公开(公告)号：US07238837B1

公开(公告)日：2007-07-03

申请号：US09147914

申请日：1997-10-02

申请人： Aharon Meir Eyal ,  Ponnampalam Elankovan

发明人： Aharon Meir Eyal ,  Ponnampalam Elankovan

IPC分类号： C07C59/08 ,  C07C51/42

CPC分类号： C07C51/47 ,  C07C51/48 ,  C07C59/08

摘要： The invention provides a process for the recovery of lactic acid from aqueous solutions containing at least one water-soluble lactate salt and having a pH of about between 4 and 14, comprising the steps of: contacting said aqueous solution with a cation exchanger which is at least partially in its acid form, said cation exchanger being water immiscible in both acid and salt form, whereby ion exchange is effected, protons are transferred from the cation exchanger to the aqueous solution to acidulate it and to form lactic acid therein and cations from the aqueous solution are bound by the cation exchanger; reacting the cations carrying cation exchanger to convert it into a cation exchanger which is at least partially in its acid form and to a second product, which second product is basic and comprises the cation of the salt; and recovering lactic acid from the lactic acid-containing acidulated aqueous solution by methods known per se.

摘要翻译： 本发明提供从含有至少一种水溶性乳酸盐的水溶液中回收乳酸并具有约4至14的pH的方法，包括以下步骤：使所述水溶液与阳离子交换剂接触，所述阳离子交换剂在 所述阳离子交换剂是酸和盐形式的水不混溶，由此进行离子交换，质子从阳离子交换剂转移到水溶液中以酸化并在其中形成阳离子 水溶液由阳离子交换剂结合; 使阳离子携带阳离子交换剂反应以将其转化为至少部分为其酸形式的阳离子交换剂和第二产物，该第二产物是碱性的并且包含盐的阳离子; 并通过本身已知的方法从含乳酸的酸化水溶液中回收乳酸。

公开(公告)号：US5859262A

公开(公告)日：1999-01-12

申请号：US980092

申请日：1997-11-26

申请人： Aharon Meir Eyal ,  Asher Vitner ,  Tal Reuveni ,  Betty Hazan

发明人： Aharon Meir Eyal ,  Asher Vitner ,  Tal Reuveni ,  Betty Hazan

IPC分类号： C12P17/04 ,  C07C51/42 ,  C07D305/12 ,  C12P7/58

CPC分类号： C12P17/04 ,  Y10S435/803

摘要： The invention provides a process for the recovery of erythorbic acid from an aqueous feed solution containing values of erythorbic acid at a concentration of less than 0.7 mol/kg, comprising adsorbing a major portion of said erythorbic acid with a solid phase adsorbent resin selected from resins carrying a pyridine function and resins of similar or weaker basicity; separating said erythorbic acid-containing resin from residual aqueous solution, and subjecting said erythorbic acid-containing resin to a desorbing operation with a neutral solvent at a temperature of at least 20.degree. C. higher than the temperature at which said adsorption is carried out, whereby there is obtained a solution of erythorbic acid in solvent in which the concentration of erythorbic acid is at least equal to its concentration in said aqueous feed solution.

摘要翻译： 本发明提供了从含有浓度小于0.7mol / kg的异抗坏血酸的含水进料溶液中回收异抗坏血酸的方法，其包括用选自树脂的固相吸附树脂吸附大部分所述异抗坏血酸 携带吡啶功能和碱性相似或较弱的树脂; 将所述含异抗坏血酸的树脂与残留的水溶液分离，并使所述含异抗坏血酸的树脂在比所述吸附进行的温度高至少20℃的温度下用中性溶剂进行解吸操作， 由此得到异氰酸在溶剂中的溶液，其中异抗坏血酸的浓度至少等于其在所述含水进料溶液中的浓度。

公开(公告)号：US20120227733A1

公开(公告)日：2012-09-13

申请号：US13320535

申请日：2011-10-24

申请人： Aharon Meir Eyal ,  Robert P. Jansen

发明人： Aharon Meir Eyal ,  Robert P. Jansen

IPC分类号： C13K13/00 ,  B01J19/00

CPC分类号： C13K1/02

摘要： A hydrolysis system comprising: (a) a reactor vessel including a sprinkler at an upper portion thereof and a drain; (b) a pump re-circulating a flow of an acidic reaction liquid from a selected height in said vessel to said sprinkler; (c) an acid supply mechanism delivering a supply of HCl at a concentration≧39% to a lower portion of said reactor vessel; and (d) a flow splitter diverting a portion of the acidic reaction liquid so that a level of liquid in the vessel remains in a predetermined range.

