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公开(公告)号：US11525836B2
公开(公告)日：2022-12-13
申请号：US16095981
申请日：2017-05-12
发明人： Richard Wales , Patrick Courtney
摘要： A method for automating process development in a bioprocessing environment is provided. The method comprising: executing a first experiment run according to a set of parameters; retrieving a first real-time set of data of the experiment run while the experiment run is being executed; retrieving a second real-time set of data of an experiment run being executed in parallel, analysing the retrieved first real-time set of data and the second real-time set of data to determine an adjusted set of parameters; and, modifying, based on the analysis, the parameters upon which the experiment run is being executed during execution of the run such that the run continues to be executed according to the modified set of parameters. A system, computer program and computer readable medium are also provided.
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公开(公告)号：US11473047B2
公开(公告)日：2022-10-18
申请号：US16311522
申请日：2017-07-18
发明人： Paul Grant
摘要： A liquid filtration system comprising a syringe pump comprising a gas chamber and a movable plunger, wherein the gas chamber has an aperture at a first end and the plunger forms a seal within the internal walls of the chamber; a liquid chamber having two openings, the openings positioned at opposite ends of the chamber and the first opening connected to the aperture of the gas chamber; a bioreactor in fluidic communication with the second opening of the liquid chamber; a filter arranged to filter liquid passing between the bioreactor and the liquid chamber, the filter comprising a permeate outlet for removing filtered liquid; wherein, in use, the plunger may be moved in a reciprocating motion causing a corresponding movement of gas which drives liquid alternately between the liquid chamber and the bioreactor such that liquid passes through the filter and filtered liquid may be removed via the permeate outlet.
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公开(公告)号：US20200284644A1
公开(公告)日：2020-09-10
申请号：US16652976
申请日：2018-10-04
发明人： Adrian Neil Bargh , Stefanie Meyer
IPC分类号： G01G19/18 , B01D61/10 , B01D61/12 , B01D61/20 , B01D61/22 , B01D61/30 , B01D61/32 , B01D61/36
摘要： The present invention relates to a filtration system comprising a cabinet, a filtration device having a filtrate or retentate vessel arranged outside the cabinet, and a weighing device that is configured to weigh the filtrate or retentate vessel. The weighing device can be arranged inside an enclosure and the enclosure can be arranged inside the cabinet.
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4.发明申请公开(公告)号：US20200225156A1
公开(公告)日：2020-07-16
申请号：US16641224
申请日：2018-10-05
摘要： The present invention relates to devices and methods for improving and evaluating stability of pumped protein solutions in cross-flow filtration applications. Inter alia, the present invention provides a peristaltic pump for cross-flow filtration having a pump head, wherein the pump head comprises a stepped occlusion plate and at least one pump roller, wherein a tubing is to be arranged between the stepped occlusion plate and the at least one pump roller, wherein the stepped occlusion plate has a specific configuration.
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公开(公告)号：US10329524B2
公开(公告)日：2019-06-25
申请号：US14901390
申请日：2014-06-27
摘要： A bioreactor consumable unit (50; 500) comprises a bioreactor part (60); a fluid feed container part (80) integrally connected with the bioreactor part and including at least one fluid feed container (82) in fluid communication with the bioreactor (60); and an integral pumping element (100, 110; 160, 206) configured to enable fluid to flow from the at least one fluid feed container (82) to the bioreactor (60). The bioreactor part (60) includes a bioreactor chamber (62) and a stirrer (64) for agitation of a cell culture (66) in the chamber. The pumping element comprises a combination of a syringe pump (110) and an associated three-way valve (102). The bioreactor consumable unit (50; 500) may be inserted into a receiving station (20) of a cell culture module (10) for the processing and control of a bioreaction in the bioreactor chamber (62). The provision of the fluid feed containers (82) and the pumping element (100, 110; 60, 206) as integral parts of the bioreactor consumable unit (50; 500) facilitates the set-up of the processing, because the various fluid connections between those components are already established. The syringe pump (110) provides accurate dispensing of fluids to the bioreactor chamber (62).
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公开(公告)号：USRE45967E1
公开(公告)日：2016-04-12
申请号：US13762515
申请日：2013-02-08
发明人： Stephen Owen , Justin Michael Owen
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , F25D13/02 , F25D25/00 , Y10T436/113332
摘要： A system 10 for storing and processing a plurality of biological or chemical samples at ultra-low temperatures is provided. The system 10 comprises a plurality of ultra-low temperature storage locations 30; an enclosed pathway 35 adjacent the storage locations 30; and a manipulator module 60 disposed within the pathway 35 for conveying vessels 33 along the pathway 35 between the storage locations 30 in the system 10. Each of the storage locations being accessed through an insulated access panel 36 on the side of the storage location 30, the panel 36 being configured to close the storage location 30 from the pathway 35.
