-
1.发明授权Methods for identifying and compounds useful for increasing the functional activity and cell surface expression of CF-associated mutant cystic fibrosis transmembrane conductance regulator 失效用于鉴定和用于增加CF相关突变型囊性纤维化跨膜传导调节物的功能活性和细胞表面表达的化合物的方法公开(公告)号：US08765376B2
公开(公告)日：2014-07-01
申请号：US13063333
申请日：2009-09-10
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
IPC分类号： A61K31/70 , A61K31/7088 , A61P1/16 , C12N15/11 , G01N33/68 , C07H21/02 , C12Q1/68 , C07H21/04
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致蛋白质细胞转运的调节，特别是CF相关突变型囊性纤维变性跨膜电导调节剂（CFTR）的调节。 此外，本发明涉及其用于治疗以ER相关蛋白错误折叠为特征的病症的组合物和方法，以及包括囊性纤维化（CF）在内的疾病相关蛋白的异常细胞运送。
-
2.发明申请METHODS FOR IDENTIFYING AND COMPOUNDS USEFUL FOR INCREASING THE FUNCTIONAL ACTIVITY AND CELL SURFACE EXPRESSION OF CF-ASSOCIATED MUTANT CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR 失效用于鉴定和化合物的方法用于增加CF相关突变体CYSTIC FIBROSIS TRANSMEMBRARE CONDUCTANCE REGULATOR的功能活性和细胞表面表达公开(公告)号：US20110245322A1
公开(公告)日：2011-10-06
申请号：US13063333
申请日：2009-09-10
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Tessari
IPC分类号： A61K31/713 , G01N33/68 , C40B30/04 , C07H21/02 , C07H21/00 , C07H21/04 , A61K31/7088 , A61P11/06 , A61P29/00 , A61P11/00 , A61P25/16 , A61P25/28 , A61P3/08 , A61P1/16 , A61P3/10
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致蛋白质细胞转运的调节，特别是CF相关突变型囊性纤维变性跨膜电导调节剂（CFTR）的调节。 此外，本发明涉及其用于治疗以ER相关蛋白错误折叠为特征的病症的组合物和方法，以及包括囊性纤维化（CF）在内的疾病相关蛋白的异常细胞运送。
-
3.发明申请Methods for Identifying and Compounds Useful for Increasing the Functional Activity and Cell Surface Expression of CF-Associated Mutant Cystic Fibrosis Transmembrance Conductance Regulator 审中-公开用于增加CF相关突变体囊性纤维化跨膜电导调节剂的功能活性和细胞表面表达的鉴定和化合物的方法公开(公告)号：US20140256790A1
公开(公告)日：2014-09-11
申请号：US14282090
申请日：2014-05-20
申请人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Angela Tessari
发明人： David Frederik Fischer , Richard Antonius Jozef Janssen , Marjet Roseboom , Amelia Katie Scaffidi , Michela Angela Tessari
IPC分类号： G01N33/50 , C12N15/113 , C12Q1/68 , G01N33/68
CPC分类号： G01N33/5041 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/531 , C12N2320/12 , C12N2330/31 , C12N2330/51 , C12Q1/6883 , G01N33/6872 , G01N33/6893 , G01N2500/00 , G01N2800/382
摘要： The present invention relates to agents, and methods for identifying compounds, which agents and compounds result in the modulation of cellular trafficking of proteins in particular that of CF-associated mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR). In addition, the invention relates to compositions and methods for the use thereof in treating conditions that are characterized by an ER-associated protein misfolding and abnormal cellular trafficking of disease-associated proteins, including cystic fibrosis (CF).
摘要翻译： 本发明涉及用于鉴定化合物的试剂和方法，所述试剂和化合物导致蛋白质细胞转运的调节，特别是CF相关突变型囊性纤维变性跨膜电导调节剂（CFTR）的调节。 此外，本发明涉及其用于治疗以ER相关蛋白错误折叠为特征的病症的组合物和方法，以及包括囊性纤维化（CF）在内的疾病相关蛋白的异常细胞运送。
-
-
搜索结果
3 条记录 (耗时 0.014 秒)
