公开(公告)号：US12006298B2

公开(公告)日：2024-06-11

申请号：US17265757

申请日：2019-08-06

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Stephen Gitu Machatha ,  Jonathan J. Loughrey ,  Hannah Ruth Mclachlan ,  Gregor Sneddon

IPC: C07D263/57

CPC classification number: C07D263/57 ,  C07B2200/13

Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.

公开(公告)号：US20240174614A1

公开(公告)日：2024-05-30

申请号：US18341613

申请日：2023-06-26

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Thomas A. Jordan ,  John E. Dowling ,  John Clifford Chabala

IPC: C07D215/38 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D261/06 ,  C07D275/00 ,  C07D277/40 ,  C07D277/56 ,  C07D333/04

CPC classification number: C07D215/38 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D261/06 ,  C07D275/00 ,  C07D277/40 ,  C07D277/56 ,  C07D333/04

Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed

公开(公告)号：US11724987B2

公开(公告)日：2023-08-15

申请号：US17164556

申请日：2021-02-01

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Thomas A. Jordan ,  John E. Dowling ,  John Clifford Chabala

IPC: A61K31/4418 ,  A61K31/41 ,  A61K31/423 ,  C07D215/38 ,  A61K31/44 ,  A61K31/426 ,  A61K31/435 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/60 ,  C07D277/40 ,  C07D277/56 ,  C07D261/06 ,  C07D275/00 ,  C07D333/04 ,  C07C229/56 ,  A61K31/47

CPC classification number: C07D215/38 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D261/06 ,  C07D275/00 ,  C07D277/40 ,  C07D277/56 ,  C07D333/04

Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.

公开(公告)号：US20210393612A1

公开(公告)日：2021-12-23

申请号：US17334094

申请日：2021-05-28

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Stephen Gitu MACHATHA ,  Charles MONTGOMERY ,  Steven KRAUSERT ,  Jonathan James LOUGHREY ,  Hannah Ruth MCLACHLAN ,  Gregor SNEDDON

IPC: A61K31/47 ,  C07D215/38

Abstract: The present invention relates to free-base and salt forms, and compositions thereof of small molecule therapeutics acting as a scavenger for toxic aldehydes. The present invention further relates to use of the free-base and salt forms, and compositions thereof for treating diseases, disorders, or conditions in which aldehyde toxicity is implicated in their pathogenesis.

公开(公告)号：US20210269402A1

公开(公告)日：2021-09-02

申请号：US17164556

申请日：2021-02-01

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Thomas A. JORDAN ,  John E. DOWLING ,  John Clifford CHABALA

IPC: C07D215/38 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/60 ,  C07D277/40 ,  C07D277/56 ,  C07D261/06 ,  C07D275/00 ,  C07D333/04 ,  C07C229/56 ,  A61K31/47

Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.

公开(公告)号：US10426790B2

公开(公告)日：2019-10-01

申请号：US15445802

申请日：2017-02-28

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Scott Young ,  Todd Brady ,  Stephen Gitu Machatha ,  David Clark ,  Susan Macdonald

IPC: A61F9/00 ,  A61K9/00 ,  A61K9/08 ,  C08L5/16 ,  A61K31/724 ,  C08B37/16

Abstract: The present disclosure provides methods of treating eye allergies and allergic conjunctivitis with cyclodextrin. Ophthalmic compositions of cyclodextrin for topical administration are also provided.

公开(公告)号：US20180354905A1

公开(公告)日：2018-12-13

申请号：US15754065

申请日：2016-08-22

Applicant: ALDEYRA THERAPEUTICS, INC.

Inventor： Todd Brady ,  Scott Young ,  William A. Kinney ,  Susan Macdonald

IPC: C07D215/38 ,  A61K31/47 ,  A61K45/06 ,  A61P17/00 ,  A61P39/00

CPC classification number: C07D215/38 ,  A61K31/47 ,  A61K45/06 ,  A61P17/00 ,  A61P27/02 ,  A61P39/00 ,  C07B2200/05 ,  A61K2300/00

Abstract: The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.

公开(公告)号：US20180265474A1

公开(公告)日：2018-09-20

申请号：US15924005

申请日：2018-03-16

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Amanda BUIST ,  Eden FUCCI ,  Stephen G. MACHATHA ,  Osama SULEIMAN ,  Kate WITTERING

IPC: C07D215/38 ,  C07C309/04 ,  A61K31/47 ,  C07C309/29 ,  C07C55/07 ,  C07C309/25 ,  C07C59/255

Abstract: The present invention provides freebase and salt forms, and compositions and methods thereof, useful for treating various conditions, in which aldehyde toxicity is implicated in the pathogenesis, by the administration of small molecule therapeutics acting as a scavenger for toxic aldehydes.

公开(公告)号：US09265759B2

公开(公告)日：2016-02-23

申请号：US14581462

申请日：2014-12-23

Applicant: ALDEYRA THERAPEUTICS, INC.

Inventor： Thomas A. Jordan ,  John E. Dowling ,  John Clifford Chabala

IPC: A61K31/47 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D215/38 ,  C07D277/40 ,  C07D277/56

CPC classification number: C07D215/38 ,  A61K31/41 ,  A61K31/423 ,  A61K31/426 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/47 ,  A61K31/4706 ,  C07C215/68 ,  C07C229/56 ,  C07C229/60 ,  C07D277/40 ,  C07D277/56

Abstract: Compositions and methods for treating macular degeneration and other forms of retinal disease whose etiology involves the accumulation of A2E and/or lipofuscin, and, more specifically, for preventing the formation and/or accumulation of A2E are disclosed.

公开(公告)号：US12098132B2

公开(公告)日：2024-09-24

申请号：US17310104

申请日：2020-05-02

Applicant: Aldeyra Therapeutics, Inc.

Inventor： Stephen Gitu Machatha ,  Charles Montgomery

IPC: C07D215/38 ,  C07D215/48

CPC classification number: C07D215/38 ,  C07D215/48

Abstract: The present invention relates to methods for synthesizing compounds, and to intermediates thereto, useful for treating various conditions in which aldehyde toxicity is implicated in the pathogenesis.