公开(公告)号：US08614077B2

公开(公告)日：2013-12-24

申请号：US13302775

申请日：2011-11-22

Applicant: William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins ,  Peter Meinhold ,  Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano

Inventor： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins ,  Peter Meinhold ,  Reid M. Renny Feldman ,  Uvini Gunawardena ,  Jun Urano

IPC: C12P7/16 ,  C12N9/10 ,  C12P17/10

CPC classification number: C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

Abstract translation: 本发明涉及从稀释的水溶液如发酵液中回收C3-C6醇的方法。 这样的方法提供了用于发酵的改进的体积生产率并允许酒精回收。 由于通过同时发酵和回收过程增加了醇产物的有效浓度，所以这种方法还允许在用过的发酵液的生产和干燥中减少能量消耗，这增加了每一批发酵液干燥产生和回收的醇的量。 因此，本发明允许以低资本生产和回收C3-C6醇，降低运行成本。

公开(公告)号：US08378160B2

公开(公告)日：2013-02-19

申请号：US13441459

申请日：2012-04-06

Applicant: Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

Inventor： Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

IPC: C10L1/04 ,  C07C2/04

CPC classification number: C10L1/08 ,  C07C1/24 ,  C07C2/08 ,  C07C2/76 ,  C07C5/03 ,  C07C9/14 ,  C07C9/15 ,  C07C51/265 ,  C10G3/00 ,  C10G50/00 ,  C10G69/126 ,  C10G2300/1011 ,  C10G2300/42 ,  C10G2400/02 ,  C10G2400/04 ,  C10G2400/08 ,  C10G2400/30 ,  C10L1/04 ,  C10L1/06 ,  C10L2200/043 ,  C10L2200/0469 ,  C10L2270/04 ,  C10L2290/26 ,  C10L2290/543 ,  C12P5/00 ,  C12P7/04 ,  C12P7/06 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/13 ,  Y02E50/17 ,  Y02P30/20 ,  Y02T50/678 ,  C07C11/02 ,  C07C15/00 ,  C07C63/26 ,  C07C11/09

Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.

公开(公告)号：US20120323055A1

公开(公告)日：2012-12-20

申请号：US13557066

申请日：2012-07-24

Applicant: Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

Inventor： Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor ,  David E. Henton

IPC: C10G3/00 ,  C12P7/02 ,  C10L1/04

CPC classification number: C10L1/08 ,  C07C1/24 ,  C07C2/08 ,  C07C2/76 ,  C07C5/03 ,  C07C9/14 ,  C07C9/15 ,  C07C51/265 ,  C10G3/00 ,  C10G50/00 ,  C10G69/126 ,  C10G2300/1011 ,  C10G2300/42 ,  C10G2400/02 ,  C10G2400/04 ,  C10G2400/08 ,  C10G2400/30 ,  C10L1/04 ,  C10L1/06 ,  C10L2200/043 ,  C10L2200/0469 ,  C10L2270/04 ,  C10L2290/26 ,  C10L2290/543 ,  C12P5/00 ,  C12P7/04 ,  C12P7/06 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/13 ,  Y02E50/17 ,  Y02P30/20 ,  Y02T50/678 ,  C07C11/02 ,  C07C15/00 ,  C07C63/26 ,  C07C11/09

Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.

Abstract translation: 本发明涉及来自生物质发酵的可再生组合物，以及制备这种组合物的综合方法。

公开(公告)号：US08283505B2

公开(公告)日：2012-10-09

申请号：US13344460

申请日：2012-01-05

Applicant: William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

Inventor： William A. Evanko ,  Aharon M. Eyal ,  David A. Glassner ,  Fudu Miao ,  Aristos A. Aristidou ,  Kent Evans ,  Patrick R. Gruber ,  Andrew C. Hawkins

IPC: C07C29/76

CPC classification number: C12M43/00 ,  C07C29/80 ,  C07C29/86 ,  C12C11/11 ,  C12M45/20 ,  C12P7/04 ,  C12P7/16 ,  Y02E50/10 ,  Y02E50/17 ,  Y10T29/49826 ,  C07C31/12

Abstract: This invention is directed to methods for recovery of C3-C6 alcohols from dilute aqueous solutions, such as fermentation broths. Such methods provide improved volumetric productivity for the fermentation and allows recovery of the alcohol. Such methods also allow for reduced energy use in the production and drying of spent fermentation broth due to increased effective concentration of the alcohol product by the simultaneous fermentation and recovery process which increases the quantity of alcohol produced and recovered per quantity of fermentation broth dried. Thus, the invention allows for production and recovery of C3-C6 alcohols at low capital and reduced operating costs.

