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    DERMAL DELIVERY COMPOSITIONS AND METHODS
    8.
    发明申请
    DERMAL DELIVERY COMPOSITIONS AND METHODS 审中-公开
    DERMAL DELIVERY组合物和方法

    公开(公告)号：US20160250226A1

    公开(公告)日：2016-09-01

    申请号：US15151966

    申请日：2016-05-11

    申请人： Agile Therapeutics, Inc.

    发明人： Charles G. ARNOLD ,  Agis KYDONIEUS ,  Thomas M. ROSSI ,  Alfred F. ALTOMARI

    IPC分类号： A61K31/567 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32 ,  A61K9/00 ,  A61K9/70

    CPC分类号： A61K31/567 ,  A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/57 ,  A61K47/12 ,  A61K47/20 ,  A61K47/32

    摘要： A composition for transdermal delivery of a progestin for progestin hormone therapy is disclosed. Also disclosed is a transdermal delivery device comprising the composition. For progestin-only hormone therapy, the composition contains an anti-oxidant and does not contain an estrogen. For therapy involving a progestin and an estrogen, the composition contains the progestin, the estrogen and an additional anti-oxidant. Methods of improving the stability of progestin-containing compositions comprising oxidative agents are also disclosed. The methods comprise including one or more anti-oxidants in the compositions.

    摘要翻译： 公开了用于孕激素治疗孕激素透皮递送的组合物。 还公开了包含该组合物的透皮递送装置。 对于仅孕激素治疗，该组合物含有抗氧化剂并且不含有雌激素。 对于涉及孕激素和雌激素的治疗​​，组合物含有孕激素，雌激素和另外的抗氧化剂。 还公开了改善含有孕激素的组合物包含氧化剂的稳定性的方法。 所述方法包括在组合物中包含一种或多种抗氧化剂。

    DERMAL DELIVERY DEVICE WITH IN SITU SEAL
    9.
    发明申请
    DERMAL DELIVERY DEVICE WITH IN SITU SEAL 审中-公开
    带密封件的DERMAL DELIVERY设备

    公开(公告)号：US20140350493A1

    公开(公告)日：2014-11-27

    申请号：US14264427

    申请日：2014-04-29

    申请人： Agile Therapeutics, Inc.

    发明人： Agis KYDONIEUS ,  Robert G. CONWAY ,  Thomas M. ROSSI

    IPC分类号： A61K9/70 ,  A61K47/14 ,  A61K31/567 ,  A61K31/566 ,  A61K31/568 ,  A61K47/20 ,  A61K31/573

    CPC分类号： A61K9/7061 ,  A61F2013/00646 ,  A61K9/7084 ,  A61K31/566 ,  A61K31/567 ,  A61K31/568 ,  A61K31/573 ,  A61K47/14 ,  A61K47/20

    摘要： This invention relates to a transdermal drug delivery device that comprises an active ingredient (AI) layer, having a skin contacting surface and a non-skin contacting surface and comprising a volatile component, a release liner impermeable to the volatile component adjacent the skin contacting surface of the Al layer having a perimeter that extends beyond the perimeter of the Al layer in all directions, and an overlay comprising a pressure sensitive adhesive (PSA) that does not absorb the volatile component adjacent the non-skin contacting surface of the Al layer having a perimeter of which extends beyond the perimeter of the Al layer in all directions, wherein the release liner and the PSA of the overlay are in contact with and adhered to each other around the perimeter of the Al layer to form a seal that reduces or prevents volatile component loss.

    摘要翻译： 本发明涉及一种透皮药物递送装置，其包含活性成分（AI）层，其具有皮肤接触表面和非皮肤接触表面，并且包含挥发性成分，不透过皮肤接触表面的挥发性组分的剥离衬垫 的Al层具有在所有方向上延伸超出Al层的周边的周边，以及覆盖层，其包含不吸收与Al层的非皮肤接触表面相邻的挥发性组分的压敏粘合剂（PSA），所述粘合剂 其周边在所有方向上延伸超出Al层的周边，其中覆盖层的剥离衬垫和PSA与Al层的周边彼此接触并彼此粘附以形成密封，以减少或防止 挥发性成分损失。

    Transdermal hormone delivery system: compositions and methods
    10.
    发明授权
    Transdermal hormone delivery system: compositions and methods 有权
    透皮激素递送系统：组合物和方法

    公开(公告)号：US08883196B2

    公开(公告)日：2014-11-11

    申请号：US14080948

    申请日：2013-11-15

    申请人： Agile Therapeutics, Inc

    发明人： Te-Yen Chien

    IPC分类号： A61F13/02 ,  A61L15/16 ,  A61F13/00 ,  A61K9/70 ,  A61K9/00 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20

    CPC分类号： A61K9/7038 ,  A61K9/0014 ,  A61K9/7061 ,  A61K31/565 ,  A61K31/57 ,  A61K47/12 ,  A61K47/14 ,  A61K47/20 ,  A61K2300/00

    摘要： A transdermal hormone delivery system (THDS) is disclosed. The THDS is useful for control of fertility and as therapy for a variety of diseases and conditions treatable by robust delivery of progestin and estrogen hormones, particularly the progestin, levonorgestrel. The THDS comprises a backing layer, an adjoining adhesive polymer matrix comprising an effective amount of at least a progestin hormone, delivery of which is enhanced by one or more skin permeation enhancing agents present in pre-determined amounts. The THDS is capable of providing effective daily doses of progestin and estrogen hormones from a small surface area in contact with the skin, e.g., less than 20 square centimeters. Methods of fertility control and various types of hormone replacement therapy utilizing the THDS are also disclosed.

    摘要翻译： 公开透皮激素释放系统（THDS）。 THDS可用于控制生育力，并用于通过强力递送孕激素和雌激素激素，特别是孕激素左炔诺孕酮治疗的各种疾病和病症。 THDS包括背衬层，邻接的粘合剂聚合物基质，其包含有效量的至少一种孕激素，其输送通过以预定量存在的一种或多种皮肤渗透增强剂增强。 THDS能够从与皮肤接触的小表面积（例如小于20平方厘米）提供孕激素和雌激素的有效日剂量。 还公开了生育控制方法和利用THDS的各种类型的激素替代疗法。