公开(公告)号：US20120170044A1

公开(公告)日：2012-07-05

申请号：US12984328

申请日：2011-01-04

申请人： Amit Prabhakar ,  Soumyo Mukherji

发明人： Amit Prabhakar ,  Soumyo Mukherji

IPC分类号： G01N21/59 ,  G03F7/20 ,  G01N1/10

CPC分类号： G01N21/552 ,  G01N21/05 ,  G01N2021/0346

摘要： A microfabricated analysis chip with integrated waveguides for evanescent field absorption detection is provided. Fabrication of the microfluidic device may be performed by micropatterning a layer of photoresist or other suitable material using a single step photoresist process to produce a microchannel and an optical structure (e.g., a U-bend waveguide) in the microfluidic device. The microfluidic device couples a micro-channel network with a waveguide in a collinear fashion to maintain higher path length and incurring little or no scattering, dispersion, and divergence losses. A sample can be passed through the microchannel while light is transmitted through the waveguide. Any change in refractive index as well as change in optical absorbance property of fluid flowing in the microchannel can be detected by detecting changes in light output power (e.g., changes in absorbance). A change in concentration of solution in the microchannel can be determined by detecting a change in light absorbance output.

摘要翻译： 提供了一种具有集成波导用于ev逝场吸收检测的微制造分析芯片。 微流体装置的制造可以通过使用单步光致抗蚀剂工艺对一层光致抗蚀剂或其它合适的材料进行微图案化来实现，以在微流体装置中产生微通道和光学结构（例如，U形弯曲波导）。 微流体装置以共线方式将微通道网络与波导耦合以保持更高的路径长度并且产生很少或没有散射，色散和发散损失。 当光通过波导传输时，样品可以通过微通道。 可以通过检测光输出功率的变化（例如吸光度的变化）来检测折射率的任何变化以及在微通道中流动的流体的光吸收特性的变化。 可以通过检测吸光度输出的变化来确定微通道中溶液浓度的变化。

公开(公告)号：US08715558B2

公开(公告)日：2014-05-06

申请号：US13257948

申请日：2010-10-01

申请人： Amit Prabhakar ,  Soumyo Mukherji

发明人： Amit Prabhakar ,  Soumyo Mukherji

IPC分类号： B29C41/42

CPC分类号： G01N27/44791 ,  Y10T29/494 ,  Y10T137/8593

摘要： A seamless microchannel with aligned microelectrodes structure can be prepared to include a polymeric body defining a surface of a seamless microchannel. The microchannel is seamless in that it is formed by a single body of material having a conduit that is open at one surface and extends to another opening aligned with microelectrodes in another surface of the body. The rest of the microchannel is closed and defined by the single body of material. The seamless microchannel structure can be used in methods that include biosensors, coupling waveguides, capillary electrophoresis chips, microreactors, polymerase chain reaction-chips, and solving mathematical problems.

摘要翻译： 具有对准的微电极结构的无缝微通道可以被制备成包括限定无缝微通道表面的聚合体。 微通道是无缝的，因为它由具有导管的单体材料形成，该导管在一个表面处是开放的并且延伸到与主体另一表面中的微电极对准的另一个开口。 微通道的其余部分由单体材料封闭并限定。 无缝微通道结构可用于包括生物传感器，耦合波导，毛细管电泳芯片，微反应器，聚合酶链反应芯片以及解决数学问题的方法。

公开(公告)号：US08441645B2

公开(公告)日：2013-05-14

申请号：US12984328

申请日：2011-01-04

申请人： Amit Prabhakar ,  Soumyo Mukherji

发明人： Amit Prabhakar ,  Soumyo Mukherji

IPC分类号： G01N21/00

CPC分类号： G01N21/552 ,  G01N21/05 ,  G01N2021/0346

摘要： A microfabricated analysis chip with integrated waveguides for evanescent field absorption detection is provided. Fabrication of the microfluidic device may be performed by micropatterning a layer of photoresist or other suitable material using a single step photoresist process to produce a microchannel and an optical structure (e.g., a U-bend waveguide) in the microfluidic device. The microfluidic device couples a micro-channel network with a waveguide in a collinear fashion to maintain higher path length and incurring little or no scattering, dispersion, and divergence losses. A sample can be passed through the microchannel while light is transmitted through the waveguide. Any change in refractive index as well as change in optical absorbance property of fluid flowing in the microchannel can be detected by detecting changes in light output power (e.g., changes in absorbance). A change in concentration of solution in the microchannel can be determined by detecting a change in light absorbance output.

摘要翻译： 提供了一种具有集成波导用于ev逝场吸收检测的微制造分析芯片。 微流体装置的制造可以通过使用单步光致抗蚀剂工艺对一层光致抗蚀剂或其它合适的材料进行微图案化来实现，以在微流体装置中产生微通道和光学结构（例如，U形弯曲波导）。 微流体装置以共线方式将微通道网络与波导耦合以保持更高的路径长度并且产生很少或没有散射，色散和发散损失。 当光通过波导传输时，样品可以通过微通道。 可以通过检测光输出功率的变化（例如吸光度的变化）来检测折射率的任何变化以及在微通道中流动的流体的光吸收特性的变化。 可以通过检测吸光度输出的变化来确定微通道中溶液浓度的变化。

公开(公告)号：US20120193234A1

公开(公告)日：2012-08-02

申请号：US13257948

申请日：2010-10-01

申请人： Amit Prabhakar ,  Soumyo Mukherji

发明人： Amit Prabhakar ,  Soumyo Mukherji

IPC分类号： B01D57/02 ,  F03B13/00 ,  B29D22/00

CPC分类号： G01N27/44791 ,  Y10T29/494 ,  Y10T137/8593

摘要： A seamless microchannel with aligned microelectrodes structure can be prepared to include a polymeric body defining a surface of a seamless microchannel. The microchannel is seamless in that it is formed by a single body of material having a conduit that is open at one surface and extends to another opening aligned with microelectrodes in another surface of the body. The rest of the microchannel is closed and defined by the single body of material. The seamless microchannel structure can be used in methods that include biosensors, coupling waveguides, capillary electrophoresis chips, microreactors, polymerase chain reaction-chips, and solving mathematical problems.

摘要翻译： 具有对准的微电极结构的无缝微通道可以被制备成包括限定无缝微通道表面的聚合体。 微通道是无缝的，因为它由具有导管的单体材料形成，该导管在一个表面处是开放的并且延伸到与主体另一表面中的微电极对准的另一个开口。 微通道的其余部分由单体材料封闭并限定。 无缝微通道结构可用于包括生物传感器，耦合波导，毛细管电泳芯片，微反应器，聚合酶链反应芯片以及解决数学问题的方法。