公开(公告)号：US20130138202A1

公开(公告)日：2013-05-30

申请号：US13761391

申请日：2013-02-07

Applicant: Ram H. Paul ,  Richard A. Swift ,  Oliver Bach ,  Ralf Steiner ,  Angela R. Barnett ,  Keith R. Milner

Inventor： Ram H. Paul ,  Richard A. Swift ,  Oliver Bach ,  Ralf Steiner ,  Angela R. Barnett ,  Keith R. Milner

IPC: A61F2/82

CPC classification number: A61F2/82 ,  A61F2/07 ,  A61F2/848 ,  A61F2/915 ,  A61F2002/075 ,  A61F2002/8483 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2210/0076 ,  A61F2220/0016 ,  A61F2220/0075 ,  A61F2250/0023 ,  A61F2250/0036 ,  A61F2250/0037

Abstract: A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.

Abstract translation: 灌注装置和用于修复身体血管损伤部分的输送系统。 灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。 一个或多个串联的倒钩可以沿着中间部分周向设置。 倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。 移植物可以与管状体相关联。 移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。 移植物也可以在近端部分和远端部分沿管状体的外表面延伸。 可以沿着中间部分施加可重塑的覆盖物。 还提供用于灌注植入物的递送装置和递送灌注植入物的方法。

公开(公告)号：US20130302381A1

公开(公告)日：2013-11-14

申请号：US13799013

申请日：2013-03-13

Applicant: Angela R. Barnett ,  Aparna R. Sarasam

Inventor： Angela R. Barnett ,  Aparna R. Sarasam

IPC: A61L31/16

CPC classification number: A61L31/16 ,  A61F2/82 ,  A61K9/0024 ,  A61K31/337 ,  A61K31/436 ,  A61K47/02 ,  A61K47/183 ,  A61K47/26 ,  A61M25/1002 ,  A61M2025/1004 ,  A61M2025/105 ,  A61M2025/1086 ,  A61M2025/109

Abstract: A medical device includes an implantable structure and a coating layer including a water-insoluble therapeutic agent and one or more additives selected from xylitol, iodine or Ethylenediaminetetraacetic acid (EDTA), and physiologically-acceptable salts thereof. The one or more additives can be present in an amount effective to increase the rate of release of the water-insoluble therapeutic agent from the coating layer. The implantable medical device structure can be an expandable structure such as a balloon or stent. Also described are methods of making and using such implantable medical devices and coating layers.

Abstract translation: 医疗装置包括可植入结构和包含水不溶性治疗剂和一种或多种选自木糖醇，碘或乙二胺四乙酸（EDTA）的添加剂的涂层及其生理学上可接受的盐。 一种或多种添加剂可以以有效增加水不溶性治疗剂从涂层释放速率的量存在。 可植入医疗装置结构可以是可膨胀结构，例如球囊或支架。 还描述了制造和使用这种可植入医疗装置和涂层的方法。