公开(公告)号：US20240254256A1

公开(公告)日：2024-08-01

申请号：US18442889

申请日：2024-02-15

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Fabio Montrasio ,  Maria Grazia Barenco Montrasio ,  Jan Grimm ,  Roger Nitsch ,  Christoph Hock ,  Tobias Welt ,  Jordan McAfoose ,  Marcel Maier

IPC分类号： C07K16/40 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  A61K49/08 ,  A61K51/10 ,  C07K14/435 ,  C12N9/02 ,  G01N33/573 ,  G01N33/577 ,  G01N33/68

CPC分类号： C07K16/40 ,  A61K39/0005 ,  A61K39/3955 ,  A61K45/06 ,  A61K47/6871 ,  A61K49/085 ,  A61K51/10 ,  C07K14/435 ,  C12N9/0089 ,  G01N33/573 ,  G01N33/577 ,  G01N33/6893 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/92 ,  G01N2333/90283 ,  G01N2800/28 ,  G01N2800/285

摘要： Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.

公开(公告)号：US11971416B2

公开(公告)日：2024-04-30

申请号：US17342542

申请日：2021-06-09

申请人： YOKOGAWA ELECTRIC CORPORATION ,  University of Zurich

发明人： Takayuki Kei ,  Yohei Tsubouchi ,  Lucas Pelkmans ,  Gabriele Gut

IPC分类号： G01N33/58 ,  G01N1/30

CPC分类号： G01N33/582 ,  G01N1/30

摘要： An analysis apparatus (1) includes a housing unit (10) that houses a biological sample (S), a staining dispenser unit (20) that fluorescently stains the biological sample (S), an image acquisition unit (30) that acquires an image of the biological sample (S), a washer unit (40) that destains the biological sample (S), a drive unit (50), and a control unit (90) that analyzes the image and controls the drive unit (50). The control unit (90) performs adjustments so that the staining dispenser unit (20) and the housing unit (10) satisfy a first position condition, performs adjustments so that the image acquisition unit (30) and the housing unit (10) satisfy a second position condition, and performs adjustments so that the washer unit (40) and the housing unit (10) satisfy a third position condition. The analysis apparatus (1) maximizes the actual photography range of information related to the biological sample. The analysis apparatus (1) can also minimize variation in the time required for processes and can achieve high-quality analysis.

公开(公告)号：US20230071535A1

公开(公告)日：2023-03-09

申请号：US17470076

申请日：2021-09-09

申请人： GE Precision Healthcare LLC ,  University of Zurich

发明人： Sidharth Abrol ,  Bipul Das ,  Vanika Singhal ,  Amy Deubig ,  Sandeep Dutta ,  Daphné GERBAUD ,  Bianca Sintini ,  Ronny BÜCHEL ,  Philipp KAUFMANN

IPC分类号： G06T7/00 ,  G06T5/00 ,  G06T7/11 ,  G06N20/00 ,  G16H30/40 ,  G06K9/32

摘要： Systems/techniques that facilitate learning-based domain transformation for medical images are provided. In various embodiments, a system can access a medical image. In various aspects, the medical image can depict an anatomical structure according to a first medical scanning domain. In various instances, the system can generate, via execution of a machine learning model, a predicted image based on the medical image. In various aspects, the predicted image can depict the anatomical structure according to a second medical scanning domain that is different from the first medical scanning domain. In some cases, the first and second medical scanning domains can be first and second energy levels of a computed tomography (CT) scanning modality. In other cases, the first and second medical scanning domains can be first and second contrast phases of the CT scanning modality.

公开(公告)号：US20230021982A1

公开(公告)日：2023-01-26

申请号：US17822178

申请日：2022-08-25

申请人： KWS SAAT SE & Co. KGaA ,  UNIVERSITY OF ZURICH ,  UNIVERSITY OF BERN

发明人： Bettina KESSEL ,  Milena OUZUNOVA ,  Daniela SCHEUERMANN ,  Beat KELLER ,  Simon KRATTINGER ,  Coraline PRAZ ,  Ping YANG ,  Matthias ERB

IPC分类号： C12N15/82 ,  C12Q1/48 ,  C07K14/415 ,  A01H1/06 ,  A01H1/04 ,  A01H3/04 ,  C12Q1/6827 ,  C12Q1/6869

摘要： The present invention relates to methods for producing plants with increased fungal resistance, preferably seedling resistance against Northern Corn Leaf Blight. Further provided are methods for introducing, modifying, or modulating at least one wall-associated kinase (WAK) in(to) a plant cell, tissue, organ, or whole plant and thereby causing a reduced synthesis of benzoxazinoid and in turn increased fungal resistance. There are further provided methods to identify and/or modify downstream effector molecules in a WAK signalling cascade. Finally, plant cells, tissues, organs or whole plants having increased fungal resistance and methods using substances to activate signalling pathways in a targeted way are provided. The present invention thus relates to WAKs as master regulators and crucial signaling mediators in plant defense against fungal disease and the regulation and cross-talk mechanisms in the WAK signaling cascade and further gives examples for establishing novel anti-fungal strategies relevant for a series of crop plants.