公开(公告)号：US20090299109A1

公开(公告)日：2009-12-03

申请号：US12327723

申请日：2008-12-03

Applicant: Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor

Inventor： Patrick R. Gruber ,  Matthew W. Peters ,  Josefa M. Griffith ,  Yassin Al Obaidi ,  Leo E. Manzer ,  Joshua D. Taylor

IPC: C10L1/16 ,  C10G1/00 ,  C10L1/19 ,  C10L1/185 ,  C10L1/188

CPC classification number: C10L1/04 ,  C10G3/00 ,  C10G50/00 ,  C10G69/126 ,  C10G2300/1011 ,  C10G2400/08 ,  C10G2400/22 ,  C10G2400/30 ,  C10L1/06 ,  C10L1/08 ,  Y02E50/13 ,  Y02P30/20

Abstract: The present invention is directed to renewable compositions derived from fermentation of biomass, and integrated methods of preparing such compositions.

Abstract translation: 本发明涉及来自生物质发酵的可再生组合物，以及制备这种组合物的综合方法。

公开(公告)号：US07144977B2

公开(公告)日：2006-12-05

申请号：US10788696

申请日：2004-02-26

Applicant: Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Xiangsheng Meng

Inventor： Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad ,  Xiangsheng Meng

IPC: C08G63/08 ,  C07C59/08 ,  C07C51/42 ,  C12P7/56

CPC classification number: C07C51/48 ,  C07C67/08 ,  C12P7/56 ,  Y02P20/582 ,  C07C59/08 ,  C07C69/68

Abstract: The techniques for processing lactic acid/lactate salt mixtures are provided. Preferred mixtures for processing are obtained from fermentation broths, preferably from fermentation processes conducted at a pH of 4.8 or lower. The techniques generally concern the provision of separated lactic acid and lactate streams, from the mixtures. Preferred techniques of separation and processing of each of the streams are provided.

公开(公告)号：US07019170B2

公开(公告)日：2006-03-28

申请号：US09284160

申请日：1997-10-02

Applicant: Aharon Meir Eyal ,  Patrick R. Gruber ,  Rod R. Fisher ,  Jeffrey J. Kolstad

Inventor： Aharon Meir Eyal ,  Patrick R. Gruber ,  Rod R. Fisher ,  Jeffrey J. Kolstad

IPC: C07C59/08 ,  C07C51/42

CPC classification number: C07C51/47 ,  C07C51/48 ,  C07C59/08

Abstract: The invention provides a process for the recovery of lactic acid and products thereof from an aqueous solution containing free lactic acid and at least one lactate salt at a total concentration of at least 5%, the process comprising the steps of: extracting at least 70% of the free lactic acid from the aqueous solution by contacting the solution with a basic extractant, to form a lactic acid-containing extract and a lactic acid-depleted, lactate salt-containing aqueous solution; separating the lactic acid-containing extract from the depleted aqueous solution; and stripping the extracted lactic acid from the extract by methods known per se, to form a solution of lactic acid and a stripped extractant.