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公开(公告)号：USD632799S1
公开(公告)日：2011-02-15
申请号：US29326465
申请日：2008-10-18
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8.发明申请Bioreactor systems and associated methods of processing bioreactor vessels 有权生物反应器系统和加工生物反应器容器的相关方法公开(公告)号：US20110003323A1
公开(公告)日：2011-01-06
申请号：US12801559
申请日：2010-06-15
申请人： Adrian Neil Bargh
发明人： Adrian Neil Bargh
摘要： A bioreactor processing unit (10) includes at least one cell culture module (200) comprising: a base (202) including a receiving station (204) for removably receiving a plurality of bioreactor vessels (400) at respective locations (206); and a clamp plate (240). The clamp plate (240) is removably connectable to the base (202). The system further includes a drive mechanism (226) and multiple fluid conduits. When the system is to be used for an experiment run, vessels (400) are loaded into the receiving station (204) and the clamp plate (240) is connected to the base (202), forming a connection between the drive mechanism and the vessels, for transmitting input motion from the drive mechanism (226) into multiple rotary motion outputs for turning a stirrer (416) in each vessel (400). At the same time, connection of the clamp plate to the base forms a fluid connection between the multiple fluid conduits and an input port (412) in each respective vessel via associated multiple outlet ports (256) in the clamp plate and associated fluid connectors. The system further includes at least one sensor (126a, 126b) that is mounted so as to be movable to a position adjacent to each respective vessel location (206) for monitoring the contents of each vessel (400).
摘要翻译： 生物反应器处理单元（10）包括至少一个细胞培养模块（200），其包括：基部（202），包括用于在相应位置（206）可移除地接收多个生物反应器容器（400）的接收站（204） 和夹板（240）。 夹板（240）可拆卸地连接到基座（202）。 该系统还包括驱动机构（226）和多个流体管道。 当系统用于实验运行时，容器（400）被装载到接收站（204）中，并且夹板（240）连接到基座（202），形成驱动机构和 用于将来自驱动机构（226）的输入运动传送到用于转动每个容器（400）中的搅拌器（416）的多个旋转运动输出。 同时，夹板与底座的连接通过夹板中的相关多个出口（256）和相关联的流体连接器在多个流体管道和每个相应容器中的输入端口（412）之间形成流体连接。 该系统还包括至少一个传感器（126a，126b），其安装成可移动到与每个相应容器位置（206）相邻的位置，用于监测每个容器（400）的内容物。
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公开(公告)号：US07845149B2
公开(公告)日：2010-12-07
申请号：US11780526
申请日：2007-07-20
申请人： Stephen Owen , Justin Owen , Adrian Neil Bargh
发明人： Stephen Owen , Justin Owen , Adrian Neil Bargh
IPC分类号： B65B7/28
CPC分类号： G01N35/026 , B01L3/50825 , G01N2035/0405
摘要： A capper/de-capper system 1 has a rack support 10 for supporting a rack 11 containing a plurality of capped tubes 31 in a given position. A head unit 12 supports a two-dimensional array of capping/de-capping spindles 13, each of which includes a clutch 133 and a capping/de-capping spigot 131 or socket, the spindles being aligned with the tube positions defined in the rack. A drive mechanism 108 moves the tubes and the head unit relatively towards and away from one another in use, when a rack containing capped tubes is disposed in the rack support, causing engagement and disengagement of the capping/de-capping spigots or sockets with and from the tube caps 32. A spindle drive system 15-22 provides simultaneous rotation of the capping/de-capping spigots or sockets together after engagement with the caps, either to detach caps from the tubes or attach caps to the tubes.
摘要翻译： 封盖/去盖系统1具有支架10，用于支撑在给定位置上容纳多个封盖管31的支架11。 头单元12支撑封盖/去盖主轴13的二维阵列，每个阵列包括离合器133和封盖/脱帽插口131或插座，所述主轴与限定在机架中的管位置对准 。 驱动机构108在使用时使管和头单元彼此相对移动并远离彼此，当将包含封盖的管的架设置在机架支撑件中时，使得封盖/脱盖插口或插座与 主轴驱动系统15-22在与盖接合之后提供封盖/脱帽插口或插座的同时旋转，以从盖上卸下盖子或将盖子附接到管子上。
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公开(公告)号：US07513127B2
公开(公告)日：2009-04-07
申请号：US11224327
申请日：2005-09-13
申请人： Stephen Owen , Justin Michael Owen
发明人： Stephen Owen , Justin Michael Owen
CPC分类号： A01N1/02 , A01N1/0257 , A01N1/0263 , F25D13/02 , F25D25/00 , Y10T436/113332
摘要： A system 10 for storing and processing a plurality of biological or chemical samples at ultra-low temperatures is provided. The system 10 comprises a plurality of ultra-low temperature storage locations 30; an enclosed pathway 35 adjacent the storage locations 30; and a manipulator module 60 disposed within the pathway 35 for conveying vessels 33 along the pathway 35 between the storage locations 30 in the system 10. Each of the storage locations being accessed through an insulated access panel 36 on the side of the storage location 30, the panel 36 being configured to close the storage location 30 from the pathway 35.
摘要翻译： 提供了一种用于在超低温下存储和处理多个生物或化学样品的系统10。 系统10包括多个超低温存储位置30; 邻近存储位置30的封闭通道35; 以及设置在通道35内的操纵器模块60，用于沿着系统10中的存储位置30之间的路径35输送容器33.每个存储位置通过存储位置30侧的绝缘检修面板36进入， 面板36被配置为从路径35关闭存储位置30。
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