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1.发明公开公开(公告)号：US20240359005A1
公开(公告)日：2024-10-31
申请号：US18649710
申请日：2024-04-29
申请人： Realeve, LLC
CPC分类号： A61N1/327 , A61N1/0526
摘要： An electrical stimulation device for modulating a blood-brain barrier (BBB) of a subject includes at least one electrode configured to delivery electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject, and a control unit in communication with the at least one electrode. The control unit generates a first electrical stimulation signal to the at least one electrode to apply a first electrical stimulation to the subject to stimulate a sphenopalatine ganglion (SPG) of the subject thereby increasing porosity of the BBB from an initial porosity to an increased porosity, and generate, after said first electrical stimulation signal, a second electrical stimulation signal to the at least one electrode to apply a second electrical stimulation to the subject to stimulate the SPG of the subject thereby decreasing porosity of the BBB from the increased porosity to a decreased porosity that is less than the increased porosity.
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公开(公告)号：US11679263B2
公开(公告)日：2023-06-20
申请号：US16229202
申请日：2018-12-21
申请人： Realeve, LLC
发明人： William Hsu , Ian Welsford , Mark Van Kerkwyk , Vimel Ganesan
CPC分类号： A61N1/36075 , A61B5/4809 , A61B5/4836 , A61N1/0546 , A61N1/3614 , A61B2562/0219 , A61B2562/0247
摘要： Methods and systems for improving headache pain by using feedback mechanisms are provided.
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3.发明授权公开(公告)号：US11478641B2
公开(公告)日：2022-10-25
申请号：US16736004
申请日：2020-01-07
申请人： Realeve, LLC
发明人： Tom Luhrs , Alan Cheng , Ryan Powell , Jennifer Teng
摘要： One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.
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公开(公告)号：US20240226562A1
公开(公告)日：2024-07-11
申请号：US18544126
申请日：2023-12-18
申请人： Realeve, LLC
发明人： William Hsu , Anthony Caparso , Thomas Luhrs , Ian G. Welsford , Mark Van Kerkwyk , Vimal Ganesan
CPC分类号： A61N1/36075 , A61N1/0546 , A61N1/372 , A61N1/37217 , A61N1/37518 , A61N1/3787
摘要： One aspect of the present disclosure relates to a system for treating a medical condition in a patient. The system can include a neurostimulator that is in electrical communication with a remote transducer. The neurostimulator can be sized and dimensioned for injection or insertion into a pterygopalatine fossa (PPF) of a patient. The remote transducer, when activated and brought into close proximity to the patient's head, can cause the neurostimulator to deliver an electrical signal to a target neural structure located within the PPF to treat the medical condition.
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公开(公告)号：US20240001123A1
公开(公告)日：2024-01-04
申请号：US18311541
申请日：2023-05-03
申请人： Realeve, LLC
发明人： William Hsu , Ian Welsford , Mark Van Kerkwyk , Vimel Ganesan
CPC分类号： A61N1/36075 , A61B5/4836 , A61N1/0546 , A61B5/4809 , A61N1/3614 , A61B2562/0219 , A61B2562/0247
摘要： Methods and systems for improving headache pain by using feedback mechanisms are provided.
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公开(公告)号：US20240198103A1
公开(公告)日：2024-06-20
申请号：US18591326
申请日：2024-02-29
申请人： Realeve, LLC
发明人： William Hsu , Ian Welsford , Mark Van Kerkwyk , Vimal Ganesan , Bruce Levin
CPC分类号： A61N1/36075 , A61N1/0546 , A61N1/36146 , A61N1/37241 , A61N1/3787 , A61N1/0476 , A61N1/0526 , A61N1/36057 , A61N1/37205
摘要： An implantable neurostimulator includes a lead comprising a plurality of electrodes at a distal end, and an implant body including electronics for controlling operation of the electrodes. An electrical connector establishes an electrical connection between the electronics and the electrodes. The implant body includes a first portion of the electrical connector, and the proximal end of the lead includes a second portion of the electrical connector. The first and second portions of the electrical connector are connectable to establish the electrical connection between the electronics and the electrodes. The lead is configured for initial implantation in the patient and the implant body is configured for subsequent implantation in the patient. The electrical connector is configured so that the connection of the first and second portions can be performed with the implant body and the lead positioned at a surgical site in the patient.
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7.发明申请公开(公告)号：US20230111536A1
公开(公告)日：2023-04-13
申请号：US17933950
申请日：2022-09-21
申请人： Realeve, LLC
发明人： Tom Luhrs , Alan Cheng , Ryan Powell , Jennifer Teng
摘要： One aspect of the present disclosure includes a delivery tool configured to deliver a neurostimulator into a pterygopalatine fossa of a subject. The neurostimulator can include a body connected to an integral stimulation lead having one or more stimulating electrodes. The delivery tool can comprise a handle, an elongated shaft extending from the handle, a hub portion, and a double barrel sheath. The hub portion can be located between the shaft and a spine member that extends axially away from the hub portion. The hub portion can be sized and dimensioned to releasably mate with the neurostimulator. The double barrel sheath can be connected to the spine member. A central lumen can extend through at least a portion of the shaft and the hub portion. The central lumen can be adapted to receive a lead ejector for selective deployment of the stimulation lead from the double barrel sheath.
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