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公开(公告)号:US20150065493A1
公开(公告)日:2015-03-05
申请号:US14385232
申请日:2013-03-15
IPC分类号: A61L2/18 , A61K31/542
CPC分类号: A61L2/18 , A61K9/0048 , A61K31/542
摘要: Process of preparing sterile brinzolamide using ethylene-oxide gas sterilisation, sterile brinzolamide obtainable by said process and pharmaceutical compositions comprising said sterile brinzolamide.
摘要翻译: 使用环氧乙烷气体灭菌法制备无菌布林唑胺的方法,通过所述方法获得的无菌布林佐胺和包含所述无菌布林佐胺的药物组合物。
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公开(公告)号:US20190040070A1
公开(公告)日:2019-02-07
申请号:US16073897
申请日:2017-02-08
发明人: Thomas MAIER , Inna KARAPETYAN , Alvard ARAKELYAN , Tamara MARGARYAN , Vardan SARGSYAN , Heghine STEPANYAN , Hermine ABOVYAN , Roman GERBER AESCHBACHER , Sven HAFERKAMP
IPC分类号: C07D487/04 , A61K9/20
摘要: Disclosed herein is a new route of synthesis and a new stable amorphous form of ibrutinib. Also disclosed are pharmaceutical compositions, oral dosage forms and the use of the amorphous ibrutinib in the treatment of mantle cell lymphoma or chronic lymphocytic leukemia.
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公开(公告)号:US20180273477A1
公开(公告)日:2018-09-27
申请号:US15935558
申请日:2018-03-26
发明人: Christian Manfred FRECH , Pasquale Gabriele GRIECO , Christine AEBERSOLD , Patrick MÜLLER , Jan-Erik INGENHOFF , Miriam OBERHOLZER , Viktorya RSTAKYAN , Roman Gerber AESCHBACHER
IPC分类号: C07D213/40
CPC分类号: C07D213/40 , C07D213/56
摘要: The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable pharmaceutical compositions and the use of the compound for the treatment of basal-cell carcinomas are disclosed.
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公开(公告)号:US20170166516A1
公开(公告)日:2017-06-15
申请号:US15118119
申请日:2015-02-10
IPC分类号: C07C215/54 , C07C213/10
CPC分类号: C07C215/54 , C07B2200/13 , C07C213/10
摘要: The present disclosure relates to Tapentadol Hydrochloride in the polymorphic crystalline Form B, which is substantially free of polymorphic Form A as well as essentially free of low alkyl carboxylic acids or esters of such acids. Furthermore, the present disclosure provides a process to produce this polymorphic Form B substantially free of Form A and its preparation and use for pharmaceutical compositions. This process as well as the specific crystalline form is uncommon, improved and industrially advantageous. Furthermore, the disclosure relates to pharmaceutical compositions and uses thereof.
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公开(公告)号:US10343998B2
公开(公告)日:2019-07-09
申请号:US15935558
申请日:2018-03-26
发明人: Christian Manfred Frech , Pasquale Gabriele Grieco , Christine Aebersold , Patrick Müller , Jan-Erik Ingenhoff , Miriam Oberholzer , Viktorya Rstakyan , Roman Gerber Aeschbacher
IPC分类号: C07D213/40 , C07D213/56
摘要: The present invention relates to a new route of synthesis to obtain pharmaceutically acceptable Vismodegib. In addition, besides the synthesis also suitable pharmaceutical compositions and the use of the compound for the treatment of basal-cell carcinomas are disclosed.
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公开(公告)号:US20180370958A1
公开(公告)日:2018-12-27
申请号:US16020228
申请日:2018-06-27
发明人: Christian Frech NABOLD , Christine AEBERSOLD , Pasquale Gabriele GRIECO , Roman Gerber AESCHBACHER
IPC分类号: C07D413/04
摘要: The present invention relates to a new route of synthesis for obtaining Opicapone ((4Z)-4-[3-(2,5-dichloro-4,6-dimethyl-1-oxidopyridin-1-ium-3-yl)-2H-1,2,4-oxadia-zol-5-ylidene]-2-hydroxy-6-nitrocyclohexa-2,5-dien-1-one), new intermediates in the reaction path and the new substance 2,5-dichloro-N-hydroxy-4,6-dimethylpyridine-3-carboximidoyl chloride.
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