公开(公告)号：US20070009606A1

公开(公告)日：2007-01-11

申请号：US11127298

申请日：2005-05-12

申请人： James Serdy ,  Emanuel Sachs ,  Thomas West ,  Sunil Saini ,  Jie Cai ,  Andrea Caruso ,  John Sharobiem ,  Peter Materna

发明人： James Serdy ,  Emanuel Sachs ,  Thomas West ,  Sunil Saini ,  Jie Cai ,  Andrea Caruso ,  John Sharobiem ,  Peter Materna

IPC分类号： A61K9/50

CPC分类号： A61L27/56 ,  A61F2/28 ,  A61F2002/30062 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30785 ,  A61F2002/30985 ,  A61F2210/0004 ,  A61F2230/0069 ,  A61F2310/00293 ,  A61F2310/00353 ,  A61L27/54 ,  A61L2300/412 ,  A61L2300/434 ,  A61L2300/602 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  Y10T428/15 ,  Y10T428/24273 ,  Y10T428/31504

摘要： The invention includes biostructures which may be characterized as having substantially all of the organic-solvent-soluble material in the form of a network of irregularly shaped perforated films. The biostructure may further include particles of a substantially-insoluble material, which may be a member of the calcium phosphate family. The biostructure may be osteoconductive. The biostructure may further contain an Active Pharmaceutical Ingredient or other bioactive substance. The API may be a substance which stimulates the production of bone morphogenetic protein, such as Lovastatin or related substances, thereby making the biostructure effectively osteoinductive. One or more of the polymers may have a resorption rate in the human body such as to control the release of the API. Methods of manufacture are also disclosed.

摘要翻译： 本发明包括生物结构，其可以被表征为具有基本上所有有机溶剂可溶性材料形式的不规则形状的穿孔膜的网络。 生物结构可以进一步包括可以是磷酸钙家族成员的基本不溶物质的颗粒。 生物结构可能是骨传导的。 生物结构还可含有活性药物成分或其他生物活性物质。 API可以是刺激骨形态发生蛋白（例如洛伐他汀或相关物质）生产的物质，从​​而使生物结构有效地成骨诱导。 一种或多种聚合物可能在人体内具有吸收速率，以便控制API的释放。 还公开了制造方法。

公开(公告)号：US20060018942A1

公开(公告)日：2006-01-26

申请号：US11139971

申请日：2005-05-31

申请人： Charles Rowe ,  Jie Cai ,  Andrea Caruso

发明人： Charles Rowe ,  Jie Cai ,  Andrea Caruso

IPC分类号： A61F13/00

CPC分类号： A61K9/0024 ,  A61K9/1647 ,  A61K9/1694 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/414 ,  A61L2300/434 ,  A61L2300/602 ,  A61L2300/622 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

摘要： The invention includes a method of three dimensional printing comprising manufacturing microbeads by an emulsion solvent extraction/evaporation process, followed by three dimensional printing onto powder layers comprising the microbeads. The invention also includes polymeric microbeads containing a bioactive substance or Active Pharmaceutical Ingredient, particularly a substance which stimulates the formation of bone, such as members of the statin family, or growth factors. The microbeads further may contain within themselves smaller particles such as particles of members of the calcium phosphate family, thereby being osteoconductive. The invention also includes aggregates of any of such microbeads together with any of various other types of suitably-sized particles, such as discrete particles of osteoconductive material or porogens. The invention also includes porous biostructures including macrochannels and having advantageous packing of osteoconductive particles.

摘要翻译： 本发明包括一种三维印刷方法，包括通过乳液溶剂萃取/蒸发方法制造微珠，随后在包含微珠的粉末层上进行三维印刷。 本发明还包括含有生物活性物质或活性药物成分的聚合物微珠，特别是刺激骨形成的物质，例如他汀类物质的成员或生长因子。 微珠还可以在其内部含有较小的颗粒，例如磷酸钙家族的成员颗粒，从而是骨传导的。 本发明还包括任何这种微珠的聚集体以及各种其它类型的适当尺寸的颗粒，例如骨传导性材料或致孔剂的离散颗粒。 本发明还包括多孔生物结构，包括宏通道并具有有利的包裹骨传导性颗粒。

公开(公告)号：US20050281856A1

公开(公告)日：2005-12-22

申请号：US11125336

申请日：2005-05-10

申请人： Jonathan McGlohorn ,  Sunil Saini ,  Andrea Caruso ,  Thomas West ,  Peter Materna ,  John Sharobiem ,  Thomas Bradbury

发明人： Jonathan McGlohorn ,  Sunil Saini ,  Andrea Caruso ,  Thomas West ,  Peter Materna ,  John Sharobiem ,  Thomas Bradbury

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61K31/724 ,  A61L27/36 ,  A61L27/42 ,  A61L27/56

CPC分类号： A61F2/28 ,  A61F2/30744 ,  A61F2/30767 ,  A61F2002/2835 ,  A61F2002/30059 ,  A61F2002/30062 ,  A61F2002/30153 ,  A61F2002/30154 ,  A61F2002/30179 ,  A61F2002/30224 ,  A61F2002/30225 ,  A61F2002/30235 ,  A61F2002/30261 ,  A61F2002/30263 ,  A61F2002/30271 ,  A61F2002/30604 ,  A61F2002/30677 ,  A61F2002/30772 ,  A61F2002/30785 ,  A61F2002/30795 ,  A61F2002/30807 ,  A61F2002/30813 ,  A61F2002/30815 ,  A61F2002/30822 ,  A61F2002/30957 ,  A61F2002/30985 ,  A61F2210/0004 ,  A61F2230/0019 ,  A61F2230/0021 ,  A61F2230/0058 ,  A61F2230/0069 ,  A61F2230/0082 ,  A61F2230/0084 ,  A61F2310/00293 ,  A61K31/724 ,  A61L27/3608 ,  A61L27/365 ,  A61L27/425 ,  A61L27/56

摘要： The present invention is directed to a biostructure comprising an osteoconductive member and an osteoinductive material. The osteoinductive material may be located within a cavity in the osteoconductive material. In one aspect of the invention the osteoinductive material is demineralized bone matrix and the osteoconductive member comprises tricalcium phosphate.

摘要翻译： 本发明涉及包括骨传导构件和骨诱导材料的生物结构。 骨诱导材料可以位于骨传导材料的腔内。 在本发明的一个方面，骨诱导材料是去矿物质骨基质，并且骨传导性构件包括磷酸三钙。