公开(公告)号：US08140167B2

公开(公告)日：2012-03-20

申请号：US11943069

申请日：2007-11-20

申请人： Adrianus Donders ,  Mark Raymond Stultz ,  Koen Jacob Weijand

发明人： Adrianus Donders ,  Mark Raymond Stultz ,  Koen Jacob Weijand

IPC分类号： A61N1/372

CPC分类号： A61N1/36007 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/37229 ,  A61N1/3752 ,  A61N1/3787

摘要： A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The external component can be configured into one of multiple selectable operating modes. The therapy system also may include a first external antenna configured to communicate with the implantable component and a second external antenna configured to communicate with the implantable component. Plugging one of the external antennas into the external component automatically configures the external component into one of the operating modes.

摘要翻译： 用于将电信号施加到患者的内部解剖特征的治疗系统包括可植入部件和外部部件。 外部组件可以配置成多种可选操作模式之一。 治疗系统还可以包括被配置为与可植入部件通信的第一外部天线和被配置为与可植入部件通信的第二外部天线。 将一个外部天线插入外部组件会自动将外部组件配置为其中一种工作模式。

公开(公告)号：US06740076B2

公开(公告)日：2004-05-25

申请号：US10132320

申请日：2002-04-26

申请人： Richard Hoben ,  Adrianus Donders

发明人： Richard Hoben ,  Adrianus Donders

IPC分类号： A61K922

CPC分类号： A61M5/14276 ,  A61B2090/062 ,  A61M5/427 ,  A61M39/0208 ,  A61M39/04 ,  A61M2039/0244 ,  A61M2205/14

摘要： Methods and systems for monitoring the condition of a septum in an implantable medical device are disclosed. Monitoring of the septum provides the ability to determine whether a needle has pierced the septum to effect the transfer of fluids into or out of a reservoir in the implantable medical device. Septum monitoring may provide the ability to determine whether the septum is maintaining its ability to seal the reservoir against leakage. The systems of the present invention include an ultrasonic transducer acoustically coupled to the septum to emit ultrasonic energy directly into the septum. Insertion of a needle through the septum can be detected by the acoustical changes caused by the needle located within the septum.

摘要翻译： 公开了用于监测可植入医疗装置中的隔膜状况的方法和系统。 隔膜的监测提供了确定针是否穿过隔膜以实现流体进入或流出可植入医疗装置中的储存器的能力。 隔垫监测可以提供确定隔膜是否保持其密封储存器以防泄漏的能力的能力。 本发明的系统包括声学耦合到隔膜的超声波换能器，以将超声能量直接发射到隔膜中。 通过隔膜插入针头可以通过由位于隔膜内的针引起的声学变化来检测。

公开(公告)号：US20070073354A1

公开(公告)日：2007-03-29

申请号：US11235947

申请日：2005-09-26

申请人： Mark Knudson ,  Adrianus Donders ,  Timothy Conrad

发明人： Mark Knudson ,  Adrianus Donders ,  Timothy Conrad

IPC分类号： A61N1/00

CPC分类号： A61N1/36071 ,  A61N1/0531 ,  A61N1/0534 ,  A61N1/0551 ,  A61N1/36064 ,  A61N1/36067

摘要： A method and apparatus are disclosed for treating a variety of conditions include treating a disorder associated with neural activity near a region of a brain. In such condition, the method includes placing an electrode to create a field near said region, creating said field with parameters selected to at least partially block neural activity within said field. For treating a tissue sensation, the method includes identifying a target area of tissue to be treated and placing an electrode to create a field near the target area, and creating the field with parameters selected to at least partially block neural activity within the target area. For treating a condition associated with neural activity of a spinal cord, the method includes placing an electrode to create a field near a nerve associated with the spinal cord, and creating the field with parameters selected to at least partially block neural activity within the nerve.

