公开(公告)号：US20050209245A1

公开(公告)日：2005-09-22

申请号：US11082510

申请日：2005-03-17

申请人： Anita Chan ,  Jianxin Ren ,  Archana Sharma

发明人： Anita Chan ,  Jianxin Ren ,  Archana Sharma

IPC分类号： C07D405/12 ,  A61K31/496 ,  C07D43/02

CPC分类号： C07D405/12

摘要： Processes for preparing N-aryl-piperazine derivatives of formula I particularly (R)-4-cyano-N-[2-[4-(2,3-dihydro-1,4-benzodioxan-5-yl)-1-piperazinyl-propyl]-N-(2-pyridinyl)-benzamide, are disclosed. Compositions comprising N-aryl-piperazine derivatives and low levels of common impurities are also disclosed. In addition, products produced by the process are disclosed.

摘要翻译： 制备式I的N-芳基 - 哌嗪衍生物的方法，特别是（R）-4-氰基-N- [2- [4-（2,3-二氢-1,4-苯并二恶烷-5-基）-1-哌嗪基 丙基] -N-（2-吡啶基） - 苯甲酰胺。 还公开了包含N-芳基 - 哌嗪衍生物和低水平常见杂质的组合物。 此外，公开了通过该方法生产的产品。

公开(公告)号：US20080058521A1

公开(公告)日：2008-03-06

申请号：US11698258

申请日：2007-01-25

申请人： Lalitha Krishnan ,  David Blum ,  Anja Dilley ,  Sherry Pan ,  John Potoski ,  Uresh Shah ,  Archana Sharma ,  Henry Strong ,  Yanzhong Wu ,  Mei-Yi Zhang ,  Cynthia Blum

发明人： Lalitha Krishnan ,  David Blum ,  Anja Dilley ,  Sherry Pan ,  John Potoski ,  Uresh Shah ,  Archana Sharma ,  Henry Strong ,  Yanzhong Wu ,  Mei-Yi Zhang ,  Cynthia Blum

IPC分类号： C07D239/02 ,  C07D213/02 ,  C07D241/02 ,  C07D333/52

CPC分类号： C07D409/12 ,  C07D213/61 ,  C07D333/70

摘要： The present invention provides improved synthetic methods for the preparation of compounds that modulate proliferation or differentiation in a cell or tissue.

摘要翻译： 本发明提供了改进的调节细胞或组织中增殖或分化的化合物的合成方法。

公开(公告)号：US06241981B1

公开(公告)日：2001-06-05

申请号：US09242628

申请日：1999-02-19

申请人： Mark A. Cobb ,  Stephen F. Badylak ,  Gary Isom ,  Archana Sharma

发明人： Mark A. Cobb ,  Stephen F. Badylak ,  Gary Isom ,  Archana Sharma

IPC分类号： A01N6300

CPC分类号： A61K35/38 ,  A61K35/12 ,  A61K38/1825 ,  A61K38/185 ,  C12N5/0679 ,  C12N2501/115 ,  C12N2501/13 ,  A61K2300/00

摘要： The present invention relates to tissue graft constructs useful in promoting regrowth and healing of damaged or diseased nuerological related tissue structures. More particularly this invention is directed to a submucosa tissue graft construct and a method of inducing the formation of endogenous neurological structures at a site in need of endogenous neurological related tissue growth.

摘要翻译： 本发明涉及可用于促进受损或患病的相关组织结构的再生长和愈合的组织移植物构建体。 更具体地，本发明涉及粘膜下组织移植物构建体和在需要内源性神经系统相关组织生长的部位诱导内源性神经结构形成的方法。

公开(公告)号：US10406152B2

公开(公告)日：2019-09-10

申请号：US15507453

申请日：2016-03-09

申请人： Rhodes Technologies ,  C. Frederick M. Huntley ,  Erik Wayne Kataisto ,  Helge Alfred Reisch ,  Archana Sharma

发明人： C. Frederick M. Huntley ,  Erik Wayne Kataisto ,  Helge Alfred Reisch ,  Archana Sharma

IPC分类号： A61K31/485 ,  C07D489/12 ,  A61P25/04

摘要： The present disclosure provides acetate salts of buprenorphine, and its anhydrates, solvates, hydrates, and crystalline forms thereof, where the acetate salts of buprenorphine are essentially free of impurities. The disclosure further provides method of preparing the acetate salts, buprenorphine free base prepared from the acetate salts, other salts prepared from the free base, and pharmaceutical compositions thereof essentially free of impurities.

公开(公告)号：US20080319204A1

公开(公告)日：2008-12-25

申请号：US12120959

申请日：2008-05-15

申请人： Yanzhong Wu ,  Karen Sutherland ,  John Leo Considine ,  Bogdan Kazimierz Wilk ,  Pierre Giguere ,  Michael MacEwan ,  Archana Sharma ,  Alexander Gontcharov

发明人： Yanzhong Wu ,  Karen Sutherland ,  John Leo Considine ,  Bogdan Kazimierz Wilk ,  Pierre Giguere ,  Michael MacEwan ,  Archana Sharma ,  Alexander Gontcharov

IPC分类号： C07D209/96

CPC分类号： C07D209/96 ,  C07D403/04

摘要： Processes for preparing substituted oxindole-2-ones, and specifically the following, are described, wherein R1-R4, R6, and n are defined herein. The processes include reacting a first alkali metal hydroxide, a tetraalkyl ammonium salt, a benzonitrile, and R6X or XCH2(CH2)nX′, wherein R6 is C1 to C6 alkyl, substituted C1 to C6 alkyl, C3 to C8 cycloalkyl, substituted C3 to C8 cycloalkyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, heterocyclic, or substituted heterocyclic, X and X′ are, independently, leaving groups, and n is 1 to 5; (ii) reacting the product of step (i) with a second alkali metal hydroxide at a temperature of at least about 60° C.; (iii) reacting the product of step (ii) with an alkali alkoxide at a temperature of at least about 140° C. to form an oxindol-2-one; (iv) brominating the oxindol-2-one; and (v) coupling the brominated oxindol-2-one with a coupling reagent.

摘要翻译： 描述了制备取代羟吲哚-2-酮的方法，具体如下，其中R1-R4，R6和n如本文所定义。 所述方法包括使第一碱金属氢氧化物，四烷基铵盐，苄腈和R6X或XCH2（CH2）nX'反应，其中R6为C1至C6烷基，取代的C1至C6烷基，C3至C8环烷基，取代C3至 C8环烷基，芳基，取代的芳基，杂芳基，取代的杂芳基，杂环或取代的杂环，X和X'独立地为离去基团，n为1至5; （ii）使步骤（i）的产物与至少约60℃的温度下的第二碱金属氢氧化物反应; （iii）使步骤（ii）的产物与碱金属醇盐在至少约140℃的温度下反应，形成羟吲哚-2-酮; （iv）溴化羟吲哚-2-酮; 和（v）将溴代羟吲哚-2-酮与偶联剂偶联。