Synthetic novel pyrroloiminoquinone alkaloid and method of use

    公开(公告)号:US11325919B1

    公开(公告)日:2022-05-10

    申请号:US17420668

    申请日:2020-01-09

    申请人: Mark T. Hamann

    发明人: Mark T. Hamann

    IPC分类号: C07D495/22 A61P35/00

    摘要: Aleutianamine represents the first in a new class of pyrroloiminoquinone alkaloids possessing a highly strained multi-bridged ring system, discovered from Latrunculia (Latrunculia) austini Samaai, Kelly & Gibbons, 2006 (class Demospongiae, order Poecilosclerida, family Latrunculiidae) recovered during a NOAA deep-water exploration of the Aleutian Islands. Aleutianamine exhibited potent and selective cytotoxicity toward solid tumor cell lines including pancreatic cancer (PANC-1) with an IC50 of 25 nM and colon cancer (H116) with IC50 of 1 μM.

    Pharmaceutical formulation of arsenic trioxide

    公开(公告)号:US11583552B2

    公开(公告)日:2023-02-21

    申请号:US17410900

    申请日:2021-08-24

    申请人: Manoj Maniar

    发明人: Manoj Maniar

    IPC分类号: A61K33/36 A61K9/48

    摘要: Liquid fill matrices comprising dissolved arsenic trioxide and having not more than 20% aqueous component and at least 80% nonaqueous component, wherein the components are miscible, are described as well as processes of preparing such liquid fill matrices and processing the liquid fill matrices into dosage forms including soft capsules; for the treatment of various ailments, such as cancer and GVHD.