured to deliver a clearing fluid to the lumen of the pulmonary catheter to remove debris, secretions, or moisture from the lumen or sensors.
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公开(公告)号:US10413300B2
公开(公告)日:2019-09-17
申请号:US15182453
申请日:2016-06-14
申请人: PulmonX Corporation
发明人: Sri Radhakrishnan , Ryan Olivera
摘要: Devices, methods, and systems are provided for occluding a collateral flow channel between a target lung compartment and an adjacent lung compartment. A video-assisted thoracoscopic device is inserted into a thoracic cavity of a patient and positioned at a fissure between a target lung compartment and an adjacent lung compartment. A collateral flow channel between the target lung compartment and the adjacent lung compartment is then identified using the video-assisted thoracoscopic device and an agent is injected into the collateral flow channel, thereby reducing the collateral flow channel.
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9.
公开(公告)号:US10314992B2
公开(公告)日:2019-06-11
申请号:US14703670
申请日:2015-05-04
申请人: Pulmonx Corporation
发明人: Nikolai Aljuri , Rodney C. Perkins , Ryan Olivera , Hoang Nguyen , Srikanth Radhakrishnan , Niyazi Beyhan
IPC分类号: A61M16/04 , A61B17/12 , A61M16/00 , A61B1/267 , A61B5/00 , A61B5/08 , A61M16/20 , A61M25/10 , A61F2/04
摘要: The volume of a hyperinflated lung compartment is reduced by sealing a distal end of the catheter in an airway feeding the lung compartment. Air passes out of the lung compartment through a passage in the catheter while the patient exhales. A one-way flow element associated with the catheter prevents air from re-entering the lung compartment as the patient inhales. Over time, the pressure of regions surrounding the lung compartment cause it to collapse as the volume of air diminishes. Residual volume reduction effectively results in functional lung volume expansion. Optionally, the lung compartment may be sealed in order to permanently prevent air from re-entering the lung compartment. The invention further discloses a catheter with a transparent occlusion element at its tip that enables examination of the lung passageway through a viewing scope.
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公开(公告)号:US09999701B2
公开(公告)日:2018-06-19
申请号:US15425216
申请日:2017-02-06
申请人: Pulmonx
CPC分类号: A61L24/06 , A61L24/0031 , A61L24/0036 , A61L24/0042 , A61L24/043 , A61L2300/604 , A61L2400/06 , A61M25/10 , A61M2025/1052 , A61M2210/1039 , C08F116/06 , C08F2810/20 , C08J3/075 , C08J9/30 , C08J9/36 , C08J2205/022 , C08J2207/10 , C08J2329/04
摘要: One aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant nucleophilic groups and a crosslinker comprising at least two pendant electrophilic groups. Another aspect of the invention relates to a hydrogel comprising a non-natural polymer comprising a plurality of pendant electrophilic groups and a crosslinker comprising at least two pendant nucleophilic groups. Yet another aspect of the invention relates to a method for reducing lung volume in a patient comprising the step of administering a hydrogel composition as described herein. Further, hydrogels of the invention may be used to achieve pleurodesis, seal brochopleural fistulas, seal an air leak in a lung, achieve hemostasis, tissue sealing (e.g., blood vessels, internal organs), or any combination thereof. In certain embodiments, the compositions and methods described herein are intended for use in the treatment of patients with emphysema.
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