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14 条记录 (耗时 0.021 秒)

    Compositions for detecting cell death and methods of use thereof
    2.
    发明授权
    Compositions for detecting cell death and methods of use thereof 有权
    用于检测细胞死亡的组合物及其使用方法

    公开(公告)号：US08999661B2

    公开(公告)日：2015-04-07

    申请号：US12511478

    申请日：2009-07-29

    申请人： Andrew Kung ,  Pallab Banerjee

    发明人： Andrew Kung ,  Pallab Banerjee

    IPC分类号： C12Q1/32 ,  G01N33/50 ,  C07K14/00 ,  C12N9/04

    CPC分类号： C12Q1/32 ,  G01N33/5011 ,  G01N2510/00

    摘要： The invention provides compounds and methods of their use in the detection of apoptosis and necrosis both in vitro and in vivo. Also provided are compounds and methods of their use in selective delivery of agents to cells undergoing apoptosis or necrosis. The compounds and methods are based on conjugates formed with a dehydrogenase such as lactate dehydrogenase, alcohol dehydrogenase, aldehyde dehydrogenase, and malate dehydrogenase. The compounds and methods are useful in the diagnosis and treatment of conditions characterized by apoptosis, including cancer, cardiac disease, neurologic disease including stroke, and autoimmunity. The compounds and methods offer distinct advantages over corresponding compounds and methods based on Annexin V. Also provided are methods for screening for compounds that modulate, i.e., inhibit or promote, apoptosis.

    摘要翻译： 本发明提供了它们用于体外和体内检测凋亡和坏死的化合物和方法。 还提供了它们用于选择性递送药物至经历凋亡或坏死的细胞的化合物和方法。 化合物和方法基于与脱氢酶形成的缀合物，例如乳酸脱氢酶，醇脱氢酶，醛脱氢酶和苹果酸脱氢酶。 该化合物和方法可用于诊断和治疗特征为细胞凋亡的病症，包括癌症，心脏病，神经系统疾病，包括中风和自身免疫。 化合物和方法相对于基于膜联蛋白V的相应化合物和方法提供明显的优点。还提供了筛选调节，即抑制或促进凋亡的化合物的方法。

    Phosphospecific Chemokine Receptor Antibodies
    5.
    发明申请
    Phosphospecific Chemokine Receptor Antibodies 有权
    磷酸化趋化因子受体抗体

    公开(公告)号：US20090170130A1

    公开(公告)日：2009-07-02

    申请号：US11994048

    申请日：2006-06-30

    申请人： Joshua Rubin ,  Andrew Kung

    发明人： Joshua Rubin ,  Andrew Kung

    IPC分类号： G01N33/574 ,  C07K16/18 ,  G01N33/53 ,  G01N33/566

    CPC分类号： C07K14/7158 ,  A61K2039/505 ,  C07K16/2866

    摘要： The present invention provides chemokine receptor antibodies that selectively bind to an activated form of the receptor but not to a non activated form of the receptor. In particular, the current invention provides phospho specific chemokine receptor antibodies. The antibodies can be used in several diagnostic, screening and purification methods.

    摘要翻译： 本发明提供趋化因子受体抗体，其选择性地结合受体的活化形式，但不与受体的非活化形式结合。 特别地，本发明提供磷酸特异性趋化因子受体抗体。 抗体可用于多种诊断，筛选和纯化方法。

    High repetition rate visible optical parametric oscillator
    6.
    发明申请
    High repetition rate visible optical parametric oscillator 有权

    公开(公告)号：US20070147443A1

    公开(公告)日：2007-06-28

    申请号：US11318234

    申请日：2005-12-23

    申请人： Andrew Kung ,  Shining Zhu ,  Shih-Yu Tu ,  Zhida Gao

    发明人： Andrew Kung ,  Shining Zhu ,  Shih-Yu Tu ,  Zhida Gao

    IPC分类号： H01S3/10 ,  H01S3/091 ,  H01S3/08 ,  H01S3/092

    CPC分类号： G02F1/39 ,  G02F1/3558 ,  G02F2202/20 ,  G02F2203/05

    摘要： A tunable coherent light source includes a pump laser for generating a pump beam and an optical parametric oscillator including a crystal exhibiting an output curve for a pump beam of a defined wavelength, the output curve defining wavelengths of signal and idler outputs based on periodically poled grating periods of the crystal. The crystal has a plurality of segments associated with a plurality of grating periods of the output curve, each segment of the plurality of segments having a different crystal structure. At least one of the plurality of segments comprises a crystal structure combining at least two of the grating periods A heating device heats the crystal to an elevated operating temperature and is adjustable for adjusting the output wavelengths of each of the segments.

    Laser display radiation source and method
    10.
    发明申请
    Laser display radiation source and method 审中-公开
    激光显示辐射源及方法

    公开(公告)号：US20070236779A1

    公开(公告)日：2007-10-11

    申请号：US11407532

    申请日：2006-04-07

    申请人： Andrew Kung ,  Zhida Gao ,  Shih-Yu Tu ,  Shining Zhu

    发明人： Andrew Kung ,  Zhida Gao ,  Shih-Yu Tu ,  Shining Zhu

    IPC分类号： G02F2/02

    CPC分类号： G02F1/3532 ,  G02F1/3558 ,  H04N9/3129

    摘要： In general, in one aspect, the invention features a method that includes converting radiation at a first wavelength λi to radiation at a second wavelength λg and exposing an article to the radiation at λg to convert the radiation at λg to radiation at a third wavelength λr and radiation at a fourth wavelength λb. λr is red radiation, λg is green radiation, and λb is blue radiation and the article includes lithium tantalate.

    摘要翻译： 通常，在一个方面，本发明的特征在于一种方法，其包括将第一波长λλ的辐射转换成第二波长λλ的辐射，并将物品暴露于 将λλ的辐射转换成λ3的辐射到第三波长λλ的辐射，并且在第四波长λλ下辐射， b 。 λ是红色辐射，λλ是绿色辐射，λλ是蓝色辐射，并且制品包括钽酸锂。