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公开(公告)号：US11123393B2
公开(公告)日：2021-09-21
申请号：US14305839
申请日：2014-06-16
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro Brownell , Min Chu , Mei-Feng Hong , Eu-Jin Hyun , Qi Jia , Ping Jiao , Hyun-Jin Kim , Mi-Ran Kim , Tae-Woo Kim , Bo-Su Lee , Young-Chul Lee , Breanna Moore , Jeong-Bum Nam , Mi-Sun Oh , Mi-Hye Park , Mesfin Yimam , Qian Zhang
IPC分类号： A61K36/605 , A61K36/48 , A61K31/7008 , A61K36/534 , A61K31/05 , A61K31/352 , A61K31/353 , A61K31/7028 , A61K31/7034
摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of modulating joint inflammation, joint pain, joint stiffness, cartilage degradation, or improving mobility, range of motion, flexibility, joint physical function, or any combination thereof. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other joint management agents, such as non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, glucosamine compounds, neuropathic pain relief agents, or the like.
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公开(公告)号：US20160263013A1
公开(公告)日：2016-09-15
申请号：US15031709
申请日：2014-10-30
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro Brownell , Min Chu , Brandon Corneliusen , Mei-Feng Hong , Ji-Hye Hwang , Eu-Jin Hyun , Qi Jia , Ping Jiao , Mi-Ran Kim , Bo-Su Lee , Young-Chul Lee , Jeong-Bum Nam , Mi-Sun Oh , Mesfin Yimam
CPC分类号： A61K8/97 , A61K8/0204 , A61K8/36 , A61K8/4926 , A61K8/4973 , A61K2800/42 , A61K2800/522 , A61K2800/5922 , A61Q19/00 , A61Q19/06 , A61Q19/08
摘要： The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.
摘要翻译： 本公开提供糖苹果和迷迭香提取物的混合物，任选地与花椒灰提取物组合用作皮肤护理组合物。
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公开(公告)号：US09844576B2
公开(公告)日：2017-12-19
申请号：US13904851
申请日：2013-05-29
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro Brownell , Byong-Il Choi , Brandon Corneliusen , Mei-Feng Hong , Eu-Jin Hyun , Qi Jia , Ping Jiao , Hyun-Jin Kim , Mi-Ran Kim , Tae-Woo Kim , Bo-Su Lee , Young-Chul Lee , Jeong-Bum Nam , Mesfin Yimam , Ji-Hye Hwang , Mi-Sun Oh
IPC分类号： A61K36/575 , A61K36/37 , A61K36/53 , A61K36/185 , A61K36/752 , A61K36/889 , A61K36/10 , A61K36/258 , A61K36/346 , A61K36/38 , A61K36/56 , A61K36/605 , A61K36/67 , A61K31/352 , A61K45/06 , A61K31/12 , A61K31/343
CPC分类号： A61K36/575 , A61K31/12 , A61K31/343 , A61K31/352 , A61K36/10 , A61K36/185 , A61K36/258 , A61K36/346 , A61K36/37 , A61K36/38 , A61K36/53 , A61K36/56 , A61K36/605 , A61K36/67 , A61K36/752 , A61K36/889 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.
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公开(公告)号：US20180099019A1
公开(公告)日：2018-04-12
申请号：US15838066
申请日：2017-12-11
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro Brownell , Byong-II Choi , Brandon Corneliusen , Mei-Feng Hong , Eu-Jin Hyun , QI Jia , Ping Jiao , Hyun-Jin Kim , Mi-Ran Kim , Tae-Woo Kim , Bo-Su Lee , Young-Chul Lee , Jeong-Bum Nam , Mesfin Yimam , Ji-Hye Hwang , Mi-Sun Oh
IPC分类号： A61K36/575 , A61K36/889 , A61K45/06 , A61K31/12 , A61K31/343 , A61K31/352 , A61K36/10 , A61K36/185 , A61K36/258 , A61K36/346 , A61K36/37 , A61K36/38 , A61K36/53 , A61K36/56 , A61K36/605 , A61K36/67 , A61K36/752
CPC分类号： A61K36/575 , A61K31/12 , A61K31/343 , A61K31/352 , A61K36/10 , A61K36/185 , A61K36/258 , A61K36/346 , A61K36/37 , A61K36/38 , A61K36/53 , A61K36/56 , A61K36/605 , A61K36/67 , A61K36/752 , A61K36/889 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.