摘要翻译： 一种水解系统，包括：（a）在其上部包括喷洒器的反应器容器和排水管; （b）泵将酸性反应液体的流从所述容器中的选定高度重新循环到所述喷洒器; （c）向所述反应容器的下部输送浓度≥39％的HCl的酸供给机构; 和（d）分流器分流一部分酸性反应液体，使得容器中的液体水平保持在预定范围内。

公开(公告)号：US06667417B2

公开(公告)日：2003-12-23

申请号：US09367618

申请日：1999-11-19

申请人： Aharon Meir Eyal ,  David Witzke ,  Rod Fisher

发明人： Aharon Meir Eyal ,  David Witzke ,  Rod Fisher

IPC分类号： C07C5142

CPC分类号： C12P7/56 ,  C07C51/02 ,  C07C51/412 ,  C07C51/48 ,  C07C51/487 ,  C07C59/08

摘要： The invention provides a process for producing lactic acid from a medium containing an alkaline earth-metal salt of lactic acid, comprising (a) reacting a conjugated base of an alkali metal from a subsequent step with the medium to form a water soluble alkali metal lactate salt and a basic compound of the alkaline earth metal; (b) separating the water soluble alkali metal lactate salt and the basic compound of the alkaline earth-metal; (c) splitting the water soluble alkali metal lactate to form a conjugated alkali metal base and a lactic acid product, which product is selected from the group consisting of lactic acid; and (d) separating the conjugated alkali metal base and the lactic acid product; (e) reusing the separated conjugated alkali metal base or the product in the step (a); and (f) reusing the basic compound of the alkaline earth metal, separated in step (b) to form an alkaline earth metal salt of lactic acid.

摘要翻译： 本发明提供了一种由含有乳酸碱土金属盐的培养基生产乳酸的方法，包括（a）将来自后续步骤的碱金属的共轭碱与培养基反应，形成水溶性碱金属乳酸盐 盐和碱土金属的碱性化合物; （b）分离水溶性碱金属乳酸盐和碱土金属的碱性化合物; （c）分解水溶性碱金属乳酸盐以形成共轭碱金属碱和乳酸产物，该产物选自乳酸; 和（d）分离共轭碱金属碱和乳酸产物; （e）在步骤（a）中重新使用分离的共轭碱金属碱或产物; 和（f）重复使用在步骤（b）中分离的碱土金属的碱性化合物以形成乳酸的碱土金属盐。

公开(公告)号：US06274349B1

公开(公告)日：2001-08-14

申请号：US09319522

申请日：1999-08-23

申请人： Aharon Meir Eyal ,  Asher Vitner ,  Tal Reuveni

发明人： Aharon Meir Eyal ,  Asher Vitner ,  Tal Reuveni

IPC分类号： C12P1944

CPC分类号： C12P19/44

摘要： The invention provides a process for the preparation of long-chain alkyl glycosides, comprising reacting at least one substrate selected from a group consisting a carbohydrates and carbohydrates sources and at least one fatty alkanol of at least eight carbon atoms in a medium consisting of at least one glycosidase enzyme having a temperature optimum greater than 60° C. and having thermal stability half-life of greater than 24 hours at 80° C.

摘要翻译： 本发明提供了制备长链烷基糖苷的方法，包括使至少一种选自碳水化合物和碳水化合物源的底物与至少一种至少8个碳原子的脂肪链烷醇在至少包含至少8个碳原子的介质中反应 一种糖苷酶，其温度最适大于60℃，并且在80℃具有大于24小时的热稳定性半衰期。

公开(公告)号：US5976379A

公开(公告)日：1999-11-02

申请号：US43912

申请日：1998-06-02

申请人： Aharon Meir Eyal

发明人： Aharon Meir Eyal

IPC分类号： B01J39/00 ,  B01J39/04 ,  B01J47/00 ,  B01D15/04

CPC分类号： B01J47/00 ,  B01J39/00 ,  B01J39/043

摘要： Disclosed is a metathetic process of the type M'X+M"=M'Y+M"X, where M' dirs from M" and the reagents and the products are water-soluble salts, comprising the steps of (a) transferring a solution of M"Y through at least one column containing cation exchanger beads loaded with M' cations, obtained in step (b) hereinafter, whereby cation exchange takes place to form a solution of M'Y and cation exchanger beads loaded with M", and (b) transferring a solution of M'X through said column containing cation exchanger beads loaded with M" obtained in step (a) above.

