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    IN VITRO DIAGNOSTIC DEVICES FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERS
    3.
    发明申请
    IN VITRO DIAGNOSTIC DEVICES FOR NERVOUS SYSTEM INJURY AND OTHER NEURAL DISORDERS 审中-公开
    用于神经系统损伤和其他神经疾病的体外诊断装置

    公开(公告)号：US20140303041A1

    公开(公告)日：2014-10-09

    申请号：US13470079

    申请日：2012-05-11

    申请人： Ronald Lawrence Hayes ,  Ka-Wang (Kevin) Wang ,  Andreas Jeromin ,  Ming-Cheng Liu ,  Monika Oli

    发明人： Ronald Lawrence Hayes ,  Ka-Wang (Kevin) Wang ,  Andreas Jeromin ,  Ming-Cheng Liu ,  Monika Oli

    IPC分类号： G01N33/68

    CPC分类号： G01N33/6896 ,  C07K16/18 ,  C12Q1/6883 ,  C12Q2600/158 ,  G01N2800/28 ,  G01N2800/52

    摘要： The present invention relates to an exemplary in vitro diagnostic (IVD) device used to detect the presence of and/or severity of neural injuries or neuronal disorders in a subject. The IVD device relies on an immunoassay which identifies biomarkers that are diagnostic of neural injury and/or neuronal disorders in a biological sample, such as whole blood, plasma, serum, cerebrospinal fluid (CSF). The inventive IVD device may measure one or more of several neural specific markers in a biological sample and output the results to a machine readable format wither to a display device or to a storage device internal or external to the IVD.

    摘要翻译： 本发明涉及用于检测受试者中神经损伤或神经元疾病的存在和/或严重程度的示例性体外诊断（IVD）装置。 IVD装置依赖于免疫测定，其识别诊断生物样品例如全血，血浆，血清，脑脊液（CSF）中的神经损伤和/或神经元紊乱的生物标志物。 本发明的IVD装置可以测量生物样品中的几种神经特异性标记物中的一种或多种，​​并将结果输出到显示装置或IVD内部或外部的存储装置的机器可读格式。

    Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury
    7.
    发明申请
    Synaptotagmin and Collapsin Response Mediator Protein as Biomarkers for Traumatic Brain Injury 有权
    Synaptotagmin和Collapsin Response Mediator Protein作为创伤性脑损伤的生物标志物

    公开(公告)号：US20100047817A1

    公开(公告)日：2010-02-25

    申请号：US12535960

    申请日：2009-08-05

    申请人： Andrew K. Ottens ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

    发明人： Andrew K. Ottens ,  Firas H. Kobaissy ,  Ka-Wang (Kevin) Wang ,  Ronald L. Hayes ,  Zhiqun Zhang ,  Ming Chen Liu ,  Monika Oli

    IPC分类号： G01N33/53

    CPC分类号： G01N33/6896 ,  G01N2800/28

    摘要： Collapsin response mediator proteins (CRMPs) decreased in tissue and increased in biological fluids after neural injury from traumatic brain injury (TBI). Significant decreases of CRMP1, CRMP2, CRMP4 and CRMP5 were accompanied by the appearance of distinct 58 kDa (CRMP-2) or 55 kDa (CRMP-4) breakdown products from proteolytic cleavage by calpain. Synaptotagmin breakdown products were also associated with TBI and could be detected along with intact protein in human cerebral spinal fluid (CSF). Both biomarkers were detected in human biofluid and related to recovery from traumatic brain injury.

    摘要翻译： 在创伤性脑损伤（TBI）神经损伤后，Collapsin反应介质蛋白（CRMPs）在组织中减少并且生物流体中增加。 CRMP1，CRMP2，CRMP4和CRMP5的显着降低伴随着由钙蛋白酶的蛋白水解切割引起的不同的58kDa（CRMP-2）或55kDa（CRMP-4）分解产物的出现。 Synaptotagmin分解产物也与TBI相关，并可与人脑脊髓液（CSF）中的完整蛋白一起检测。 在人类生物流体中检测到两种生物标志物，并与创伤性脑损伤恢复相关。