公开(公告)号：US20220261649A1

公开(公告)日：2022-08-18

申请号：US17343001

申请日：2021-06-09

申请人： Samsung Electronics Co., Ltd. ,  University of Zurich

发明人： Chang GAO ,  Shih-Chii LIU ,  Tobi DELBRUCK ,  Xi CHEN

IPC分类号： G06N3/08 ,  G06N3/04

摘要： Disclosed is a neural network-based inference method and apparatus. The neural network-based inference method includes compressing a matrix comprising processing elements corresponding to an operation of a neural network, balancing workloads related to the operation by reordering the compressed matrix based on the workloads, and performing inference based on the reordered matrix.

公开(公告)号：US11352441B2

公开(公告)日：2022-06-07

申请号：US16424169

申请日：2019-05-28

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Fabio Montrasio ,  Maria Grazia Barenco Montrasio ,  Jan Grimm ,  Roger Nitsch ,  Christoph Hock ,  Tobias Welt ,  Jordan Mcafoose ,  Marcel Maier

IPC分类号： C07K16/40 ,  A61K39/00 ,  C07K14/435 ,  C12N9/02 ,  A61K47/68 ,  G01N33/68 ,  A61K39/395 ,  A61K45/06 ,  A61K49/08 ,  A61K51/10 ,  G01N33/573 ,  G01N33/577

摘要： Provided are novel human copper-zinc superoxide dismutase, also known as superoxide dismutase 1 or SOD1, specific antibodies as well as fragments, derivatives and variants thereof as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for SOD1 are also disclosed. The antibody, immunoglobulin chain(s), as well as binding fragments, derivatives and variants thereof can be used in pharmaceutical and diagnostic compositions for SOD1 targeted immunotherapy and diagnosis, respectively.

公开(公告)号：US10544213B2

公开(公告)日：2020-01-28

申请号：US15125450

申请日：2015-03-12

申请人： Neurimmune Holding AG ,  University of Zurich

发明人： Jan Grimm ,  Fabrice Heitz ,  Fabian Wirth ,  Tobias Welt

IPC分类号： C07K16/18 ,  A61K45/06 ,  C07K16/26 ,  A01K67/027 ,  A61K47/68 ,  A61P3/10 ,  A61K39/395 ,  A61K49/00 ,  A61K39/00

摘要： Described are molecules specifically binding to human islet amyloid polypeptide (hIAPP) also known as amylin, particularly human-derived antibodies as well as fragments, derivatives and variants thereof for antagonizing islet amyloid polypeptide (IAPP) induced β-cell damage and impaired glucose tolerance which are symptoms typically associated with diabetes mellitus type 2 (T2D).

公开(公告)号：US20190153082A1

公开(公告)日：2019-05-23

申请号：US16226409

申请日：2018-12-19

申请人： University of Zurich

发明人： Roger Nitsch ,  Christoph Hock ,  Christoph Esslinger ,  Marlen Knobloch ,  Kathrin Tissot ,  Jan Grimm

IPC分类号： C07K16/18 ,  A61K51/10 ,  G01N33/68 ,  A61K45/06 ,  C07K16/00

摘要： Provided are novel specific binding molecules, particularly human antibodies as well as fragments, derivatives and variants thereof that recognize neoepitopes of disease-associated proteins which derive from native endogenous proteins but are prevalent in the body of a patient in a variant form and/or out of their normal physiological context. In addition, pharmaceutical compositions comprising such binding molecules, antibodies and mimics thereof and methods of screening for novel binding molecules, which may or may not be antibodies as well as targets in the treatment of neurological disorders such as Alzheimer's disease are described.

公开(公告)号：US09828638B2

公开(公告)日：2017-11-28

申请号：US13823080

申请日：2011-09-19

申请人： Annelies Rotthier ,  Vincent Timmerman ,  Michaela Auer-Grumbach ,  Thorsten Hornemann

发明人： Annelies Rotthier ,  Vincent Timmerman ,  Michaela Auer-Grumbach ,  Thorsten Hornemann

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/156

摘要： Described are methods and kits for identifying a subject at risk of, or having, a sensory neuropathy related disease, such as sensory neuropathies. In particular, the disclosure is based on the determination of mutations in the SPTLC2 gene causing sensory neuropathies.

公开(公告)号：US09568366B2

公开(公告)日：2017-02-14

申请号：US14713329

申请日：2015-05-15

申请人： Wisconsin Alumni Research Foundation

发明人： Martin Thomas Zanni ,  Peter Hamm ,  Jan Helbing

IPC分类号： G01B9/02 ,  G01J3/457 ,  G01J3/433

CPC分类号： G01J3/457 ,  G01J3/433

摘要： A multidimensional spectrometer encodes frequency information into laser pulses so that a frequency insensitive detector may be used to collect data for a multi-dimensional spectrograph only from intensity information and knowledge of a modulation providing the encoding. In one embodiment the frequency encoding may be done by a conventional interferometer greatly simplifying construction of the spectrometer.

摘要翻译： 多维光谱仪将频率信息编码成激光脉冲，使得频率不敏感检测器可以仅用于从提供编码的调制的强度信息和知识中收集用于多维光谱仪的数据。 在一个实施例中，频率编码可以通过传统的干涉仪来完成，这大大简化了光谱仪的结构。