Costimulatory Molecules and Uses Thereof
    1.
    发明申请
    Costimulatory Molecules and Uses Thereof 审中-公开
    共刺激分子及其用途

    公开(公告)号:US20080317766A1

    公开(公告)日:2008-12-25

    申请号:US12128658

    申请日:2008-05-29

    CPC分类号: C07K14/4703 C07K16/18

    摘要: The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.

    摘要翻译: 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外,本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。

    Costimulatory Molecules and Uses thereof
    4.
    发明申请
    Costimulatory Molecules and Uses thereof 审中-公开
    共刺激分子及其用途

    公开(公告)号:US20080058257A1

    公开(公告)日:2008-03-06

    申请号:US11741133

    申请日:2007-04-27

    IPC分类号: A61K38/16 A61P43/00 C07K14/00

    CPC分类号: C07K14/4703 C07K16/18

    摘要: The invention relates to a novel costimulatory pathway mediated by a member of the semaphorin protein family, Sema4A, which is selectively expressed on the surface of dendritic cells. In addition, the invention relates to the use of Sema4A protein and protein derivatives in a method for the identification of immunomodulatory substances and to therapeutic applications making use thereof.

    摘要翻译: 本发明涉及由树突状细胞表面选择性表达的信号素蛋白家族成员Sema4A介导的新型共刺激途径。 此外,本发明涉及Sema4A蛋白质和蛋白质衍生物在鉴定免疫调节物质的方法中的用途以及利用其的治疗应用。