公开(公告)号：US07141584B2

公开(公告)日：2006-11-28

申请号：US10731607

申请日：2003-12-09

申请人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

发明人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

IPC分类号： A61K31/454 ,  C07D401/12

CPC分类号： C07D401/10 ,  C07D233/50 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/10

摘要： This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

摘要翻译： 本发明涉及选自由式I表示的化合物组的IP受体拮抗剂：其中：R 1是由式（A），（B）或（C）表示的基团; 和说明书中定义的其它取代基及其药学上可接受的盐或晶体形式; 和含有它们的药物组合物; 以及用作治疗剂的方法。

公开(公告)号：US06472536B1

公开(公告)日：2002-10-29

申请号：US09666065

申请日：2000-09-19

申请人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

发明人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

IPC分类号： C07D23350

CPC分类号： C07D401/10 ,  C07D233/50 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/10

摘要： This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

摘要翻译： 本发明涉及选自由式I表示的化合物组的IP受体拮抗剂：其中：R1是由式（A），（B）或（C）表示的基团;以及本说明书中定义的其它取代基，它们 药学上可接受的盐或其晶体形式; 和含有它们的药物组合物; 以及用作治疗剂的方法。

公开(公告)号：US06184242B2

公开(公告)日：2001-02-06

申请号：US09137507

申请日：1998-08-20

申请人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

发明人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

IPC分类号： A61K314168

CPC分类号： C07D401/10 ,  C07D233/50 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/10

摘要： This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

摘要翻译： 本发明涉及选自由式I表示的化合物组的IP受体拮抗剂：其中：R1是由式（A），（B）或（C）表示的基团;以及本说明书中定义的其它取代基， 药学上可接受的盐或其晶体形式; 和含有它们的药物组合物; 以及用作治疗剂的方法。

公开(公告)号：US07312230B2

公开(公告)日：2007-12-25

申请号：US11240547

申请日：2005-09-30

申请人： Richard Leo Cournoyer ,  Paul Francis Keitz ,  Lee Edwin Lowrie, Jr. ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Dennis Mitsugu Yasuda

发明人： Richard Leo Cournoyer ,  Paul Francis Keitz ,  Lee Edwin Lowrie, Jr. ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Dennis Mitsugu Yasuda

IPC分类号： A61K31/44 ,  A61K31/435 ,  C07D215/38 ,  C07D215/00 ,  C07D215/02

CPC分类号： C07D263/56 ,  C07C271/22 ,  C07C311/08 ,  C07C311/21 ,  C07D209/08 ,  C07D215/14 ,  C07D235/18 ,  C07D307/12 ,  C07D307/80 ,  C07D405/14 ,  C07D409/04

摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.

摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中：R 1，R 2和R 3， 各自独立地为芳基或杂芳基; R 4是-COOH或四唑基; A，B，m，n和r如说明书中所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。

公开(公告)号：US06693098B2

公开(公告)日：2004-02-17

申请号：US09810436

申请日：2001-03-14

申请人： Richard Leo Cournoyer ,  Paul Francis Keitz ,  Lee Edwin Lowrie, Jr. ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Dennis Mitsugu Yasuda

发明人： Richard Leo Cournoyer ,  Paul Francis Keitz ,  Lee Edwin Lowrie, Jr. ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Dennis Mitsugu Yasuda

IPC分类号： A61K31495

CPC分类号： C07D263/56 ,  C07C271/22 ,  C07C311/08 ,  C07C311/21 ,  C07D209/08 ,  C07D215/14 ,  C07D235/18 ,  C07D307/12 ,  C07D307/80 ,  C07D405/14 ,  C07D409/04

摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.

摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中：R 1，R 2和R 3各自独立地在每个出现的芳基或杂芳基中; R 4， 是-COOH或四唑基; A，B，m，n和r如说明书中所定义;或各异构体，异构体的外消旋或非外消旋混合物或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。

公开(公告)号：US06596876B2

公开(公告)日：2003-07-22

申请号：US10159589

申请日：2002-05-31

申请人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

发明人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

IPC分类号： C07D23350

CPC分类号： C07D401/10 ,  C07D233/50 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/10

摘要： This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C);  and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods and their use as therapeutic agents.

