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    Delivery of nucleic acid-like compounds
    2.
    发明授权
    Delivery of nucleic acid-like compounds 有权
    递送核酸样化合物

    公开(公告)号：US08883200B2

    公开(公告)日：2014-11-11

    申请号：US13940116

    申请日：2013-07-11

    申请人： Sutter West Bay Hospital

    发明人： Keelung Hong ,  Wei Wen Zheng ,  Daryl C. Drummond ,  Dmitri B. Kirpotin ,  Mark Eamon Hayes

    IPC分类号： A61K9/127 ,  A61K9/14 ,  A61K31/711 ,  A61K48/00

    CPC分类号： A61K9/1272 ,  A61K9/127 ,  A61K9/1271 ,  A61K31/711 ,  A61K48/0025 ,  A61K48/0041 ,  A61K48/0091

    摘要： Provided herein is a process for preparing a microparticulate complex of a particle-forming component (“PFC”) and a nucleic acid-like component (“NAC”) in a monophasic composition comprising water and a water-miscible organic solvent. Also provided is a microparticulate complex that comprises a particle-forming component complexed to a nucleic acid-like component, and a composition comprising water and the microparticulate complex. Further provided is a method of delivery of a nucleic acid-like component to a cell or to a patient by contacting the cell with or administering to the patient a composition comprising water and the microparticulate complex described herein. Still further, a charge-changing composition represented by the formula A-X—B is provided.

    摘要翻译： 本文提供了在包含水和水混溶性有机溶剂的单相组合物中制备颗粒形成组分（“PFC”）和核酸样组分（“NAC”）的微粒复合物的方法。 还提供了包含与核酸样组分复合的颗粒形成组分的微粒复合物，以及包含水和微粒复合物的组合物。 还提供了通过使细胞与患者接触或给予患者包含水和本文所述的微粒复合物的组合物将核酸样成分递送至细胞或患者的方法。 此外，提供了由式A-X-B表示的电荷变化组合物。

    Anti-PECAM Therapy, Compositions, Methods, and Uses
    4.
    发明申请
    Anti-PECAM Therapy, Compositions, Methods, and Uses 审中-公开
    抗PECAM治疗，组合，方法和用途

    公开(公告)号：US20120076795A1

    公开(公告)日：2012-03-29

    申请号：US13246543

    申请日：2011-09-27

    申请人： Robert DEBS

    发明人： Robert DEBS

    IPC分类号： A61K39/395 ,  A61P35/00

    CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/76

    摘要： The disclosure relates to the discovery that systemic administration of an antibody that binds to PECAM-1 increases body weight while suppressing the metastatic spread of a wide variety of different tumor types which are typically fatal in humans. This discovery provides a basis for the generation of novel treatments and medicaments, wherein provision of a systemic dosage of anti-pECAM-1 antibody or a proxy that provides the same functional result is administered to a patient suffering from cancer cachexia and/or metastasis associated with end-stage cancer

    摘要翻译： 本公开涉及以下发现：与PECAM-1结合的抗体的全身施用增加体重，同时抑制在人类中通常致命的多种不同肿瘤类型的转移扩散。 该发现为产生新的治疗和药物提供了基础，其中提供全身剂量的抗pECAM-1抗体或提供相同功能结果的代谢物被给予患有癌症恶病质和/或转移相关的患者 与终末期癌症

    REMOTE DETECTION OF SUBSTANCE DELIVERY TO CELLS
    6.
    发明申请
    REMOTE DETECTION OF SUBSTANCE DELIVERY TO CELLS 审中-公开
    远程检测物质输送到细胞

    公开(公告)号：US20110104261A1

    公开(公告)日：2011-05-05

    申请号：US12987028

    申请日：2011-01-07

    申请人： Daryl C. Drummond ,  Keelung Hong ,  Dmitri B. Kirpotin

    发明人： Daryl C. Drummond ,  Keelung Hong ,  Dmitri B. Kirpotin

    IPC分类号： A61K9/127 ,  G01N33/53

    CPC分类号： A61K49/1812 ,  A61B5/0059 ,  A61B5/055 ,  A61K9/1272 ,  A61K9/1273 ,  A61K47/10 ,  A61K47/14 ,  A61K47/18 ,  A61K47/36 ,  A61K47/6849 ,  A61K47/6913 ,  A61K49/0084 ,  A61K49/126 ,  A61K51/1234

    摘要： The present invention provides for the development of endocytosis-sensitive probes, and a remote method for measuring cellular endocytosis. These probes are based on the reduced water permeability of a nanoparticle or liposomal delivery system, and inherent degradability or disruption of barrier integrity upon endocytosis. The invention also provides for liposomes having combined therapeutic and diagnostic utilities by co-encapsulating ionically coupled diagnostic and therapeutic agents, in one embodiment, by a method using anionic chelators to prepare electrochemical gradients for loading of amphipathic therapeutic bases into liposomes already encapsulating an imaging agent. The invention provides for imaging of therapeutic liposomes by inserting a lipopolymer anchored, remotely sensing reporter molecules into liposomal lipid layer. The invention allows for an integrated delivery system capable of imaging molecular fingerprints in diseased tissues, treatment, and treatment monitoring.

    摘要翻译： 本发明提供了内吞作用敏感性探针的开发，以及用于测量细胞内吞作用的远程方法。 这些探针基于纳米颗粒或脂质体递送系统的降低的透水性，以及固有的降解性或内吞作用时屏障完整性的破坏。 本发明还提供了通过共包封离子偶联的诊断和治疗剂的组合治疗和诊断效用的脂质体，在一个实施方案中，通过使用阴离子螯合剂制备电化学梯度以将两亲性治疗碱加载到已经包封成像剂的脂质体中 。 本发明通过将锚定的脂质体聚合物远程感测报告分子进入脂质体脂质层来提供治疗性脂质体的成像。 本发明允许能够对患病组织，治疗和治疗监测中的分子指纹进行成像的综合递送系统。

    Camptothecin derivatives as chemoradiosensitizing agents
    7.
    发明授权
    Camptothecin derivatives as chemoradiosensitizing agents 有权
    喜树碱衍生物作为化学放射增敏剂

    公开(公告)号：US07875602B2

    公开(公告)日：2011-01-25

    申请号：US11444150

    申请日：2006-05-30

    申请人： Li-Xi Yang

    发明人： Li-Xi Yang

    IPC分类号： A61K31/33 ,  C07D491/00

    CPC分类号： C07D491/22 ,  A61K45/06

    摘要： Camptothecin-based compounds are useful for treating a neoplasm in mammalian subjects by administering such compound to the subjects in combination with radiotherapy, i.e., the treatment of tumors with radioactive substances or radiation from a source external to the subject. Camptothecin-based compounds are modified by positioning at least one electron-affinic group around the camptothecin structure to enhance their value in combination with radiotherapy. New Camptothecin-based compounds are disclosed that are useful for treating cancer by administering the novel compounds alone or in combination with radiotherapy.

    摘要翻译： 喜树碱类化合物可用于治疗哺乳动物受试者的肿瘤，其通过与受试者联合放射治疗，即用放射性物质治疗肿瘤或从受试者外部的来源辐射来治疗肿瘤。 通过在喜树碱结构周围定位至少一个电子亲和基团来改善喜树碱类化合物，以增强其与放射治疗相结合的价值。 公开了新的喜树碱类化合物，其可用于通过单独施用新化合物或与放射治疗组合来治疗癌症。