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    3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and uses
    1.
    发明授权
    3,5-Diphenyl-1H-1,2,4-triazoles pharmaceutical compositions and uses 失效
    3,5-二苯基-1H-1,2,4-三唑类药物组合物及用途

    公开(公告)号：US4535090A

    公开(公告)日：1985-08-13

    申请号：US434451

    申请日：1982-10-15

    申请人： Giulio Galliani ,  Amedeo Omodei-Sale ,  Pietro Consonni ,  Alessandro Assandri

    发明人： Giulio Galliani ,  Amedeo Omodei-Sale ,  Pietro Consonni ,  Alessandro Assandri

    IPC分类号： A61K9/08 ,  A61K9/107 ,  A61K31/41 ,  A61P11/00 ,  C07C243/38 ,  C07D249/08 ,  C07D249/10 ,  C07D405/04 ,  C07D405/10

    CPC分类号： C07D249/08 ,  C07C243/38 ,  C07D405/04 ,  Y10S514/843

    摘要： 3,5-diphenyl-1H-1,2,4-triazoles with contragestational activity of the following formula ##STR1## wherein R may be located on one or the other of the two adjacent nitrogen atoms and may represent hydrogen or a group R.sub.5 CO-- wherein R.sub.5 is an aliphatic saturated or unsaturated hydrocarbyl containing from 1 to 20 carbon atoms, R.sub.1, R.sub.2 and R.sub.3, each independently are selected from hydrogen, lower alkyl and lower alkoxy or R.sub.2 and R.sub.3 together may represent a methylenedioxy group, and R.sub.4 is an aliphatic saturated or unsaturated hydrocarbyl group of from 1 to 20 carbons, with the proviso that when R is hydrogen or an R.sub.5 CO-- group wherein R.sub.5 contains 4 or less carbon atoms, R.sub.4 must contain 5 or more carbons.These compounds have proven to be highly effective in terminating pregnancy in several animal species after a single parenteral injection.

    摘要翻译： 具有下式的映射活性的3,5-二苯基-1H-1,2,4-三唑：其中R可以位于两个相邻氮原子的一个或另一个上，并且可以表示氢或基团R 5 CO- 其中R 5是含有1至20个碳原子的脂族饱和或不饱和烃基，R 1，R 2和R 3各自独立地选自氢，低级烷基和低级烷氧基，或者R 2和R 3一起可表示亚甲二氧基，并且R 4是 具有1至20个碳原子的脂肪族饱和或不饱和烃基，条件是当R是氢或R5含有4个或更少碳原子的R5CO-基时，R4必须含有5个或更多个碳。 已经证明这些化合物在单次肠胃外注射后在几种动物物种中终止妊娠是非常有效的。