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公开(公告)号：US20230095566A1
公开(公告)日：2023-03-30
申请号：US17850577
申请日：2022-06-27
IPC分类号： C12N15/113
摘要： The present disclosure provides antisense compounds, methods, and compositions for silencing ADAM33 mRNA. The present disclosure provides antisense compounds, methods, and compositions for the treatment, prevention, or amelioration of diseases, disorders, and conditions associated with ADAM33 in a subject in need thereof. Also contemplated are antisense compounds and methods for the preparation of a medicament for the treatment, prevention, or amelioration of a disease, disorder, or condition associated with ADAM33.
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公开(公告)号：US20230006760A1
公开(公告)日：2023-01-05
申请号：US17756592
申请日：2020-11-26
发明人： Ke LI , David John THOMSON , Shenghao LIU , Graham Trevor REED , Weiwei ZHANG , Wei CAO
摘要： A method of generating multiple channels of optical pulses comprises: providing a continuous wave optical input having an optical power; dividing the optical power of the optical input into equal consecutive slices in the time domain; and allocating the consecutive slices sequentially to two or more optical outputs such that each output forms a channel of optical pulses of equal pulse repetition rate shifted in time relative to the or each other channel.
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公开(公告)号：US20220260363A1
公开(公告)日：2022-08-18
申请号：US17177785
申请日：2021-02-17
发明人： Christopher HOLMES , Janice BARTON , Daniel BULL
摘要： A method of measuring strain comprises providing laminated material comprising two or more ply layers and having a thickness along a direction orthogonal to a plane defined by the ply layers, and comprising a strain sensor embedded between adjacent ply layers, wherein: the strain sensor comprises a first planar optical waveguide and a second planar optical waveguide, each of the first planar optical waveguide and the second planar optical waveguide having a waveguiding core defining an optical propagation direction parallel to the plane of the laminated material and a Bragg grating in the waveguiding core, the optical propagation direction of the first planar optical waveguide being non-parallel to the optical propagation direction of the second planar waveguide; interrogating the Bragg grating of the first planar optical waveguide with transverse electric (TE) polarized light and with transverse magnetic (TM) polarized light to obtain a TE spectral response of the Bragg grating for the TE polarized light and a TM spectral response of the Bragg grating for the TM polarized light; interrogating the Bragg grating of the second planar optical waveguide with TE polarized light and with TM polarized light to obtain a TE spectral response of the Bragg grating for the TE polarized light and a TM spectral response of the Bragg grating for the TM polarized light; and processing the TE spectral response and the TM spectral response of the first planar optical waveguide and the TE spectral response and the TM spectral response of the second planar optical waveguide to extract at least a through-thickness component of strain within the laminated material which is aligned along the direction of the thickness of the laminated material.
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公开(公告)号：US20220259309A1
公开(公告)日：2022-08-18
申请号：US17627385
申请日：2020-07-17
发明人： Björn FRENDÉUS , Ingrid TEIGE , Linda MÅRTENSSON , Ingrid KARLSSON , Mark CRAGG , Stephen BEERS , Robert OLDHAM
摘要： Described is the combined use of a first antibody molecule that specifically binds FcyRIIb via its Fab region and that binds an Fey receptor via its Fc region, and a second antibody molecule that specifically binds PD-1 and that binds at least one Fey receptor via its Fc region, in the treatment of cancer in a patient having tumor infiltrating T lymphocytes with a medium or high PD-1 expression, as well as pharmaceutical compositions and kits comprising these two antibody molecules, and methods of treating cancer using these two antibodies. Described is also a diagnostic test for identification of patients benefitting from the treatment described herein.
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公开(公告)号：US20220233666A1
公开(公告)日：2022-07-28
申请号：US17264469
申请日：2020-10-19
发明人： Natalia SAVELYEVA , Gareth THOMAS , Christian OTTENSMEIER , Chuan WANG , Sok Ching CHEONG , Kue Peng LIM
摘要： The present invention relates to nucleic acid vaccines which encode at least a MAGED4B protein, for use in the treatment of cancer in particular. Synergistic combinations with other anti-cancer agents are described, particularly immune checkpoint inhibitors. The cancer vaccine may further comprise an immunologically active fragment to enhance the immune response, and an additional cancer antigen, such as FJX1. Particular combination therapies of interest include immunotherapies, radiotherapy, targeted therapies and chemotherapies.
