利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.011 秒)

    Erythromycin compounds
    2.
    发明授权
    Erythromycin compounds 失效
    红霉素化合物

    公开(公告)号：US5543400A

    公开(公告)日：1996-08-06

    申请号：US146695

    申请日：1993-11-01

    申请人： Constantin Agouridas ,  Alain Bonnefoy ,  Jean-Fran.cedilla.ois Chantot ,  Alexis Denis ,  Odile Le Martret

    发明人： Constantin Agouridas ,  Alain Bonnefoy ,  Jean-Fran.cedilla.ois Chantot ,  Alexis Denis ,  Odile Le Martret

    IPC分类号： A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/706 ,  A61P31/04 ,  C07H17/00 ,  C07H17/08

    CPC分类号： C07H17/08 ,  C07H17/00

    摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is ##STR2## m and n are individually integers from 0 to 6, A and B are individually a member selected from the group consisting of hydrogen, halogen and alkyl of 1 to 8 carbon atoms, the double bond geometry being E or Z or E+Z or A and B form a third bond between the carbon atoms to which they are attached, Ar is selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms optionally substituted with at least one member of the group consisting of free carboxy, alkoxycarbonyl, carboxy salified with a non-toxic, pharmaceutically acceptable base, amidified carboxy, --OH, halogen, --NO.sub.2, --CN, alkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio and alkynylthio of up to 12 carbon atoms, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms and cycloalkyl of 3 to 12 carbon atoms, all optionally substituted with at least one halogen and ##STR3## R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms, carbocyclic aryl, aryloxy, arylthio, heterocyclic aryl and aryloxy and arylthio containing at least one heteroatom, all optionally substituted as above and b) heterocyclic aryl having at least one heteroatom optionally substituted with at least one of the above substituents, Z is hydrogen or acyl of an organic carboxylic acid of 1 to 18 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic properties.

    摘要翻译： 选自下列化合物的化合物其中R为M的化合物，其中R为0至6的整数，A和B分别为选自氢，卤素 1至8个碳原子的烷基，双键几何为E或Z或E + Z或A和B在它们所连接的碳原子之间形成第三键，Ar选自a）碳环 任选被至少一个由游离羧基，烷氧基羰基，无毒的药学上可接受的碱盐化的羧基，酰胺化的羧基，-OH，卤素，-NO 2，-CN， 烷基，烯基，炔基，烷氧基，烯氧基，炔氧基，烷硫基，烯硫基和炔硫基，最多12个碳原子的N-烷基，N-烯基和N-炔基和3-12个碳原子的环烷基， 全部任选被至少一个卤素取代， nd R2各自独立地选自氢，1至12个碳原子的烷基，碳环芳基，芳氧基，芳硫基，杂环芳基和含有至少一个杂原子的芳氧基和芳硫基，全部如上所述被取代，和b）杂环芳基，其具有 至少一个任选被至少一个上述取代基取代的杂原子Z是氢或具有1至18个碳原子的有机羧酸的酰基及其无毒的药学上可接受的具有抗生素性质的酸加成盐。

    Erythromycin derivatives
    3.
    发明授权
    Erythromycin derivatives 失效
    红霉素衍生物

    公开(公告)号：US5527780A

    公开(公告)日：1996-06-18

    申请号：US146697

    申请日：1993-11-01

    申请人： Constantin Agouridas ,  Alain Bonnefoy ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    发明人： Constantin Agouridas ,  Alain Bonnefoy ,  Jean-Francois Chantot ,  Alexis Denis ,  Odile Le Martret

    IPC分类号： C07C211/27 ,  A61K31/70 ,  A61K31/7042 ,  A61K31/7048 ,  A61K31/7052 ,  A61P31/00 ,  A61P31/04 ,  C07C217/62 ,  C07D239/20 ,  C07D333/10 ,  C07H17/00 ,  C07H17/08

