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1.发明授权Stem cells of the islets of langerhans and their use in treating diabetes mellitus 有权朗格汉斯胰岛的干细胞及其在治疗糖尿病中的应用公开(公告)号：US08110399B2
公开(公告)日：2012-02-07
申请号：US11438790
申请日：2006-05-22
申请人： Joel F. Habener , Henryk Zulewski , Melissa K. Thomas , Elizabeth J. Abraham , Mario Vallejo , Colin A. Leech , Anna Louise Nolan , Andreas Lechner
发明人： Joel F. Habener , Henryk Zulewski , Melissa K. Thomas , Elizabeth J. Abraham , Mario Vallejo , Colin A. Leech , Anna Louise Nolan , Andreas Lechner
CPC分类号： A01K67/0271 , A61K35/12 , A61K2035/122 , C12N5/0678 , C12N2500/34 , C12N2501/11 , C12N2501/115 , C12N2501/335 , C12N2510/02
摘要： Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin and ABCG2 have been identified as molecular markers for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin and/or ABCG2-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.
摘要翻译： 描述了用于治疗I型胰岛素依赖性糖尿病和其它条件的方法和组合物，其使用能够分化成多种胰岛细胞（包括产生胰岛素的β细胞）以及肝细胞的新鉴定的干细胞。 Nestin和ABCG2已被鉴定为胰干细胞的分子标记，而细胞角蛋白-19可作为不同类型的胰岛导管细胞的标记物。 描述了方法，其中可以从胰岛中分离巢蛋白和/或ABCG2-阳性干细胞并进行培养以获得进一步的干细胞或假胰岛样结构。 公开了胰腺干细胞离体分化方法。 描述了方法，其中胰腺干细胞可以被分离，扩增和移植到有需要的患者中，同种异体地，异质性或异质性的，以提供丢失或损伤的胰岛素分泌细胞或其他细胞的替代。
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公开(公告)号：US20100255136A1
公开(公告)日：2010-10-07
申请号：US12755602
申请日：2010-04-07
IPC分类号： B29C45/80
CPC分类号： B29C45/76 , B29C45/1761 , B29C45/5008 , B29C2045/1792 , B29C2045/5032 , B29C2045/5056 , B29C2945/76006 , B29C2945/76013 , B29C2945/76214 , B29C2945/76381 , B29C2945/76481
摘要： The invention relates to an injection unit (1) of an injection molding machine which is arranged movable relatively to a machine base (2) of the injection molding machine in an axial direction (A), wherein the injection unit (1) comprises a base body (3) at which a screw cylinder (4) is arranged, wherein a screw (5) is arranged rotatable and axially movable in the screw cylinder (4), wherein the screw (5) is connected with a drive element (6) at one of its axial ends which can rotate the screw and can also move it in axial direction (A) and wherein the drive element (6) comprises a gear element (7) which is movable in axial direction (A) as well as an actuator (8) which is in engagement with the gear element (7) and with the base body (3) and which can perform a translational movement in axial direction (A). To obtain an elementary design which guarantees a high precision the invention is characterized in that the base body (3) is designed as a one-piece block which has a plate-shaped reception (9) for the screw cylinder (4) at one of its axial ends and has a plate-shaped reception (10) for the actuator (8) at its opposite axial end.