Abstract translation: 本发明提供了一种从含有游离乳酸和至少一种乳酸盐的水溶液中回收乳酸及其产物的方法，其总浓度至少为5％，该方法包括以下步骤：提取至少70％ 的游离乳酸通过使溶液与碱性提取剂接触而形成含乳酸的提取物和不含乳酸的乳酸盐盐水溶液; 从耗尽的水溶液中分离含乳酸的提取物; 并通过本身已知的方法从提取物中提取出的乳酸，以形成乳酸和剥离的萃取剂溶液。

公开(公告)号：US06534679B2

公开(公告)日：2003-03-18

申请号：US09927116

申请日：2001-08-10

Applicant: Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad

Inventor： Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad

IPC: C07C5908

CPC classification number: C07C51/48 ,  C07C67/08 ,  C12P7/56 ,  Y02P20/582 ,  C07C59/08 ,  C07C69/68

Abstract: The techniques for processing lactic acid/lactate salt mixtures are provided. Preferred mixtures for processing are obtained from fermentation broths, preferably from fermentation processes conducted at a pH of 4.8 or lower. The techniques generally concern the provision of separated lactic acid and lactate streams, from the mixtures. Preferred techniques of separation and processing of each of the streams are provided.

公开(公告)号：US06229046B1

公开(公告)日：2001-05-08

申请号：US08950289

申请日：1997-10-14

Applicant: Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad

Inventor： Aharon M. Eyal ,  John N. Starr ,  Rod Fisher ,  Betty Hazan ,  Riki Canari ,  David R. Witzke ,  Patrick R. Gruber ,  Jeffrey J. Kolstad

IPC: C07C5908

CPC classification number: C07C51/48 ,  C07C67/08 ,  C12P7/56 ,  Y02P20/582 ,  C07C59/08 ,  C07C69/68

Abstract: The techniques for processing lactic acid/lactate salt mixtures are provided. Preferred mixtures for processing are obtained from fermentation broths, preferably from fermentation processes conducted at a pH of 4.8 or lower. The techniques generally concern the provision of separated lactic acid and lactate streams, from the mixtures. Preferred techniques of separation and processing of each of the streams are provided.

Abstract translation: 提供乳酸/乳酸盐混合物的加工技术。 优选的用于加工的混合物从发酵液中获得，优选在pH4.8或更低的条件下进行发酵。 这些技术通常涉及从混合物中提供分离的乳酸和乳酸盐流。 提供了每种流的分离和处理的优选技术。

公开(公告)号：US06160173A

公开(公告)日：2000-12-12

申请号：US284108

申请日：1999-10-26

Applicant: Aharon Meir Eyal ,  Patrick R. Gruber ,  Paul McWilliams ,  David R. Witzke

Inventor： Aharon Meir Eyal ,  Patrick R. Gruber ,  Paul McWilliams ,  David R. Witzke

IPC: C07C51/47 ,  C07C51/48 ,  C07C67/08 ,  C07C51/487 ,  C07C51/493

CPC classification number: C07C51/48 ,  C07C51/47 ,  C07C67/08 ,  C07C59/08 ,  C07C69/68

Abstract: The invention provides a process for the recovery of purified lactic acid values from an aqueous feed solution containing lactic acid, lactic acid salt, or mixtures thereof, comprising: bringing the feed solution into contact with a substantially immiscible anion exchanger to form a substantially water-immiscible phase comprising an anion exchanger-lactic acid adduct; effecting a condensation reaction in the substantially water-immiscible phase between a carboxylic moiety of the lactic acid adduct and a moiety selected from a hydroxyl moiety and a primary or secondary amine moiety to respectively form a lactic acid ester or amine product; and separating the formed lactic acid product from the anion exchanger.

Abstract translation: PCT No.PCT / US97 / 17775 Sec。 371 1999年10月26日第 102（e）1999年10月26日PCT PCT 1997年10月2日PCT公布。 第WO98 / 15519号公报 日期：1998年04月16日本发明提供从含有乳酸，乳酸盐或其混合物的含水进料溶液中回收纯化乳酸值的方法，包括：使进料溶液与基本上不混溶的阴离子交换剂接触， 形成基本上与水不混溶的相，其包含阴离子交换 - 乳酸加合物; 在乳酸加合物的羧基部分和选自羟基部分和伯胺或仲胺部分的部分之间的基本上水不混溶的相中进行缩合反应，以分别形成乳酸酯或胺产物; 并将形成的乳酸产物与阴离子交换剂分离。