摘要翻译： PCT No.PCT / GB96 / 02377。 371日期1998年6月2日 102（e）1998年6月2日PCT PCT 1996年9月26日PCT公布。 出版物WO97 / 13580 日期1997年4月17日公开是M'X + M“= M'Y + M'X型的复分解过程，其中M'与M”不同，试剂和产物是水溶性盐， 包括以下步骤：（a）通过至少一个含有阳离子交换剂珠的负载M'阳离子的载体转移M'Y的溶液，步骤（b）获得的阳离子交换剂珠在下文步骤（b）中获得，由此进行阳离子交换以形成M' Y和负载有M“的阳离子交换剂珠粒，和（b）通过载有上述步骤（a）中获得的M”的含有阳离子交换剂珠粒的M'X的溶液转移。

公开(公告)号：US20120264873A1

公开(公告)日：2012-10-18

申请号：US13378657

申请日：2011-06-26

申请人： Aharon Meir Eyal ,  Robert P. Jansen ,  Revital Mali ,  Asher Vitner

发明人： Aharon Meir Eyal ,  Robert P. Jansen ,  Revital Mali ,  Asher Vitner

IPC分类号： C13B50/00 ,  C12P7/02 ,  C12P7/40 ,  C12P13/04 ,  C12P7/06 ,  C12P7/16 ,  C12P7/64 ,  C12P7/04 ,  C12P7/14 ,  C12P21/00 ,  C08F10/02 ,  C08F10/06 ,  C08G63/08 ,  C08G63/02 ,  C08F20/12 ,  C09D133/08 ,  C13K13/00

CPC分类号： C12N1/22 ,  A23V2002/00 ,  C12P7/10 ,  C12P19/02 ,  C12P19/14 ,  C12P2203/00 ,  C13K1/02 ,  C13K7/00 ,  C13K13/00 ,  Y02E50/13 ,  Y02E50/16 ,  Y02E50/17 ,  A23V2250/60

摘要： A sugar mixture comprising: monosaccharides; oligosaccharides in a ratio ≧0.06 to total saccharides; disaccharides in a ratio to total saccharides ≧0.05; pentose in a ratio to total saccharides ≧0.05; at least one alpha-bonded di-glucose; and at least one beta-bonded di-glucose. Also disclosed are methods to make and/or use such mixtures.

摘要翻译： 一种糖混合物，其包含：单糖; 比例≥0.06的寡糖总糖; 二糖与总糖的比例≥0.05; 戊糖与总糖的比例≥0.05; 至少一种α-键合的二葡萄糖; 和至少一种β-键合的二葡萄糖。 还公开了制备和/或使用这种混合物的方法。

公开(公告)号：US07019170B2

公开(公告)日：2006-03-28

申请号：US09284160

申请日：1997-10-02

申请人： Aharon Meir Eyal ,  Patrick R. Gruber ,  Rod R. Fisher ,  Jeffrey J. Kolstad

发明人： Aharon Meir Eyal ,  Patrick R. Gruber ,  Rod R. Fisher ,  Jeffrey J. Kolstad

IPC分类号： C07C59/08 ,  C07C51/42

CPC分类号： C07C51/47 ,  C07C51/48 ,  C07C59/08

摘要： The invention provides a process for the recovery of lactic acid and products thereof from an aqueous solution containing free lactic acid and at least one lactate salt at a total concentration of at least 5%, the process comprising the steps of: extracting at least 70% of the free lactic acid from the aqueous solution by contacting the solution with a basic extractant, to form a lactic acid-containing extract and a lactic acid-depleted, lactate salt-containing aqueous solution; separating the lactic acid-containing extract from the depleted aqueous solution; and stripping the extracted lactic acid from the extract by methods known per se, to form a solution of lactic acid and a stripped extractant.