    CPC分类号： C07H17/08 ,  C07H17/00

    摘要： A compound selected from the group consisting of a compound of the formula ##STR1## wherein R is --(CH.sub.2).sub.n --Ar.sub.1 or --XAr.sub.2, n is an integer from 1 to 6, Ar.sub.1 and Ar.sub.2 are individually selected from the group consisting of a) carbocyclic aryl of up to 18 carbon atoms substituted by at least one member of the group consisting of free carboxy, alkoxy carbonyl and carboxyl salified with a pharmaceutically acceptable base, --OH, halogen, --NO.sub.2, --CN, ##STR2## and alkyl, cycloalkyl, alkenyl, alkynyl, alkoxy, alkenyloxy, alkynyloxy, alkylthio, alkenylthio, alkynylthio, N-alkyl, N-alkenyl and N-alkynyl of up to 12 carbon atoms optionally substituted with at least one halogen, R.sub.1 and R.sub.2 are individually hydrogen or alkyl of 1 to 12 carbon atoms, b) ##STR3## wherein R.sub.3 is selected from the group consisting of alkyl of 1 to 12 carbon atoms, optionally substituted carbocyclic aryl, aryloxy and arylthio, optionally substituted heterocyclic aryl, aryloxy and arylthio containing at least one heteroatom with the optional substituents being those of carbocyclic aryl above, X is an alkyl of 1 to 6 carbon atoms interrupted by a member of the group consisting of --O--, --S--, --SO--, --SO.sub.2, --CO--, ##STR4## Z is hydrogen or acyl of an organic carboxylic acid of up to 18 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having antibiotic activity against gram positive and gram negative bacteria.

    摘要翻译： 选自下式的化合物的化合物其中R为 - （CH 2）n -Ar 1或-XAr 2，n为1至6的整数，Ar 1和Ar 2分别选自 a）由至少一个由游离羧基，烷氧基羰基和与药学上可接受的碱成盐的羧基取代的至多18个碳原子的碳环芳基，-OH，卤素，-NO 2，-CN， 烷基，环烷基，烯基，炔基，烷氧基，烯氧基，炔氧基，烷硫基，烯硫基，炔硫基，任选被至少一个卤素取代的具有12个碳原子的N-烷基，N-烯基和N-炔基R1和R2 单独的氢或1至12个碳原子的烷基，b）其中R 3选自1至12个碳原子的烷基，任选取代的碳环芳基，芳氧基和芳硫基，任选取代的杂环芳基，芳氧基和芳硫基 含有至少一个杂原子 任选的取代基是上述碳环芳基的取代基，X是被-O - ， - S - ， - SO - ， - SO 2，-CO-， - CO-的成员间隔的1至6个碳原子的烷基， Z是具有至多18个碳原子的有机羧酸的氢或酰基，以及它们对革兰氏阳性和革兰氏阴性菌具有抗生素活性的无毒的药学上可接受的酸加成盐。

    Method of setting precious stones, as well as jewelry made by this method
    4.
    发明授权
    Method of setting precious stones, as well as jewelry made by this method 失效
    设置宝石的方法，以及通过这种方法制作的首饰

    公开(公告)号：US4821533A

    公开(公告)日：1989-04-18

    申请号：US144157

    申请日：1988-01-15

    申请人： Alain Bonnefoy

    发明人： Alain Bonnefoy

    IPC分类号： A44C17/04 ,  A44C27/00 ,  A44C5/00

    CPC分类号： A44C17/04 ,  Y10T29/23

    摘要： A method of setting precious stones in jewelry includes providing a metal support element of U-shaped cross section with two lateral bands separated by a central band and defining between them a channel, providing holes in the lateral bands and placing the stones into the channel and securing the stones in place in the channel with a wire passed through the holes from one band to the other across the channel.

    摘要翻译： 一种在首饰中设置宝石的方法包括提供具有由中心带分开的两个横向带的U形横截面的金属支撑元件，并在它们之间限定通道，在横向带中提供孔并将石头放置在通道中， 将石头固定在通道中的位置，其中穿过孔通过孔穿过通道。