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公开(公告)号：US20240059694A1
公开(公告)日：2024-02-22
申请号：US18257027
申请日：2022-03-24
发明人： Yungen XU , Tingting LIANG , Qihua ZHU , Junjie WANG , Lifang CEN , Wenjie WANG , Jiaming JIN
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： The invention provides a compound containing a 1,3-benzodioxol structure and a preparation method and use thereof. The invention discloses a 1,3-benzodioxol derivative as shown in general formula (1). Results of pharmacological experiments indicate that compound (I) of the invention can exert excellent inhibition on both BTK and JAK3 kinases, and can be used to prepare medicines for treating rheumatoid arthritis caused by over-activation of BTK and/or JAK3 pathways. The invention further discloses a preparation method for the 1,3-benzodioxol derivative.
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公开(公告)号：US20240139152A1
公开(公告)日：2024-05-02
申请号：US18512564
申请日：2023-11-17
发明人： Weibo GUO , Dengke ZHANG , Weili JIN , Mingzhe JI , Yanxia ZHANG
IPC分类号： A61K31/4025 , A61K31/341 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4709 , A61K31/498 , A61K31/513 , A61K31/522 , A61K31/536 , A61K31/675 , A61K31/7056 , A61P31/20 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
CPC分类号： A61K31/4025 , A61K31/341 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4709 , A61K31/498 , A61K31/513 , A61K31/522 , A61K31/536 , A61K31/675 , A61K31/7056 , A61P31/20 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention provides anti-HBV compounds, pharmaceutically acceptable compounds or stereoisomers thereof, and preparation methods and uses for treating, eradicating or inhibiting HBV infection or for alleviating liver injury caused by HBV infection, and so on.
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公开(公告)号：US11903924B2
公开(公告)日：2024-02-20
申请号：US17593632
申请日：2020-01-20
发明人： Weibo Guo , Dengke Zhang , Weili Jin , Mingzhe Ji , Yanxia Zhang
IPC分类号： A61K31/4025 , A61P31/20 , A61K31/341 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4709 , A61K31/498 , A61K31/513 , A61K31/522 , A61K31/536 , A61K31/675 , A61K31/7056 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
CPC分类号： A61K31/4025 , A61K31/341 , A61K31/381 , A61K31/404 , A61K31/4178 , A61K31/4184 , A61K31/4192 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/427 , A61K31/428 , A61K31/4709 , A61K31/498 , A61K31/513 , A61K31/522 , A61K31/536 , A61K31/675 , A61K31/7056 , A61P31/20 , C07D263/34 , C07D277/56 , C07D307/68 , C07D333/38 , C07D405/12 , C07D405/14 , C07D407/12 , C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention provides anti-HBV compounds, pharmaceutically acceptable compounds or stereoisomers thereof, and preparation methods and uses for treating, eradicating or inhibiting HBV infection or for alleviating liver injury caused by HBV infection, and so on.
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公开(公告)号：US20220184035A1
公开(公告)日：2022-06-16
申请号：US17593632
申请日：2020-01-20
发明人： Weibo GUO , Dengke ZHANG , Weili JIN , Mingzhe JI , Yanxia ZHANG
IPC分类号： A61K31/4025 , C07D405/12 , C07D417/12 , C07D307/68 , C07D407/12 , C07D333/38 , C07D409/12 , C07D409/14 , C07D277/56 , C07D263/34 , C07D405/14 , C07D417/14 , A61K31/522 , A61K31/675 , A61K31/513 , A61K31/404 , A61K31/7056 , A61K31/536 , A61K31/341 , A61K31/4178 , A61K31/4192 , A61K31/427 , A61K31/381 , A61K31/421 , A61K31/42 , A61K31/4709 , A61K31/4184 , A61K31/423 , A61K31/428 , A61K31/498 , A61P31/20
摘要： The present invention provides anti-HBV compounds, pharmaceutically acceptable compounds or stereoisomers thereof, and preparation methods and uses for treating, eradicating or inhibiting HBV infection or for alleviating liver injury caused by HBV infection, and so on.
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