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公开(公告)号：US20220111470A1
公开(公告)日：2022-04-14
申请号：US17297095
申请日：2019-11-26
发明人： Peter KAZANSKY , Masaaki SAKAKURA , Lei WANG
IPC分类号： B23K26/55 , G11C13/04 , B23K26/0622 , B23K26/00
摘要： A method of fabricating an optical element comprises: providing a substrate of a transparent material; applying a plurality of circularly polarised focused femtosecond laser pulses to a volume within the substrate to create substantially spherical nanopores in the volume; and applying at least one and not more than ten non-circularly polarised focused femtosecond laser pulses to the volume to transform the spherical nanopores into oblate spheroidal nanopores.
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公开(公告)号：US20220096614A1
公开(公告)日：2022-03-31
申请号：US17440067
申请日：2020-03-23
发明人： Salim Iqbal Khakoo
IPC分类号： A61K39/00 , G01N33/574 , C12N5/0783 , A61P35/00
摘要： The invention relates to a method of treatment or prophylaxis of cancer, wherein the cancer overexpresses exportin-1, the method comprising the administration of: a peptide capable of activating NK cell-mediated immunity to cancer cells that overexpress exportin-1, the peptide comprising or consisting of the amino acid sequence XnAX2X1, wherein Xn is an amino acid sequence of between 5 and 12 residues, and X1 is any amino acid; or leucine or phenylalanine; and X2 is alanine, threonine or serine; or administration of one or more of a nucleic acid encoding the peptide; an immunogenic composition comprising the peptide; a complex comprising the peptide; a vesicle comprising the peptide or nucleic acid encoding the peptide; a dendritic cell comprising the peptide and/or comprising nucleic acid encoding the peptide; an activated NK cell, that has been activated by the peptide; or a virus or virus like particle comprising the peptide and/or comprising nucleic acid encoding the peptide.
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公开(公告)号：US11256113B2
公开(公告)日：2022-02-22
申请号：US16324748
申请日：2017-08-09
发明人： Kapil Debnath , Graham Reed , Shinichi Saito
摘要： A method of fabricating an optical structure comprises providing a layer of single crystal crystalline silicon supported on an insulating surface of a silicon substrate; using etching to remove part of the silicon layer and define a side wall which is non-parallel to the insulating surface of the substrate; forming a layer of insulating material over the side wall; forming a further layer of silicon over at least the insulating material; and removing the silicon of the further layer to a level of the layer of silicon such that the layer of insulating material occupies a slot between a portion of silicon in the layer and a portion of silicon in the further layer, a thickness of the layer of insulating material defining a width of the slot.
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公开(公告)号：US20220031870A1
公开(公告)日：2022-02-03
申请号：US17395319
申请日：2021-08-05
发明人： Rajiv BHALLA , Gill REID , William LEVASON
IPC分类号： A61K51/04 , C07F5/00 , C07D255/02
摘要： A method of labelling biological molecules with 18F, via attachment of fluorine to a metal complex, where the metal complex is conjugated to the biological molecule. The invention highlights the incorporation of hydrogen bonding (H-bonding) into the metal complex scaffold, and how this can be utilized to improve the kinetics of fluoride incorporation. Also provided are pharmaceutical compositions, kits and methods of in vivo imaging.
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公开(公告)号：US11215751B2
公开(公告)日：2022-01-04
申请号：US16647118
申请日：2018-09-11
发明人： Francesco Poletti , Gregory Teofil Jasion , Natalie Wheeler , Thomas David Bradley , Mubassira B Syed Nawazuddin , John Hayes
IPC分类号： G02B6/02 , C03B37/012 , G02B6/024
摘要： A preform (10) for an antiresonant hollow core optical fibre comprises an outer jacket tube (12) having an inner surface and a central longitudinal axis (24); a plurality of antiresonant cladding tubes (14) spaced apart at predefined peripheral locations around the inner surface of the outer jacket tube (12), each antiresonant cladding tube (14) in contact with the inner surface such that a central longitudinal axis (26) of each antiresonant cladding tube (14) is at a first radial distance from the central longitudinal axis (24) of the outer jacket tube (12); and a plurality of spacing elements (22) disposed alternately with the antiresonant cladding tubes (14) and each in contact with an outer surface of each of two adjacent antiresonant cladding tubes (14) at one or more contact points (28), the contact points (28) at a second radial distance from the central longitudinal axis (24) of the outer jacket tube (12), the second radial distance being greater than the first radial distance.
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