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公开(公告)号:US20180185582A1
公开(公告)日:2018-07-05
申请号:US15736337
申请日:2016-07-11
申请人: ALK-Abelló A/S
发明人: Jens MIKKELSEN
IPC分类号: A61M5/20
CPC分类号: A61M5/2033 , A61M5/326 , A61M2005/206 , A61M2005/2073
摘要: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.
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公开(公告)号:US20190202875A1
公开(公告)日:2019-07-04
申请号:US16303980
申请日:2017-05-29
CPC分类号: C07K14/43531 , A61K39/35 , A61P37/08 , C12N15/70 , C12N15/86 , C12Q1/025 , G01N33/6878
摘要: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.
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公开(公告)号:US11020527B2
公开(公告)日:2021-06-01
申请号:US15736337
申请日:2016-07-11
申请人: ALK-Abelló A/S
发明人: Jens Mikkelsen
摘要: An injector is provided for performing an injection operation comprising a housing (104), a needle extendable from a front end of the housing, a rear end of the housing and a longitudinal axis extending between the front end and the rear end, a safety pin (116) in an actuation locked position coupled to the housing and moveable to a safety released position coupled to the housing. The injector is locked against actuation when the safety pin is in the actuation locked position and the injector is ready for actuation of the injection operation when the safety pin is in the safety released position.
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公开(公告)号:US10471008B2
公开(公告)日:2019-11-12
申请号:US15699116
申请日:2017-09-08
申请人: ALK-Abelló A/S
发明人: Henrik Hugo Jacobi , Annette Rømmelmayer Lundegaard , Christian Gauguin Houghton , Jan Søndergaard-Andersen , Stig Asmul-Olsen , Lise Lund Mærkedahl
IPC分类号: A61K9/00 , A61K39/00 , A61K45/06 , A61J1/03 , B65D75/32 , G01N33/15 , A61K9/20 , A61K39/35 , A61K39/36 , A61K9/19 , A61K9/70 , A61K39/39 , G01N33/94
摘要: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.
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公开(公告)号:US10556936B2
公开(公告)日:2020-02-11
申请号:US16303980
申请日:2017-05-29
摘要: The invention relates to novel immunogenic polypeptides identified in house dust mites and storage mites, which have the potential to be used in allergy immunotherapy, for diagnostic purposes, eventually via production of antibodies binding the polypeptide or for characterising allergen extracts of house dust mites and storage mites.
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公开(公告)号:US20180207228A1
公开(公告)日:2018-07-26
申请号:US15739440
申请日:2016-07-01
申请人: ALK-Abelló A/S
发明人: Claus Lundegaard , Shashank Gupta , Bjoern Peters , Susanne Sønderkær , Jens Brimnes , Peter Adler Würtzen , Helene Henmar , Thomas Christian Mygind , Lise Lund Mærkedahl
摘要: The invention relates to combinations of peptides derived from a portion of an amino sequence of a grass pollen allergen, e.g. the allergens Phl p 1, Phl p 2, Phl p 3, Phl p 4 and/or Phl p 5, or a peptide variant thereof. Such peptides comprise at least one T cell epitope mid a high number of patients in a worldwide population will have HLA Class II alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by grass pollen species.
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公开(公告)号:US20140206027A1
公开(公告)日:2014-07-24
申请号:US14198112
申请日:2014-03-05
申请人: ALK-Abelló A/S
发明人: Ulla Seppälä
IPC分类号: C12Q1/37
CPC分类号: C12Q1/37 , G01N33/6848 , G01N2458/15 , G01N2800/24
摘要: The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard peptide(s) having a sequence of amino acids which is identical with, and optionally unique for, a sequence to be found in the allergen to be quantified and optionally labelling said allergen calibration standard peptide(s), b) degrading the allergen sample to obtain a mixture of peptides, and optionally labelling said peptides with one or more labelling agent(s), wherein at least the peptides in the degraded allergen sample or the calibration standard peptides are labelled, and if both the peptides in the degraded allergen sample and the allergen calibration standard peptide(s) are labelled, the labelling agent(s) used for labelling the allergen calibration standard peptide(s) are different from the labelling agent(s) used for labelling the peptides of the degraded allergen sample, c) quantifying the absolute amount of allergen by correlating the amount of the allergen calibration standard peptide(s) with the amount of the corresponding peptide(s) of the degraded allergen sample by mass analysis.