摘要翻译： 本发明涉及一种注射成型机的注射单元（1），其可相对于注射成型机的机器基座（2）沿轴向方向（A）移动，其中注射单元（1）包括基座 主体（3），其上配置有螺杆（4），其中，螺杆（5）在所述螺杆（4）中可旋转地并且可轴向移动，其中所述螺钉（5）与驱动元件（6）连接， 在其轴向端部之一处，其可以旋转螺杆并且还可以在轴向方向（A）上移动，并且其中驱动元件（6）包括可在轴向方向（A）上移动的齿轮元件（7） 致动器（8），其与齿轮元件（7）和基体（3）接合并且可以在轴向方向（A）上进行平移运动。 为了获得保证高精度的基本设计，本发明的特征在于，基体（3）被设计为一体式块体，其具有用于螺杆缸（4）的板状接收（9） 其轴向端部并且在其相对的轴向端处具有用于致动器（8）的板状接收（10）。
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3.发明申请Stem cells of the islets of langerhans and their use in treating diabetes mellitus 有权朗格汉斯胰岛的干细胞及其在治疗糖尿病中的应用公开(公告)号：US20070128176A1
公开(公告)日：2007-06-07
申请号：US11438790
申请日：2006-05-22
申请人： Joel Habener , Henryk Zulewski , Melissa Thomas , Elizabeth Abraham , Mario Vallejo , Colin Leech , Anna Nolan , Andreas Lechner
发明人： Joel Habener , Henryk Zulewski , Melissa Thomas , Elizabeth Abraham , Mario Vallejo , Colin Leech , Anna Nolan , Andreas Lechner
CPC分类号： A01K67/0271 , A61K35/12 , A61K2035/122 , C12N5/0678 , C12N2500/34 , C12N2501/11 , C12N2501/115 , C12N2501/335 , C12N2510/02
摘要： Methods and compositions are described for the treatment of type I insulin-dependent diabetes mellitus and other conditions using newly identified stem cells that are capable of differentiation into a variety of pancreatic islet cells, including insulin-producing beta cells, as well as hepatocytes. Nestin and ABCG2 have been identified as molecular markers for pancreatic stem cells, while cytokeratin-19 serves as a marker for a distinct class of islet ductal cells. Methods are described whereby nestin and/or ABCG2-positive stem cells can be isolated from pancreatic islets and cultured to obtain further stem cells or pseudo-islet like structures. Methods for ex vivo differentiation of the pancreatic stem cells are disclosed. Methods are described whereby pancreatic stem cells can be isolated, expanded, and transplanted into a patient in need thereof, either allogeneically, isogeneically or xenogenically, to provide replacement for lost or damaged insulin-secreting cells or other cells.
摘要翻译： 描述了用于治疗I型胰岛素依赖性糖尿病和其它条件的方法和组合物，其使用能够分化成多种胰岛细胞（包括产生胰岛素的β细胞）以及肝细胞的新鉴定的干细胞。 Nestin和ABCG2已被鉴定为胰干细胞的分子标记，而细胞角蛋白-19可作为不同类型的胰岛导管细胞的标记物。 描述了方法，其中可以从胰岛中分离巢蛋白和/或ABCG2-阳性干细胞并进行培养以获得进一步的干细胞或假胰岛样结构。 公开了胰腺干细胞离体分化方法。 描述了方法，其中胰腺干细胞可以被分离，扩增和移植到有需要的患者中，同种异体地，异质性或异质性的，以提供丢失或损伤的胰岛素分泌细胞或其他细胞的替代。
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公开(公告)号：US08092206B2
公开(公告)日：2012-01-10
申请号：US12755602
申请日：2010-04-07
IPC分类号： B29C45/80
CPC分类号： B29C45/76 , B29C45/1761 , B29C45/5008 , B29C2045/1792 , B29C2045/5032 , B29C2045/5056 , B29C2945/76006 , B29C2945/76013 , B29C2945/76214 , B29C2945/76381 , B29C2945/76481
摘要： The invention relates to an injection unit (1) of an injection molding machine which is arranged movable relatively to a machine base (2) of the injection molding machine in an axial direction (A), wherein the injection unit (1) comprises a base body (3) at which a screw cylinder (4) is arranged, wherein a screw (5) is arranged rotatable and axially movable in the screw cylinder (4), wherein the screw (5) is connected with a drive element (6) at one of its axial ends which can rotate the screw and can also move it in axial direction (A) and wherein the drive element (6) comprises a gear element (7) which is movable in axial direction (A) as well as an actuator (8) which is in engagement with the gear element (7) and with the base body (3) and which can perform a translational movement in axial direction (A). To obtain an elementary design which guarantees a high precision the invention is characterized in that the base body (3) is designed as a one-piece block which has a plate-shaped reception (9) for the screw cylinder (4) at one of its axial ends and has a plate-shaped reception (10) for the actuator (8) at its opposite axial end.
摘要翻译： 本发明涉及一种注射成型机的注射单元（1），其可相对于注射成型机的机器基座（2）沿轴向方向（A）移动，其中注射单元（1）包括基座 主体（3），其上配置有螺杆（4），其中，螺杆（5）在所述螺杆（4）中可旋转地并且可轴向移动，其中所述螺钉（5）与驱动元件（6）连接， 在其轴向端部之一处，其可以旋转螺杆并且还可以在轴向方向（A）上移动，并且其中驱动元件（6）包括可在轴向方向（A）上移动的齿轮元件（7） 致动器（8），其与齿轮元件（7）和基体（3）接合并且可以在轴向方向（A）上进行平移运动。 为了获得保证高精度的基本设计，本发明的特征在于，基体（3）被设计为具有用于螺杆（4）的板状接收（9）的单件块， 其轴向端部并且在其相对的轴向端处具有用于致动器（8）的板状接收件（10）。
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