摘要翻译： 本发明涉及选自由式I表示的化合物组的IP受体拮抗剂：其中：R1是由式（A），（B）或（C）表示的基团; 和说明书中定义的其它取代基及其药学上可接受的盐或晶体形式; 和含有它们的药物组合物; 方法及其作为治疗剂的用途。

公开(公告)号：US07056903B2

公开(公告)日：2006-06-06

申请号：US10434809

申请日：2003-05-09

申请人： Richard Leo Cournoyer ,  Paul Francis Keitz ,  Lee Edwin Lowrie, Jr. ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Dennis Mitsugu Yasuda

发明人： Richard Leo Cournoyer ,  Paul Francis Keitz ,  Lee Edwin Lowrie, Jr. ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Dennis Mitsugu Yasuda

IPC分类号： A61K31/60 ,  A01N37/36 ,  C07C315/00 ,  C07C229/00 ,  C07C205/00

CPC分类号： C07D263/56 ,  C07C271/22 ,  C07C311/08 ,  C07C311/21 ,  C07D209/08 ,  C07D215/14 ,  C07D235/18 ,  C07D307/12 ,  C07D307/80 ,  C07D405/14 ,  C07D409/04

摘要： This invention relates to compounds which are generally IP receptor antagonists and which are represented by Formula I: wherein: R1, R2, and R3 are each independently in each occurrence aryl or heteroaryl; R4 is —COOH or tetrazolyl; A, B, m, n, and r are as defined in the specification; or individual isomers, racemic or non-racemic mixtures of isomers, or pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds, methods for their use as therapeutic agents, and processes for their preparation.

摘要翻译： 本发明涉及通常为IP受体拮抗剂并由式I表示的化合物：其中：R 1，R 2和R 3， 各自独立地为芳基或杂芳基; R 4是-COOH或四唑基; A，B，m，n和r如说明书中所定义; 或各异构体，异构体的外消旋或非外消旋混合物，或其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物，其用作治疗剂的方法及其制备方法。

公开(公告)号：US06693200B2

公开(公告)日：2004-02-17

申请号：US10425778

申请日：2003-04-29

申请人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

发明人： Keith Roger Bley ,  Robin Douglas Clark ,  Alam Jahangir ,  Bruce Andrew Kowalczyk ,  Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Thomas Weitao Sun

IPC分类号： C07D23350

CPC分类号： C07D401/10 ,  C07D233/50 ,  C07D403/12 ,  C07D405/12 ,  C07D409/10 ,  C07D409/12 ,  C07D417/10

摘要： This invention relates to IP receptor antagonists selected from the group of compounds represented by Formula I: where: R1 is a group represented by formula (A), (B) or (C); and other substituents as defined in the specification, and their pharmaceutically acceptable salts or crystal forms thereof; and pharmaceutical compositions containing them; and methods for their use as therapeutic agents.

摘要翻译： 本发明涉及选自由式I表示的化合物组的IP受体拮抗剂：其中：R 1是由式（A），（B）或（C）表示的基团;以及其它如本说明书中定义的取代基 及其药学上可接受的盐或晶体形式; 和含有它们的药物组合物; 以及用作治疗剂的方法。

公开(公告)号：US06335459B1

公开(公告)日：2002-01-01

申请号：US09456167

申请日：1999-12-07

申请人： Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Daniel Lee Severance

发明人： Francisco Javier Lopez-Tapia ,  Alexander Victor Muehldorf ,  Counde O'Yang ,  Daniel Lee Severance

IPC分类号： C07C26100

CPC分类号： C07D257/04 ,  C07C271/28

摘要： This invention relates to compounds which are generally IP receptor modulators, particularly IP receptor agonists, and which are represented by Formula I: wherein R1, R2, R3, R4, R5, A, and B are as defined in the specification, and individual isomers, racemic or non-racemic mixtures of isomers, and pharmaceutically acceptable salts or solvates thereof. The invention further relates to pharmaceutical compositions containing such compounds and methods for their use as therapeutic agents.

摘要翻译： 本发明涉及通常为IP受体调节剂，特别是IP受体激动剂的化合物，其由式I表示：其中R1，R2，R3，R4，R5，A和B如本说明书中所定义，各异构体 异构体的外消旋或非外消旋混合物及其药学上可接受的盐或溶剂合物。 本发明还涉及含有这些化合物的药物组合物及其用作治疗剂的方法。