摘要:
Improved methods of native chemical ligation are provided. The methods involve reacting a thioacid (e.g. a peptide thioacid) with an aziridinyl compound (e.g. an aziridinyl peptide) under mild conditions without the use of protecting groups, and without requiring that a cysteine residue be present in the ligation product. Initial coupling of the thioacid and the aziridinyl compound yields a ligation product which contains an aziridinyl ring. Subsequent opening of the aziridinyl ring (e.g. via a nucleophilic attack) produces a linearized and modified ligation product.
摘要:
A tool, called the Skills Matching Application (SMA), allows a user, such as a hiring manager, to communicate requirements to technical service suppliers in a way that significantly reduces the process time and improves the accuracy of requests sent to suppliers. The SMA is accessed from a Web-based Requisition/Catalog (REQ/CAT) Web application. A user who needs to request a technical contractor accesses the REQ/CAT Web application which brings the user to the SMA Web site. The SMA application, after requiring a password and profile (for first time access) to be entered, takes the user through a series of screens which prompts the user to enter a Statement of Work (SOW) and complete a skills detail checklist for each of the technical skills requested. Once the request is completed, it is submitted to contracted suppliers who are sent an e-mail notification notifying the supplier that a new request has been entered into the SMA application for them to review and submit a candidate against. This e-mail has a standard formatted attachment which contains the statement of work and skills detail checklist. The suppliers, when they receive an e-mail request, access the Web site database to view the request details. A supplier provides a candidate or candidates by accessing the SMA Web site and submitting candidates and appending resumes as appropriate. The supplier provides a response to the SOW by responding to the entries with the candidate's skills, experience, etc. The requestor views the supplier responses and associated resumes and can either accept or reject each candidate submitted but cannot accept more than the number of candidates requested.
摘要:
Stabilization of water-containing solutions or lyophilizates of proteins and peptides against non-enzymatic deamidation degradation reactions at asparaginyl or glutaminyl residues is achieved using organic anions, such as saccharin, benzenesulfonic acid, gentisic acide or N-acetyltryptophan which have a pKa within the range of 0.5 to 3.5.
摘要:
A system and method automatically maps computer center rooms and locates data center components within computer centers. Radio triangulation is used to determine the locations and, optionally, orientation, of machines within a computer center.
摘要:
A cellular telephone set is capable of allowing release dial lock function by a child even when parent manages an identification number. A control portion of the cellular telephone set is responsive to input of identification number through a key operating portion after dial lock condition is established by dial lock means to make judgment whether the input identification number is a dial lock releasing number in a dial lock releasing number storage region. When the control portion makes judgment that the identification number is the dial lock releasing number, dial lock condition of a predetermined function preliminarily set in an identification number setting information storage region is released.
摘要:
After a change of location of an avatar in a virtual universe, an avatar is encouraged to remain at that location and avoid an immediate further or return change of location (e.g. by teleportation) by prioritizing rendering of objects such that objects most likely to be of interest to the avatar is performed prior to rendering of objects less likely to be of interest. Prioritization is performed by comparing metadata concerning objective(s) of the avatar and metadata of preferences of the avatar and objects in the avatar's inventory and/or implied from the avatar's activity history with metadata corresponding to objects at the location to which the avatar moves. Preferably, the metadata corresponding to the avatar is ranked in order of the number of occurrences of metadata terms and synonyms in metadata of the avatar.
摘要:
A prosthesis socket for receiving an amputation stump has at least one shell which has an arched, open cross-section, where the shell ends in the applied state overlap each other at least partially. At least one tensioning means is disposed on the shell to act in a circumferential direction for tensioning the shell ends relative to each other. The shell is being made of a dimensionally stable plastic having regions with varying elasticity. The proximal end of the socket is relatively more flexible. The inner surface of the socket includes a direction dependent surface to aid in holding the amputation stump. A connector for the distal prosthesis is preferentially positioned adjacent the patient's greater trochanter and is configured for pivotable bearing of the prosthesis with fixing devices to secure the orientation of the prosthesis relative to the socket.
摘要:
A inventive feeding mechanism continuously feeds and continuously subjects to shredding, cutting, recycling, sorting, or other processing, a load consisting of a mixture of different-thickness materials, such as a mixture of paper, compact disks (CDs), cassette tapes, videotapes, etc. The auto-adjusting feeding mechanism is useable in high-security destruction, food processing, recycling, sorting, processing, and other applications.