公开(公告)号：US08541232B2

公开(公告)日：2013-09-24

申请号：US12224913

申请日：2007-03-08

Applicant: Yael Porat ,  Valentin Fulga ,  Svetlana Porozov ,  Adina Belleli

Inventor： Yael Porat ,  Valentin Fulga ,  Svetlana Porozov ,  Adina Belleli

IPC: C12N5/074 ,  C12N5/0781 ,  C12N5/00 ,  C12Q1/02 ,  C12N5/078 ,  C12N5/0797

CPC classification number: C12N5/0692 ,  A61K35/44 ,  A61K2035/124 ,  C12N5/0607 ,  C12N5/0634 ,  C12N2501/14 ,  C12N2501/165 ,  C12N2501/23 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2501/599 ,  C12N2501/91 ,  C12N2506/11 ,  C12N2510/00 ,  C12N2533/52 ,  C12N2533/54

Abstract: A population of cultured cells is provided that comprises at least 10% of a sub-population of cells that: stain as CD31 Bright, demonstrate uptake of Ac-LDL+, and secrete both IL-8 and angiogenin.

Abstract translation: 提供培养细胞群，其包含至少10％的细胞亚群：染色为CD31 Bright，显示Ac-LDL +的摄取，并分泌IL-8和血管生成素。

公开(公告)号：US20100291610A1

公开(公告)日：2010-11-18

申请号：US12224913

申请日：2007-03-08

Applicant: Yael Porat ,  Valentin Fulga ,  Svetlana Porozov ,  Adina Belleli

Inventor： Yael Porat ,  Valentin Fulga ,  Svetlana Porozov ,  Adina Belleli

IPC: C12N5/0735 ,  C12Q1/02

CPC classification number: C12N5/0692 ,  A61K35/44 ,  A61K2035/124 ,  C12N5/0607 ,  C12N5/0634 ,  C12N2501/14 ,  C12N2501/165 ,  C12N2501/23 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2501/599 ,  C12N2501/91 ,  C12N2506/11 ,  C12N2510/00 ,  C12N2533/52 ,  C12N2533/54

Abstract: A composition of matter is provided, comprising a population of cultured cells that comprises a sub-population of cells that both stain as CD31Bright and demonstrate uptake of Ac-LDL+, and secrete IL-8. A method is also provided, comprising stimulating in vitro an initiating cell population (ICP) of at least 5 million cells that have a density of less than 1.072 g/ml, wherein at least 1% of the cells of the ICP is CD34+CD45−/Dim, and at least 25% of the cells of the ICP are CD31Bright, to differentiate into a progenitor/precursor cell population (PCP). Other embodiments are also described.

Abstract translation: 提供了一种物质组合物，其包含培养细胞群，其包含染色为CD31Bright并显示Ac-LDL +的摄取并分泌IL-8的细胞亚群。 还提供了一种方法，其包括在体外刺激至少500万个细胞的起始细胞群（ICP），其密度小于1.072g / ml，其中ICP的至少1％的细胞是CD34 + CD45 - / Dim，并且ICP的至少25％的细胞是CD31Bright，以分化成祖细胞/前体细胞群体（PCP）。 还描述了其它实施例。

公开(公告)号：US20160145579A1

公开(公告)日：2016-05-26

申请号：US14942259

申请日：2015-11-16

Applicant: Yael Porat ,  Valentin Fulga ,  Svetlana Porozov ,  Adina Belleli

Inventor： Yael Porat ,  Valentin Fulga ,  Svetlana Porozov ,  Adina Belleli

IPC: C12N5/071 ,  A61K35/44

CPC classification number: C12N5/0692 ,  A61K35/44 ,  A61K2035/124 ,  C12N5/0607 ,  C12N5/0634 ,  C12N2501/14 ,  C12N2501/165 ,  C12N2501/23 ,  C12N2501/33 ,  C12N2501/39 ,  C12N2501/392 ,  C12N2501/599 ,  C12N2501/91 ,  C12N2506/11 ,  C12N2510/00 ,  C12N2533/52 ,  C12N2533/54

Abstract: Provided are methods for producing progenitor/precursor cells from a population of initiating cells (ICP) that have a density of less than 1.072 g/ml and at least 25% of which are CD31Bright by in vitro stimulating the ICP with different factors.