公开(公告)号：US20060040965A1

公开(公告)日：2006-02-23

申请号：US11169313

申请日：2005-06-29

Applicant: Christopher Farthing ,  Paul Faulder ,  Alexander Frenkel ,  Martin Harrison ,  Xianyun Jiao ,  Frank Kayser ,  David Kopecky ,  Jinqian Liu ,  Sarah Lively ,  Rajiv Sharma ,  Stephen Shuttleworth

Inventor： Christopher Farthing ,  Paul Faulder ,  Alexander Frenkel ,  Martin Harrison ,  Xianyun Jiao ,  Frank Kayser ,  David Kopecky ,  Jinqian Liu ,  Sarah Lively ,  Rajiv Sharma ,  Stephen Shuttleworth

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: Compounds that modulate the action of ACK1 and LCK, and related compositions methods for treating ACK1- and LCK-mediated diseases are described. In one aspect, the compounds have the general structure: where the values of the substituents are provided herein.

Abstract translation: 描述了调节ACK1和LCK的作用的化合物以及用于治疗ACK1和LCK介导的疾病的相关组合物方法。 在一个方面，化合物具有一般结构：其中本文提供取代基的值。

公开(公告)号：US20070037803A1

公开(公告)日：2007-02-15

申请号：US11513614

申请日：2006-08-30

Applicant: Alexander Frenkel ,  Sarah Lively ,  Jay Powers ,  Andrew Smith ,  Daqing Sun ,  Craig Tomooka ,  Zhulun Wang

Inventor： Alexander Frenkel ,  Sarah Lively ,  Jay Powers ,  Andrew Smith ,  Daqing Sun ,  Craig Tomooka ,  Zhulun Wang

IPC: A61K31/5377 ,  A61K31/454 ,  A61K31/4184 ,  C07D413/02 ,  C07D403/02

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D235/30 ,  C07D401/06 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D471/04

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related conditions or disorders. In particular, the invention provides compounds which modulate the expression and/or function of proteins involved in inflammation, immune response regulation and cell proliferation. The subject compounds are 2-amino-imidazole derivatives.

Abstract translation: 提供了可用于治疗炎症和免疫相关病症或疾病的化合物，药物组合物和方法。 特别地，本发明提供调节参与炎症，免疫应答调节和细胞增殖的蛋白质的表达和/或功能的化合物。 主题化合物是2-氨基 - 咪唑衍生物。

公开(公告)号：US20060040961A1

公开(公告)日：2006-02-23

申请号：US11169312

申请日：2005-06-29

Applicant: John Buchanan ,  William Buckner ,  Simon Burkitt ,  Erin DiMauro ,  Christopher Farthing ,  Alexander Frenkel ,  Martin Harrison ,  Frank Kayser ,  Jinqian Liu ,  Sarah Lively ,  Teresa Marshall ,  David McGowan ,  Rajiv Sharma ,  Stephen Shuttleworth ,  Xiaotian Zhu

Inventor： John Buchanan ,  William Buckner ,  Simon Burkitt ,  Erin DiMauro ,  Christopher Farthing ,  Alexander Frenkel ,  Martin Harrison ,  Frank Kayser ,  Jinqian Liu ,  Sarah Lively ,  Teresa Marshall ,  David McGowan ,  Rajiv Sharma ,  Stephen Shuttleworth ,  Xiaotian Zhu

IPC: A61K31/519 ,  C07D491/02

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: The present invention relates to furanopyrimidine compounds having the general Formula I: and stereoisomers, tautomers, solvates, pharmaceutically acceptable salts and derivatives, and prodrugs thereof. The invention also includes pharmaceutical compositions comprising a compound of Formula I, methods of treating various diseases and conditions in a mammal, including inflammation, inhibition of T cell activation, proliferation, arthritis, organ transplant, ischemic or reperfusion injury, myocardial infarction, stroke, multiple sclerosis, inflammatory bowel disease, Crohn's disease, lupus, hypersensitivity, type 1 diabetes, psoriasis, dermatitis, Hashimoto's thyroiditis, Sjogren's syndrome, autoimmune hyperthyroidism, Addison's disease, autoimmune diseases, glomerulonephritis, allergic diseases, asthma, hayfever, eczema, cancer, colon carcinoma and thymoma, comprising administering to the mammal a therapeutically effective amount of a compound of Formula I. The invention also relates to methods of manufacturing medicaments, which comprise one or more compounds of Formula I.

Abstract translation: 本发明涉及具有通式I的呋喃并嘧啶化合物及其立体异构体，互变异构体，溶剂合物，药用盐和衍生物及其前药。 本发明还包括药物组合物，其包含式I化合物，治疗哺乳动物各种疾病和病症的方法，包括炎症，抑制T细胞活化，增殖，关节炎，器官移植，缺血或再灌注损伤，心肌梗塞，中风， 多发性硬化，炎性肠病，克罗恩病，狼疮，超敏反应，1型糖尿病，牛皮癣，皮炎，桥本氏甲状腺炎，干燥综合征，自身免疫性甲状腺功能亢进，艾迪生病，自身免疫性疾病，肾小球性肾炎，过敏性疾病，哮喘，干草病，湿疹， 结肠癌和胸腺瘤，包括向哺乳动物施用治疗有效量的式I化合物。本发明还涉及制备药物的方法，其包含一种或多种式I化合物。