公开(公告)号：US08557526B2

公开(公告)日：2013-10-15

申请号：US12535960

申请日：2009-08-05

申请人： Andrew K. Ottens ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

发明人： Andrew K. Ottens ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

IPC分类号： G01N33/53 ,  G01N33/566

CPC分类号： G01N33/6896 ,  G01N2800/28

摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.

摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。

公开(公告)号：US20080204043A1

公开(公告)日：2008-08-28

申请号：US11666397

申请日：2005-10-27

申请人： Kevin K.W. Wang ,  Andrew K. Ottens

发明人： Kevin K.W. Wang ,  Andrew K. Ottens

IPC分类号： G01N33/53 ,  B01J19/00 ,  G01N33/487

CPC分类号： B82Y15/00 ,  B82Y30/00 ,  G01N5/02 ,  G01N33/54373 ,  G01N35/08 ,  G01N2035/0097

摘要： A system and methods, thereof, monitor biomarkers from a patient suffering from neural injury in real-time. The system comprises a quartz crystal microbalance wherein a capture molecule specific for certain biomarkers is diagnostic of the type of neural injury, location of neural injury and the degree of severity of neural injury. The system, in particular, provides real-time continuous monitoring of a patient.

摘要翻译： 其系统和方法，实时监测患有神经损伤的患者的生物标志物。 该系统包括石英晶体微量天平，其中特定于某些生物标志物的捕获分子是诊断神经损伤的类型，神经损伤的位置和神经损伤的严重程度。 该系统特别提供对患者的实时连续监测。

公开(公告)号：US07645584B2

公开(公告)日：2010-01-12

申请号：US11396406

申请日：2006-03-31

申请人： Stanislav I. Svetlov ,  Ronald L. Hayes ,  Kevin K. W. Wang ,  Monika Oli ,  Andrew K. Ottens

发明人： Stanislav I. Svetlov ,  Ronald L. Hayes ,  Kevin K. W. Wang ,  Monika Oli ,  Andrew K. Ottens

IPC分类号： G01N33/53

CPC分类号： G01N33/573 ,  C12Q1/00 ,  G01N33/6893 ,  G01N2800/08 ,  G01N2800/085

摘要： Novel, sensitive and specific markers for diagnostics and monitoring of liver injuries, including, but not limited to ischemic liver damage, are provided. This includes identification several enzymes of arginine/urea/nitric oxide cycle, sulfuration enzymes and spectrin breakdown related products, among others.

摘要翻译： 提供了用于诊断和监测肝损伤的新型，敏感和特异性标记，包括但不限于缺血性肝损伤。 这包括鉴定几种精氨酸/尿素/一氧化氮循环酶，硫化酶和血影蛋白分解相关产物等。

公开(公告)号：US20120196307A1

公开(公告)日：2012-08-02

申请号：US13337588

申请日：2011-12-27

申请人： ANDREW K. OTTENS ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

发明人： ANDREW K. OTTENS ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

IPC分类号： G01N33/566 ,  C07K2/00

CPC分类号： G01N33/6896 ,  G01N2800/28

摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological samples after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (biological samples). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.

摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少，生物样品中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，可与人脑脊髓液（生物样品）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。

公开(公告)号：US20100047817A1

公开(公告)日：2010-02-25

申请号：US12535960

申请日：2009-08-05

申请人： Andrew K. Ottens ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

发明人： Andrew K. Ottens ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

IPC分类号： G01N33/53

CPC分类号： G01N33/6896 ,  G01N2800/28

摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.

摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。