Abstract:
The present invention provides 8-oxoadenine derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The 8-oxoadenine derivatives act as modulators of Toll-like Receptor (TLR) 7 and thus may be used in the treatment of asthma, hepatitis, allergic diseases, viral and bacterial infection as well as cancer.
Abstract:
In one embodiment, a method includes receiving on a first communication link at a local router all routing information at a certain level of detail for each router of multiple routers communicating in a first flooding domain. A measure of distance is determined from a particular router in the first flooding domain to the local router. It is determined whether the measure of distance exceeds a threshold. If the measure of distance exceeds the threshold, then summary routing information with less than the certain level of detail is determined for the particular router. Also, certain routing information is sent over a different second communication link at the local router. The certain routing information includes the summary information for the particular router, and all routing information at the certain level of detail for a subset of routers communicating in the first flooding domain, which subset excludes the particular router.
Abstract:
A system and method for avoiding loss of prime in a primed fuel system of a diesel engine (10) that propels a motor vehicle. With the engine running, a control system (14) shuts down the engine when a fuel level sender (20) indicates an incipient risk of the fuel system losing its prime due to insufficient fuel in the tank (16). In one embodiment, the engine cannot be re-started until more fuel is added to the tank. Another feature allows engine re-starting and limited running after a shut-down by first turning the ignition switch (48) to OFF.
Abstract:
Compounds of formula (1), pharmaceutically acceptable salts, solvates and in vivo hydrolysable esters thereof, have activity as pharmaceuticals, in particular as modulators of chemokine receptor (especially CXCR2) activity, and may be in the treatment (therapeutic or prophylactic) of conditions/diseases in human and non-human animals which are exacerbated or caused by excessive or unregulated production of chemokines.
Abstract:
An exhaust gas recirculating system for a turbocharged diesel engine utilizes an electrically driven compression pump to boost exhaust gas pressure before return to the engine induction system. Exhaust gas is drawn from the exhaust system or stack some distance removed and downstream from the outlet from the exhaust turbine, compressed to overcome the intake manifold boost pressure, and returned to the intake system along an extended pipe to cool the gas. The compressor is energized from the vehicle battery during periods of demand for peak pressure demand on the engine thereby recycling recaptured energy from the battery to boost engine output. Exhaust turbine performance during periods of peak loading is also improved.
Abstract:
A scraper blade has a tip of hard material and a base of resilient material. The base has at least one concave surface on the front side adjacent to the base and may have an additional concave surface on the back side adjacent to the tip. When the blade is urged against a conveyor belt for removing material, a substantial vertical force created by a significant obstruction on the belt will compress the scraper blade and will cause the blade to deform and move away from the belt until the obstruction has passed. A scraper blade system includes the scraper blade and an adjustment block for holding and adjusting the scraper blade against the conveyor belt.
Abstract:
A scraper blade has a tip of hard material and a base of resilient material. The base has at least one concave surface on the front side adjacent to the base and may have an additional concave surface on the back side adjacent to the tip. When the blade is urged against a conveyor belt for removing material, a substantial vertical force created by a significant obstruction on the belt will compress the scraper blade and will cause the blade to deform and move away from the belt until the obstruction has passed. A scraper blade system includes the scraper blade and an adjustment block for holding and adjusting the scraper blade against the conveyor belt.
Abstract:
A diesel particulate filter of a motor vehicle is cleaned of ash, typically using equipment already available in a service shop. The filter apparatus is disconnected from the exhaust system of a motor vehicle. The filter apparatus is reversed and reconnected to the motor vehicle's exhaust system in a configuration opposite to which the filter apparatus was originally connected. The engine is started and allowed to run at a high idle and no load engine speed to blow ash from the diesel particulate filter into the exit tubing. The ash is then collected in an ash collector.