摘要翻译： 本发明提供了一种从含有游离乳酸和至少一种乳酸盐的水溶液中回收乳酸及其产物的方法，其总浓度至少为5％，该方法包括以下步骤：提取至少70％ 的游离乳酸通过使溶液与碱性提取剂接触而形成含乳酸的提取物和不含乳酸的乳酸盐盐水溶液; 从耗尽的水溶液中分离含乳酸的提取物; 并通过本身已知的方法从提取物中提取出的乳酸，以形成乳酸和剥离的萃取剂溶液。

公开(公告)号：US06172242B2

公开(公告)日：2001-01-09

申请号：US09296913

申请日：1999-04-22

申请人： Aharon Meir Eyal ,  Asher Vitner ,  Tal Reuveni ,  Betty Hazan

发明人： Aharon Meir Eyal ,  Asher Vitner ,  Tal Reuveni ,  Betty Hazan

IPC分类号： C07D30762

CPC分类号： C07D315/00

摘要： The invention provides a process for the recovery of erythorbic acid from an aqueous feed solution containing values of erythorbic acid at a concentration of less than 0.7 mol/kg, comprising extracting said erythorbic acid with a water-immiscible organic extractant composition comprising at least one secondary or tertiary alkyl amine in which the aggregate number of carbon atoms is at least 20, as a primary extractant, and a polar extraction enhancer compound; wherein said extractant composition comprises at least 2 moles of said polar extraction enhancer compound per one mole of primary extractant; separating said erythorbic acid-containing organic extractant composition from residual aqueous solution, and subjecting said erythorbic acid-containing organic extractant composition to a stripping operation with aqueous solution at a temperature of at least 20° C. higher than the temperature at which said extraction is carried out; whereby there is obtained an aqueous solution of erythorbic acid in which the concentration of erythorbic acid is higher than its concentration in said aqueous feed solution.

摘要翻译： 本发明提供了一种从含有浓度小于0.7mol / kg的异抗坏血酸的含水进料溶液中回收异抗坏血酸的方法，包括用与水不混溶的有机萃取剂组合物萃取所述异抗坏血酸，所述组合物包含至少一种二级 或其中总碳原子数为20以上的叔烷基胺作为主要萃取剂和极性提取增强剂化合物; 其中所述萃取剂组合物每1摩尔初级萃取剂包含至少2摩尔所述极性提取增强剂化合物; 将所述含异抗坏血酸的有机萃取剂组合物与残留水溶液分离，并将所述含异抗坏血酸的有机萃取剂组合物在至少20℃的温度下用水溶液进行剥离操作，所述温度高于所述提取物的温度 执行; 由此得到其中异抗坏血酸的浓度高于其在所述含水原料溶液中的浓度的异抗坏血酸水溶液。

公开(公告)号：US06171501B2

公开(公告)日：2001-01-09

申请号：US09214710

申请日：1999-03-10

申请人： Aharon Meir Eyal ,  Nadjda Cohen-Sydov

发明人： Aharon Meir Eyal ,  Nadjda Cohen-Sydov

IPC分类号： C07C22740

CPC分类号： C07C227/40

摘要： The invention provides a process for the separation of amino acids and their salts from impurities contained in an aqueous feed solution containing the same, the process comprising: a) bringing the feed solution into contact with a substantially immiscible extractant phase comprising an amine and an acid, both of which are substantially water immiscible in both free and salt forms, to extract amino acid and salts thereof in the phase, wherein the extraction is carried out while the feed solution is within two pH units of the initial pH of the feed solution; and b) backwashing the extractant phase with a substantially neutral aqueous system to recover substantially all of the extracted amino acid and the extracted salts thereof.

摘要翻译： 本发明提供了一种用于从含有该氨基酸及其盐的含水进料溶液中的杂质中分离氨基酸及其盐的方法，该方法包括：a）使进料溶液与包含胺和酸的基本上不混溶的萃取剂相接触 两者都是游离盐和盐形式基本上不混溶的水，以提取相中的氨基酸和其盐，其中进料溶液在进料溶液的初始pH的两个pH单位内进行; 和b）用基本上中性的水性体系反冲洗萃取相，以基本上回收所有提取的氨基酸及其提取的盐。