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公开(公告)号:US20140051888A1
公开(公告)日:2014-02-20
申请号:US13955086
申请日:2013-07-31
IPC分类号: C07C209/88
CPC分类号: C07C209/88 , C07B2200/07 , C07C209/56 , C07C211/27
摘要: A novel stereochemical mixture of 1,6-diaryl-2,5-diaminohexanes, such as a mixture of stereoisomers of 1,6-diphenylhexane-2,5-diamine, is described. Also described are methods of preparing stereochemically pure 1,6-diaryl-2,5-diaminohexanes, and particularly stereochemically pure 1,6-diphenyl-2,5-diaminohexane. Also described is the use of both the mixture of stereoisomers and the individual stereoisomers.
摘要翻译: 描述了1,6-二芳基-2,5-二氨基己烷的新立体化合物混合物,例如1,6-二苯基己烷-2,5-二胺的立体异构体的混合物。 还描述了制备立体化学纯的1,6-二芳基-2,5-二氨基己烷,特别是立体化学纯的1,6-二苯基-2,5-二氨基己烷的方法。 还描述了立体异构体和各个立体异构体的混合物的使用。
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公开(公告)号:US10851063B2
公开(公告)日:2020-12-01
申请号:US16151798
申请日:2018-10-04
发明人: William Dubay , Alex Nichols , Wei Chen , Alec Brozell , Ajay Ryerson
IPC分类号: C07D221/28 , C07C59/255
摘要: A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.
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公开(公告)号:US20150114315A1
公开(公告)日:2015-04-30
申请号:US14068519
申请日:2013-10-31
CPC分类号: F17C9/02 , F17C2221/012 , F17C2221/013 , F17C2221/014 , F17C2227/0309 , F17C2250/0421 , F17C2270/05 , F22B1/021 , F22B1/16 , F22B27/00
摘要: A method for releasing an anhydrous gas in a gas phase at a target rate includes the step of obtaining a vessel at least partially filled with the anhydrous gas. The anhydrous gas is at least partially in a liquid phase and the vessel has an outlet for releasing the anhydrous gas in the gas phase. The method further includes releasing at least a portion of the anhydrous gas from the vessel through the outlet in the gas phase; applying a heat transfer fluid having a temperature of 32° F. to 150° F. to an exterior surface of the vessel during the releasing step, such that the anhydrous gas in the liquid phase is evaporated and the anhydrous gas in the gas phase is released at the target rate; and measuring starting and end weights of the vessel to monitor the releasing of the anhydrous gas in the gas phase.
摘要翻译: 以目标速率释放气相中的无水气体的方法包括获得至少部分填充有无水气体的容器的步骤。 无水气体至少部分为液相,容器具有用于释放气相中的无水气体的出口。 该方法还包括在气相中通过出口将至少一部分无水气体从容器中释放出来; 在释放步骤期间将温度为32°F至150°F的传热流体施加到容器的外表面,使得液相中的无水气体蒸发,气相中的无水气体为 以目标速度释放; 并测量容器的起始和终止重量以监测气相中无水气体的释放。
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公开(公告)号:US20210094977A1
公开(公告)日:2021-04-01
申请号:US17104770
申请日:2020-11-25
发明人: John JACOBSEN , Valerie CALDWELL , Chris DICUS , Patrick BERGET
IPC分类号: C07F9/6561 , G01N33/94
摘要: Methods for producing tenofovir disoproxil fumarate with improved purity are provided. In particular, methods for producing tenofovir disoproxil fumarate with reduced levels of chloromethyl isopropyl carbonate are described. Also described are compositions containing tenofovir disoproxil fumarate with improved purity, and an analysis method that can be used to determine the purity of such compositions with improved accuracy and sensitivity.
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公开(公告)号:US20200109119A1
公开(公告)日:2020-04-09
申请号:US16151798
申请日:2018-10-04
发明人: William DUBAY , Alex NICHOLS , Wei CHEN , Alec BROZELL , Ajay RYERSON
IPC分类号: C07D221/28 , C07C59/255
摘要: A method for producing substantially pure levorphanol and related compounds, when compared to the conventional process, is provided. In particular, a method for producing substantially pure levorphanol tartrate dihydrate is described. Also described are compositions comprising levorphanol and related compounds, particularly compositions comprising levorphanol tartrate dihydrate, levomethorphan, and norlevorphanol in which the levomethorphan and norlevorphanol are present in the composition in reduced levels.
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公开(公告)号:US10307431B2
公开(公告)日:2019-06-04
申请号:US15813736
申请日:2017-11-15
IPC分类号: A61K31/661 , A61K47/26 , A61K9/19
摘要: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
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公开(公告)号:US10149857B2
公开(公告)日:2018-12-11
申请号:US15454420
申请日:2017-03-09
IPC分类号: A61K31/661 , A61K47/26
摘要: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
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公开(公告)号:US20200207793A1
公开(公告)日:2020-07-02
申请号:US16234901
申请日:2018-12-28
发明人: John JACOBSEN , Valerie CALDWELL , Chris DICUS , Patrick BERGET
IPC分类号: C07F9/6561 , G01N33/94
摘要: Methods for producing tenofovir disoproxil fumarate with improved purity are provided. In particular, methods for producing tenofovir disoproxil fumarate with reduced levels of chloromethyl isopropyl carbonate are described. Also described are compositions containing tenofovir disoproxil fumarate with improved purity, and an analysis method that can be used to determine the purity of such compositions with improved accuracy and sensitivity.
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公开(公告)号:US20180256609A1
公开(公告)日:2018-09-13
申请号:US15813736
申请日:2017-11-15
IPC分类号: A61K31/661 , A61K47/26
CPC分类号: A61K31/661 , A61K9/19 , A61K47/26
摘要: An improved lyophilized cyclophosphamide solid composition is described. The lyophilized cyclophosphamide solid composition is thermally stable, contains anhydrous cyclophosphamide and mannitol, and is substantially free of cyclophosphamide monohydrate. A method for preparing the lyophilized cyclophosphamide solid composition is also provided.
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公开(公告)号:US20210171556A1
公开(公告)日:2021-06-10
申请号:US17105017
申请日:2020-11-25
发明人: John JACOBSEN , Valerie CALDWELL , Chris DICUS , Patrick BERGET
IPC分类号: C07F9/6561 , G01N33/94 , B01D3/36
摘要: Methods for producing tenofovir disoproxil fumarate with improved purity are provided. In particular, methods for producing tenofovir disoproxil fumarate with reduced levels of chloromethyl isopropyl carbonate are described. Also described are compositions containing tenofovir disoproxil fumarate with improved purity, and an analysis method that can be used to determine the purity of such compositions with improved accuracy and sensitivity.
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