摘要翻译： 公开了用于治疗各种病症的方法和装置，包括治疗与脑区域附近的神经活动相关的病症。 在这种情况下，该方法包括放置电极以在所述区域附近产生场，产生具有选择以至少部分地阻止所述场内的神经活动的参数的所述场。 为了治疗组织感觉，所述方法包括识别待治疗的组织的靶区域并放置电极以在目标区域附近产生场，以及创建具有选择以至少部分阻断目标区域内的神经活动的参数的场。 为了治疗与脊髓的神经活动相关的病症，所述方法包括放置电极以产生与脊髓相关的神经附近的场，以及创建具有选择以至少部分阻断神经内的神经活动的参数的场。

公开(公告)号：US20060224326A1

公开(公告)日：2006-10-05

申请号：US11096434

申请日：2005-03-31

申请人： John St. Ores ,  Sarah Audet ,  James Carney ,  Janell Gottesman ,  Adrianus Donders ,  Michael Ujhelyi

发明人： John St. Ores ,  Sarah Audet ,  James Carney ,  Janell Gottesman ,  Adrianus Donders ,  Michael Ujhelyi

IPC分类号： G06F19/00

CPC分类号： G06Q50/24 ,  G16H10/20

摘要： A data collection system includes remote, implantable sensors for monitoring one or more patient parameters, collecting and processing data from those sensors and utilizing that data in the performance of a clinical study of a drug or other pharmacological agent. The system assists with preparation of a protocol for a clinical trial; presentation of that protocol; assuring compliance with the protocol; and generating useful results from data collected via the system and externally for presentation to an approval forum.

公开(公告)号：US08532787B2

公开(公告)日：2013-09-10

申请号：US11943054

申请日：2007-11-20

申请人： Scott Anthony Lambert ,  Adrianus Donders

发明人： Scott Anthony Lambert ,  Adrianus Donders

IPC分类号： A61N1/372

CPC分类号： A61N1/36007 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/37229 ,  A61N1/3752 ,  A61N1/3787

摘要： A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The implantable component is configured to receive a selected therapy program and a selected therapy schedule from the external component. The implantable component is adapted to be selectively configured into one of a training mode and a delivery mode. The implantable component is configured to apply therapy to the internal anatomical feature in accordance with the selected therapy program and the selected therapy schedule when configured in the delivery mode. The implantable component is configured to simulate application of therapy when configured in the training mode.

摘要翻译： 用于将电信号施加到患者的内部解剖特征的治疗系统包括可植入部件和外部部件。 可植入组件被配置为从外部组件接收所选择的治疗程序和选定的治疗方案。 可植入部件适于被选择性地配置成训练模式和传送模式之一。 可植入组件被配置为当在递送模式下配置时，根据所选择的治疗程序和所选择的治疗计划，将治疗应用于内部解剖特征。 可植入组件被配置为在训练模式下配置时模拟治疗的应用。

公开(公告)号：US20080300656A1

公开(公告)日：2008-12-04

申请号：US11943069

申请日：2007-11-20

申请人： Adrianus Donders ,  Mark Raymond Stultz ,  Koen Jacob Weijand

发明人： Adrianus Donders ,  Mark Raymond Stultz ,  Koen Jacob Weijand

IPC分类号： A61N1/08

CPC分类号： A61N1/36007 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/37229 ,  A61N1/3752 ,  A61N1/3787

摘要： A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The external component can be configured into one of multiple selectable operating modes. The therapy system also may include a first external antenna configured to communicate with the implantable component and a second external antenna configured to communicate with the implantable component. Plugging one of the external antennas into the external component automatically configures the external component into one of the operating modes.

摘要翻译： 用于将电信号施加到患者的内部解剖特征的治疗系统包括可植入部件和外部部件。 外部组件可以配置为多种可选操作模式之一。 治疗系统还可以包括被配置为与可植入部件通信的第一外部天线和被配置为与可植入部件通信的第二外部天线。 将一个外部天线插入外部组件会自动将外部组件配置为其中一种工作模式。

公开(公告)号：US20080300654A1

公开(公告)日：2008-12-04

申请号：US11943054

申请日：2007-11-20

申请人： Scott Anthony Lambert ,  Adrianus Donders

发明人： Scott Anthony Lambert ,  Adrianus Donders

IPC分类号： A61N1/02

CPC分类号： A61N1/36007 ,  A61N1/0556 ,  A61N1/0558 ,  A61N1/37229 ,  A61N1/3752 ,  A61N1/3787

摘要： A therapy system for applying an electrical signal to an internal anatomical feature of a patient includes an implantable component and an external component. The implantable component is configured to receive a selected therapy program and a selected therapy schedule from the external component. The implantable component is adapted to be selectively configured into one of a training mode and a delivery mode. The implantable component is configured to apply therapy to the internal anatomical feature in accordance with the selected therapy program and the selected therapy schedule when configured in the delivery mode. The implantable component is configured to simulate application of therapy when configured in the training mode.

