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公开(公告)号：US20230391839A1
公开(公告)日：2023-12-07
申请号：US18322507
申请日：2023-05-23
发明人： Harald Martijn Ijsbrand Kerkkamp , Michael Keith Richardson , Gilles Philippus van Wezel , Jan Wouter Drijfhout , Robert Alexander Cordfunke , Michella Manon Voet , Petrus Hendricus Nibbering
IPC分类号： C07K14/46
摘要： The disclosure concerns snake-derived peptides and the useful application of such peptides to inhibit bacterial, fungal, viral and parasitic infections. The disclosed peptides are also useful for the treatment of an inflammatory condition or cancers.
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公开(公告)号：US20230203448A1
公开(公告)日：2023-06-29
申请号：US18009231
申请日：2021-06-07
申请人： Erasmus University Medical Center Rotterdam , Academisch Ziekenhuis Leiden h.o.d.n. LUMC , Wageningen Universiteit
发明人： Alessandro IULIANO , Wilhelmus Wenceslaus Matthias PIJNAPPEL , Antje Tjitske VAN DER PLOEG , Vittorio SAGGIOMO , Jessica Christine DE GREEF , Erik VAN DER WAL , Silvere Maria VAN DER MAAREL
CPC分类号： C12N5/0658 , C12M21/08 , C12M23/16 , C12M25/14 , C12N2501/115 , C12N2501/727 , C12N2513/00 , B33Y10/00
摘要： A method of manufacturing a microstructure comprises printing a positive mold structure, filling the positive mold structure with a second material to form an elastically deformable negative mold structure, filling the negative mold structure with a third material to form the microstructure, and releasing the microstructure from the negative mold structure. Advantageously, the negative mold structure can be stretched to facilitate the release of the microstructure. For example, the microstructure comprises a chamber with capped micropillars for the generation and/or analysis of muscle tissue.
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公开(公告)号：US20230184758A1
公开(公告)日：2023-06-15
申请号：US18080342
申请日：2022-12-13
IPC分类号： G01N33/564 , G01N33/576
CPC分类号： G01N33/564 , G01N33/5767 , G01N2800/50 , G01N2440/38
摘要： The present invention relates to methods for diagnosing and/or predicting the risk of developing autoimmune hepatitis (AIH) in a subject. The methods are based on the inventors' identification of a novel biomarker for AIH. The invention further comprises the use of said biomarker in the methods disclosed herein, and kits comprising agents for detecting said biomarker. The invention also relates to a method of treating AIH in a subject, wherein the subject has been diagnosed with AIH or determined to be at risk of developing AIH using the methods disclosed herein.
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公开(公告)号：US20230035037A1
公开(公告)日：2023-02-02
申请号：US17780398
申请日：2020-11-25
摘要： Novel nucleic acid sequences, vectors, cells, binding agents, peptides and pharmaceutical compositions are provided that are useful as a medicament, for example in the prevention or treatment of cancer or viral infections associated with impaired HLA class I antigen presentation. Corresponding methods and uses are also provided.
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公开(公告)号：US20220281921A1
公开(公告)日：2022-09-08
申请号：US17625483
申请日：2020-07-07
发明人： Rob Cornelis HOEBEN , Selas BOTS , Vera KEMP
IPC分类号： C07K14/005 , C12N7/00 , A61P35/00
摘要： Novel nucleic acid sequences, vectors and adenoviral genomes are provided herein. Corresponding novel adenoviruses and genotypes and compositions are also provided. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are useful in therapy. The novel nucleic acid sequences, vectors, genomes, adenoviruses, genotypes and compositions are particularly useful in treating or preventing cancer.
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公开(公告)号：US20210010004A1
公开(公告)日：2021-01-14
申请号：US16977779
申请日：2019-03-01
IPC分类号： C12N15/113 , A61K31/7125
摘要： The invention relates to antisense molecules and methods for modulating splicing of polyomavirus T antigen pre-mRNA. In one aspect the invention relates to an antisense oligonucleotide 12 to 30, preferably 17, 18, 19 or 20 to 30 nucleobases in length which comprises a sequence that is the reverse complement of a contiguous stretch of at least 12 nucleobases of a polyomavirus T-antigen pre-mRNA and which antisense oligonucleotide can modulate splicing of said T-antigen pre-mRNA in a cell.
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7.发明申请公开(公告)号：US20200325487A1
公开(公告)日：2020-10-15
申请号：US15733261
申请日：2018-12-17
IPC分类号： C12N15/82
摘要： The present disclosure provides methods for transfecting plants and for expressing RNA or polypeptide molecules in plants. In particular, plants having reduced expression and/or activity of a component of the classical NHEJ pathway and a component of the POLQ pathway are transfected in order to reduce random integration events. The disclosure further provides transfected plants and plant progeny produced by the methods disclosed herein.
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公开(公告)号：US20200276441A1
公开(公告)日：2020-09-03
申请号：US16764127
申请日：2018-11-14
摘要： The present invention relates to a system, its catheter and its method for providing electrical pulses and/or therapeutic or diagnostic liquids directly to a pituitary gland of a mammal. The catheter, containing an electrode or a microcannula or both, is moved through an endovascular route of a patient to his/her sinus cavernosus and then the distal end of the electrode or microcannula is moved through an opening in the distal end of the catheter and then through a perforation in the medial wall of the sinus cavernosus, to the pituitary gland.
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公开(公告)号：US20200224203A1
公开(公告)日：2020-07-16
申请号：US16781903
申请日：2020-02-04
发明人： Wilhelmina M.C. van Roon-Mom , Melvin Maurice Evers , Barry Antonius Pepers , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
IPC分类号： C12N15/113 , C12N15/11
摘要： Described are methods for removing a proteolytic cleavage site, the HCHWA-D mutation or the amino acids encoded by a trinucleotide repeat expansion from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that comprises the proteolytic cleavage site, HCHWA-D mutation or trinucleotide repeat expansion, respectively, the method further comprising allowing translation of mRNA produced from the pre-mRNA.
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公开(公告)号：US10364432B2
公开(公告)日：2019-07-30
申请号：US15439776
申请日：2017-02-22
发明人： Wilhelmina M. C. van Roon-Mom , Melvin Maurice Evers , Barry Antonius Pepers , Annemieke Aartsma-Rus , Garrit-Jan Boudewijn Van Ommen
IPC分类号： C12N15/00 , C12N15/11 , C12N15/113
摘要： The invention relates to means and methods for removing a proteolytic cleavage site from a protein comprising providing a cell that expresses pre-mRNA encoding the protein with an anti-sense oligonucleotide that induces skipping of the exonic sequence that encodes the proteolytic cleavage site, the method further comprising allowing translation of mRNA produced from the pre-mRNA.
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