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5.发明申请公开(公告)号：US20180055899A1
公开(公告)日：2018-03-01
申请号：US15663793
申请日：2017-07-30
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro Brownell , Min Chu , Mei-Feng Hong , Eu-Jin Hyun , Qi Jia , Ping Jiao , Hyun-Jin Kim , Mi-Ran Kim , Tae-Woo Kim , Young-Chul Lee , Jeong-Bum Nam , Mesfin Yimam
IPC分类号： A61K36/605 , A61K36/48 , A61K31/352 , A61K31/7034
CPC分类号： A61K36/605 , A61K9/2054 , A61K31/05 , A61K31/352 , A61K31/353 , A61K31/7008 , A61K31/7034 , A61K31/737 , A61K36/48 , A61K2300/00
摘要： The present disclosure provides mixtures of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both capable of useful for promoting, managing or improving bone health, cartilage health or both, or for preventing or treating a bone disorder, cartilage disorder or both. Such a mixture of prenylated flavonoids, stilbenes, or both with flavans or curcuminoids or both can optionally be used in combination with other bone and cartilage management agents, such as calcium, magnesium, zinc, boron, vitamin D, vitamin K, glucosamine and/or chondroitin compounds, non-steroidal anti-inflammatory agents/analgesics, COX/LOX inhibiting agents, neuropathic pain relief agents, or the like.
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公开(公告)号：US20140004215A1
公开(公告)日：2014-01-02
申请号：US13904851
申请日：2013-05-29
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro BROWNELL , Byong-Il CHOI , Brandon CORNELIUSEN , Mei-Feng HONG , Eu-Jin HYUN , Qi JIA , Ping JIAO , Hyun-Jin KIM , Mi-Ran KIM , Tae-Woo KIM , Bo-Su LEE , Young-Chul LEE , Jeong-Bum NAM , Mesfin YIMAN , Ji-Hye Hwang , Mi-Sun OH
IPC分类号： A61K36/575 , A61K36/53 , A61K36/185 , A61K36/37
CPC分类号： A61K36/575 , A61K31/12 , A61K31/343 , A61K31/352 , A61K36/10 , A61K36/185 , A61K36/258 , A61K36/346 , A61K36/37 , A61K36/38 , A61K36/53 , A61K36/56 , A61K36/605 , A61K36/67 , A61K36/752 , A61K36/889 , A61K45/06 , A61K2300/00
摘要： The present disclosure provides Diels-Alder adducts of chalcone and prenylphenyl moieties capable of modulating the activity of cannabinoid receptors, and to oligomers of flavan-3-ol capable of modulating fat absorption and storage. Such Diels-Alder adducts of chalcone and prenylphenyl moieties or oligomers of flavan-3-ol can optionally be used in combination with other weight management agents, such as anorectic agents, a lipase inhibitors, other cannabinoid receptor modulators, psychotropic agents, insulin sensitizers, stimulants, or satiety agents, as well as to methods of use thereof such as treating or preventing weight gain or obesity, promoting weight loss, appetite suppression, modifying satiety, or the like.
摘要翻译： 本公开提供了能够调节大麻素受体活性的查耳酮和异戊烯基苯基部分的狄尔斯 - 阿尔德加合物，以及能够调节脂肪吸收和储存的黄烷-3-醇的低聚物。 查耳酮和异戊基苯基部分或黄烷-3-醇的低聚物的这种Diels-Alder加合物可以任选地与其它重量控制剂，如厌食剂，脂肪酶抑制剂，其他大麻素受体调节剂，精神药物，胰岛素敏化剂， 兴奋剂或饱和剂，以及其使用方法，例如治疗或预防体重增加或肥胖，促进体重减轻，食欲抑制，改善饱腹感等。
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公开(公告)号：US12042523B2
公开(公告)日：2024-07-23
申请号：US18084009
申请日：2022-12-19
申请人： Unigen, Inc.
