公开(公告)号：US20120058984A1

公开(公告)日：2012-03-08

申请号：US13257098

申请日：2010-03-15

申请人： Catherine Mary Alder ,  Ian Robert Baldwin ,  Nicholas Paul Barton ,  Amanda Jennifer Campbell ,  Aurelie Cecile Champigny ,  John David Harling ,  Aoife Caitriona Maxwell ,  Juliet Kay Simpson ,  Ian Edward David Smith ,  Christopher John Tame ,  Caroline Wilson ,  James Michael Woolven

发明人： Catherine Mary Alder ,  Ian Robert Baldwin ,  Nicholas Paul Barton ,  Amanda Jennifer Campbell ,  Aurelie Cecile Champigny ,  John David Harling ,  Aoife Caitriona Maxwell ,  Juliet Kay Simpson ,  Ian Edward David Smith ,  Christopher John Tame ,  Caroline Wilson ,  James Michael Woolven

IPC分类号： A61K31/506 ,  C07D417/14 ,  A61K31/5377 ,  A61K31/541 ,  A61P11/00 ,  A61P37/08 ,  A61P37/00 ,  A61P37/06 ,  A61P29/00 ,  A61P31/18 ,  A61P7/06 ,  A61P25/00 ,  A61P11/06 ,  A61P11/08 ,  A61P17/00 ,  A61P17/06 ,  A61P3/10 ,  A61P5/16 ,  A61P27/02 ,  A61P1/00 ,  C07D417/12

CPC分类号： C07D513/04 ,  C07D417/12 ,  C07D417/14

摘要： The invention is directed to certain novel compounds. Specifically, the invention is directed to compounds of formula (I): and salts thereof. The compounds of the invention are inhibitors of kinase activity, in particular Itk activity.

摘要翻译： 本发明涉及某些新化合物。 具体地，本发明涉及式（I）的化合物及其盐。 本发明的化合物是激酶活性的抑制剂，特别是Itk活性。

公开(公告)号：US08247377B2

公开(公告)日：2012-08-21

申请号：US12303791

申请日：2007-06-11

申请人： Heather Anne Barnett ,  Ian Baxter Campbell ,  Diane Mary Coe ,  Anthony William James Cooper ,  Graham George Adam Inglis ,  Haydn Terence Jones ,  Steven Philip Keeling ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone ,  Gordon Gad Weingarten ,  James Michael Woolven

发明人： Heather Anne Barnett ,  Ian Baxter Campbell ,  Diane Mary Coe ,  Anthony William James Cooper ,  Graham George Adam Inglis ,  Haydn Terence Jones ,  Steven Philip Keeling ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone ,  Gordon Gad Weingarten ,  James Michael Woolven

IPC分类号： A61K31/44 ,  A61K31/40 ,  A61P23/00

CPC分类号： C07D231/38

摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.

摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是 治疗炎症，过敏和/或自身免疫病症。

公开(公告)号：US20120277279A1

公开(公告)日：2012-11-01

申请号：US13548573

申请日：2012-07-13

申请人： Heather Anne BARNETT ,  Ian Baxter Campbell ,  Diane Mary Coe ,  Anthony William James Cooper ,  Graham George Adam Inglis ,  Haydn Terence Jones ,  Steven Philip Keeling ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone ,  Gordon Gad Weingarten ,  James Michael Woolven

发明人： Heather Anne BARNETT ,  Ian Baxter Campbell ,  Diane Mary Coe ,  Anthony William James Cooper ,  Graham George Adam Inglis ,  Haydn Terence Jones ,  Steven Philip Keeling ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone ,  Gordon Gad Weingarten ,  James Michael Woolven

IPC分类号： A61K31/415 ,  A61P37/08 ,  A61P11/10 ,  A61P25/00 ,  A61P29/00 ,  A61P17/00 ,  A61P25/28 ,  A61P35/00 ,  A61P31/06 ,  A61P37/06 ,  A61P17/06 ,  A61P17/04 ,  A61P11/06 ,  A61P19/04

CPC分类号： C07D231/38

摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.

摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是 治疗炎症，过敏和/或自身免疫状况。

公开(公告)号：US20100234441A1

公开(公告)日：2010-09-16

申请号：US12303791

申请日：2007-06-11

申请人： Heather Anne Barnett ,  Ian Baxter Campbell ,  Diane Mary Coe ,  Anthony William James Cooper ,  Graham George Adam Inglis ,  Haydn Terence Jones ,  Steven Philip Keeling ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone ,  Gordon Gad Weingarten ,  James Michael Woolven

发明人： Heather Anne Barnett ,  Ian Baxter Campbell ,  Diane Mary Coe ,  Anthony William James Cooper ,  Graham George Adam Inglis ,  Haydn Terence Jones ,  Steven Philip Keeling ,  Simon John Fawcett MacDonald ,  Iain McFarlane McLay ,  Philip Alan Skone ,  Gordon Gad Weingarten ,  James Michael Woolven

IPC分类号： A61K31/415 ,  C07D231/38 ,  A61P19/02 ,  A61P17/00 ,  A61P29/00 ,  A61P25/00

CPC分类号： C07D231/38

摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.

摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是 治疗炎症，过敏和/或自身免疫病症。