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公开(公告)号：US20070258999A1
公开(公告)日：2007-11-08
申请号：US10555073
申请日：2004-04-28
申请人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
发明人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译： 本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列 相关疾病。
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公开(公告)号：US20050136421A1
公开(公告)日：2005-06-23
申请号：US10818279
申请日：2004-04-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human).
摘要翻译： 本发明特征在于ABC1核酸和多肽用于诊断和治疗异常胆固醇调节。 本发明还涉及用于鉴定用于调节动物（例如人）中的胆固醇水平的化合物的方法。
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公开(公告)号：US20070298420A1
公开(公告)日：2007-12-27
申请号：US11604911
申请日：2006-11-28
申请人： Alan Attie , Mark Cook , Mark Gray-Keller , Michael Hayden , Simon Pimstone , Angela Brooks-Wilson
发明人： Alan Attie , Mark Cook , Mark Gray-Keller , Michael Hayden , Simon Pimstone , Angela Brooks-Wilson
IPC分类号： C12Q1/68 , C12Q1/02 , G01N33/566
CPC分类号： C12Q1/6883 , A61K31/64 , A61K49/0008 , C12Q2600/136 , C12Q2600/158 , G01N33/5008 , G01N33/566 , G01N33/92 , G01N2500/00 , G01N2500/04 , G01N2800/044
摘要： Methods and compounds are disclosed for lowering serum LDL levels or serum cholesterol levels, or for reducing the transport of cholesterol from the gut to the blood or the lymph, based on the observation that a gene known as ABC1 is necessary in order for cholesterol to be transported from the intestinal lumen into the bloodstream. A mutant chicken phenotype, known as the WHAM chicken, characterized by low levels of serum LDL and reduced transport of cholesterol, facilitated the discovery of this function of the ABC1 gene. Techniques which act to inhibit ABC1 activity in the cells of the intestinal wall will result in lower serum cholesterol.
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公开(公告)号：US07897744B2
公开(公告)日：2011-03-01
申请号：US10555073
申请日：2004-04-28
申请人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Conrad Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
发明人： Frank Plummer , Heinz Feldmann , Steven Jones , Yan Li , Nathalie Bastien , Robert Conrad Brunham , Angela Brooks-Wilson , Robert Holt , Christopher Upton , Rachel Roper , Caroline Astell , Steven Jones
CPC分类号： C07K14/005 , A61K2039/53 , C12N7/00 , C12N2770/20021 , C12N2770/20022 , G01N2333/165
摘要： The invention provides, in part, the genomic sequence of a putative coronavirus, the SARS virus, and provides novel nucleic acid and amino acid sequences that may be used, for example, for the diagnosis, prophylaxis, or therapy of a variety of SARS virus related disorders.
摘要翻译： 本发明部分地提供推定的冠状病毒（SARS）病毒的基因组序列，并且提供可用于例如诊断，预防或治疗各种SARS病毒的新型核酸和氨基酸序列 相关疾病。
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公开(公告)号：US20050019765A1
公开(公告)日：2005-01-27
申请号：US10479879
申请日：2002-06-07
IPC分类号： G01N33/50 , A61K45/00 , A61P3/00 , A61P9/00 , A61P9/10 , A61P15/08 , A61P15/16 , A61P25/00 , A61P25/02 , A61P25/14 , A61P25/16 , A61P25/28 , C12Q1/02 , G01N33/15 , G01N33/68 , C12Q1/68 , A61K49/00
CPC分类号： G01N33/689 , G01N33/6893 , G01N33/6896 , G01N2500/00
摘要： The invention features methods for treating, preventing or modulating a neurological disease or disorder, or for modulating an anaesthetic or a fertility process by administering compounds that modulate ABCA1 expression or activity. The invention also features methods for identifying compounds useful for such methods.
摘要翻译： 本发明的特征在于通过施用调节ABCA1表达或活性的化合物来治疗，预防或调节神经疾病或病症或调节麻醉剂或生育过程的方法。 本发明还涉及鉴定可用于这些方法的化合物的方法。
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