摘要翻译： 用于将电信号施加到患者的内部解剖特征的治疗系统包括可植入部件和外部部件。 可植入组件被配置为从外部组件接收所选择的治疗程序和选定的治疗方案。 可植入部件适于被选择性地配置成训练模式和传送模式之一。 可植入组件被配置为当在递送模式下配置时，根据所选择的治疗程序和所选择的治疗计划，将治疗应用于内部解剖特征。 可植入组件被配置为在训练模式下配置时模拟治疗的应用。

公开(公告)号：US20060224421A1

公开(公告)日：2006-10-05

申请号：US11097685

申请日：2005-03-31

申请人： John St. Ores ,  Sarah Audet ,  James Carney ,  Janell Gottesman ,  Adrianus Donders ,  Michael Ujhelyi

发明人： John St. Ores ,  Sarah Audet ,  James Carney ,  Janell Gottesman ,  Adrianus Donders ,  Michael Ujhelyi

IPC分类号： G06Q40/00

CPC分类号： A61B5/0031 ,  G06F19/00 ,  G06Q40/08 ,  G16H10/20

摘要： A data collection system includes remote, implantable sensors for monitoring one or more patient parameters, collecting and processing data from those sensors and utilizing that data in the performance of a clinical study of a drug or other pharmacological agent. The system assists with preparation of a protocol for a clinical trial; presentation of that protocol; assuring compliance with the protocol; and generating useful results from data collected via the system and externally for presentation to an approval forum.

公开(公告)号：US20070276222A1

公开(公告)日：2007-11-29

申请号：US10599144

申请日：2005-03-21

申请人： Miha Fuderer ,  Franciscus Petrus Adrianus Donders

发明人： Miha Fuderer ,  Franciscus Petrus Adrianus Donders

IPC分类号： A61B5/055

CPC分类号： G01R33/34076 ,  G01R33/246

摘要： The invention relates to a system for magnetic resonance imaging (MRI). Such systems face an additional contribution to the inhomogeneity of the radio frequency (RF) field when high magnetic fields are applied. The invention tries to improve the homogeneity of the RF field for high field strengths, particularly for field strengths at or above 3 tesla. To improve the homogeneity an electrically conducting material (4) is positioned within the cavity (2) of the system. The material has a conductivity and a thickness which ensure that the total radial conductance in an xy-plane perpendicular to the symmetry axis of the cavity becomes isotropic.

摘要翻译： 本发明涉及一种用于磁共振成像（MRI）的系统。 当施加高磁场时，这样的系统对射频（RF）场的不均匀性有额外的贡献。 本发明试图提高高场强的RF场的均匀性，特别是对于3特斯拉以上的场强。 为了提高均匀性，导电材料（4）位于系统的空腔（2）内。 该材料具有导电性和厚度，其确保垂直于腔的对称轴的xy平面中的总径向电导变为各向同性。

公开(公告)号：US20070043400A1

公开(公告)日：2007-02-22

申请号：US11205415

申请日：2005-08-17

申请人： Adrianus Donders ,  Koen Weijand ,  Mark Knudson

发明人： Adrianus Donders ,  Koen Weijand ,  Mark Knudson

IPC分类号： A61N1/00

CPC分类号： A61N1/36146 ,  A61N1/36053 ,  A61N1/36085 ,  A61N1/36114

摘要： An apparatus for applying a signal to a nerve for the treatment of a disorder includes a first electrode and a second electrode. Each of the electrodes is adapted to be secured to a nerve of a patient. A signal generator is electrically connected to each of the first and second electrodes. The signal generator is adapted to create a signal having a first waveform at the first electrode and a second waveform at the second electrode. The waveforms have parameters selected to block propagation of neural action potentials. The waveforms have a repeating pattern of cycles of pulses with a delay period between at least selected ones of said pulses. In one embodiment, the first and second waveforms are out of phase for a cycle of one of the waveforms to occur during a delay period of the other of the waveforms.

摘要翻译： 用于向神经施加信号以用于治疗病症的装置包括第一电极和第二电极。 每个电极适于固定到患者的神经。 信号发生器电连接到第一和第二电极中的每一个。 信号发生器适于产生在第一电极处具有第一波形的信号和在第二电极处的第二波形。 波形具有选择的参数以阻止神经动作电位的传播。 这些波形具有脉冲周期的重复模式，其中延迟周期至少在所选择的脉冲之间。 在一个实施例中，在另一个波形的延迟周期期间，波形中的一个波形的周期是第一和第二波形异相。