摘要翻译: 本发明涉及定量变应原样品中过敏原绝对量的方法,其包括:a)提供已知量的一种或多种变应原校准标准肽,其具有与SEQ ID NO: 用于,要在量变的变应原中发现的序列,并任选地标记所述变应原校准标准肽,b)降解变应原样品以获得肽的混合物,并任选地用一种或多种标记试剂标记所述肽( s),其中至少降解的变应原样品中的肽或标准标准肽被标记,并且如果降解过敏原样品中的肽和变应原校准标准肽都被标记,则使用标记试剂 用于标记变应原校准标准肽不同于用于标记降解过敏原样品的肽的标记试剂,c)量化 通过质量分析将变应原校准标准肽的量与降解过的变应原样品的相应肽的量相关联来确定过敏原的绝对量。
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公开(公告)号:US11013781B2
公开(公告)日:2021-05-25
申请号:US15739440
申请日:2016-07-01
发明人: Claus Lundegaard , Shashank Gupta , Bjoern Peters , Susanne Sønderkær , Jens Brimnes , Peter Adler Würtzen , Helene Henmar , Thomas Christian Mygind , Lise Lund Mærkedahl , Alessandro Sette
摘要: The invention relates to combinations of peptides derived from a portion of an amino sequence of a grass pollen allergen, e.g. the allergens Phl p 1, Phl p 2, Phl p 3, Phl p 4 and/or Phl p 5, or a peptide variant thereof. Such peptides comprise at least one T cell epitope mid a high number of patients in a worldwide population will have HLA Class II alleles with the potential to bind the peptides of the peptide combinations. The invention also relates to the use of such peptide combinations in relieving an immune response caused by grass pollen species.
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公开(公告)号:US10023900B2
公开(公告)日:2018-07-17
申请号:US14198112
申请日:2014-03-05
申请人: ALK-Abelló A/S
发明人: Ulla Seppälä
IPC分类号: A61K38/00 , A61K38/04 , C07K2/00 , C07K4/00 , C07K5/00 , C07K7/00 , C07K14/00 , C07K16/00 , C07K17/00 , C12Q1/37 , G01N33/68
CPC分类号: C12Q1/37 , G01N33/6848 , G01N2458/15 , G01N2800/24
摘要: The invention relates to method for quantification of the absolute amount of allergen in an allergen sample comprising: a) providing a known amount of one or more allergen calibration standard peptide(s) having a sequence of amino acids which is identical with, and optionally unique for, a sequence to be found in the allergen to be quantified and optionally labelling said allergen calibration standard peptide(s), b) degrading the allergen sample to obtain a mixture of peptides, and optionally labelling said peptides with one or more labelling agent(s), wherein at least the peptides in the degraded allergen sample or the calibration standard peptides are labelled, and if both the peptides in the degraded allergen sample and the allergen calibration standard peptide(s) are labelled, the labelling agent(s) used for labelling the allergen calibration standard peptide(s) are different from the labelling agent(s) used for labelling the peptides of the degraded allergen sample, c) quantifying the absolute amount of allergen by correlating the amount of the allergen calibration standard peptide(s) with the amount of the corresponding peptide(s) of the degraded allergen sample by mass analysis.
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公开(公告)号:US20170367970A1
公开(公告)日:2017-12-28
申请号:US15699116
申请日:2017-09-08
申请人: ALK-Abelló A/S
发明人: Henrik Hugo Jacobi , Annette Rømmelmayer Lundegaard , Christian Gauguin Houghton , Jan Søndergaard Andersen , Stig Asmul-Olsen , Lise Lund Mærkedahl
IPC分类号: A61K9/00 , A61K9/19 , A61J1/03 , G01N33/15 , B65D75/32 , A61K39/39 , A61K39/36 , A61K39/35 , A61K9/70 , A61K9/20 , G01N33/94 , A61K45/06 , A61K39/00
CPC分类号: A61K9/006 , A61J1/035 , A61K9/0056 , A61K9/19 , A61K9/2018 , A61K9/2063 , A61K9/2095 , A61K9/7007 , A61K39/35 , A61K39/36 , A61K39/39 , A61K45/06 , A61K2039/542 , A61K2039/545 , B65D75/327 , G01N33/15 , G01N33/94 , G01N2800/24
摘要: The invention provides allergen containing pharmaceutical products and in particular fast-dispersing solid allergen dosage forms. In particular, fast-dispersing, non-compressed solid dosage forms suitable for oromucosal administration comprising a matrix and at least one allergen are provided. Suitable matrices are gelatine, starch and mannitol. Methods for the dosage forms are also provided.
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