发明人： Qi Jia , Ping Jiao , Mesfin Yimam , Teresa Horm
IPC分类号： A61K36/00 , A61K31/352 , A61K31/353 , A61K31/7034 , A61K36/48 , A61K36/605
CPC分类号： A61K36/605 , A61K31/352 , A61K31/353 , A61K31/7034 , A61K36/48 , A61K2300/00 , A61K36/605 , A61K2300/00 , A61K36/48 , A61K2300/00 , A61K31/352 , A61K2300/00 , A61K31/7034 , A61K2300/00 , A61K31/353 , A61K2300/00
摘要： Compositions and methods for bone health, cartilage health or both, are disclosed that include preparing and utilizing a mixture of at least one Morus extract enriched for one or more prenylated flavonoids, at least one Scutellaria extract enriched for one or more free-B-ring flavonoids, and at least one Acacia extract enriched for one or more flavans.
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8.发明申请公开(公告)号：US20220031654A1
公开(公告)日：2022-02-03
申请号：US17389001
申请日：2021-07-29
申请人： Unigen, Inc.
发明人： Mesfin Yimam , Teresa Horm , Qi Jia , Lidia Brownell , Alexandria O'Neal
IPC分类号： A61K31/353 , A61K45/06 , A61P29/00 , A61P11/00
摘要： Bioflavonoid compositions for establishment and regulation of homeostasis of host defense mechanism, are disclosed and comprise at least one standardized bioflavonoid extract enriched for at least one free-B-ring flavonoid and at least one standardized bioflavonoid extract enriched for at least one flavan. Contemplated compositions are effective for respiratory diseases and conditions.
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公开(公告)号：US20200170907A1
公开(公告)日：2020-06-04
申请号：US16780018
申请日：2020-02-03
申请人： Unigen, Inc.
发明人： Qi Jia , Ji-Fu Zhao
IPC分类号： A61K8/34 , A61K8/49 , C07C41/32 , C07C41/26 , A61Q19/02 , C07C43/23 , C07D321/12 , C07C215/74 , C07C49/835 , C07C45/67 , C07C39/367 , C07C39/15 , A61K31/704 , A61K31/40 , A61K31/357 , A61K31/09 , A61K31/085 , A61K31/05 , A61K31/015 , A61K8/97 , A61K8/31
摘要： The present invention implements a strategy that combines an enzyme inhibition assay with a chemical dereplication process to identify active plant extracts and the particular compounds—diarylalkanes and/or diarylalkanols within those extracts that specifically inhibit binuclear enzyme function. Included in the present invention are compositions of matter comprised of one or more of diarylalkanes and/or diarylalkanols, which inhibit the activity of binuclear enzymes, particularly tyrosinase and which prevent melanin overproduction. The present invention also provides a method for inhibiting the activity of a binuclear enzyme, particularly tyrosinase and a method for preventing and treating diseases and conditions related to binuclear enzyme function. The present invention further includes a method for preventing and treating melanin overproduction and diseases and conditions of the skin related thereto. The method for preventing and treating diseases and conditions related to binuclear enzyme function and melanin overproduction is comprised of administering to a host in need thereof an effective amount of a composition comprising one or more diarylalkanes and/or diarylalkanols synthesized and/or isolated from one or more plants together with a pharmaceutically acceptable carrier.
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公开(公告)号：US10603270B2
公开(公告)日：2020-03-31
申请号：US15031709
申请日：2014-10-30
申请人： Unigen, Inc. , Unigen, Inc.
发明人： Lidia Alfaro Brownell , Min Chu , Brandon Corneliusen , Mei-Feng Hong , Ji-Hye Hwang , Eu-Jin Hyun , Qi Jia , Ping Jiao , Mi-Ran Kim , Bo-Su Lee , Young-Chul Lee , Jeong-Bum Nam , Mi-Sun Oh , Mesfin Yimam
摘要： The present disclosure provides a mixture of sugar apple and rosemary extracts, optionally in combination with prickly ash extract, for use as skin care compositions.
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